Results 101 to 110 of about 855,886 (285)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Norma policéntrica del español frente a la traducción jurídica polaco‑española
Między Oryginałem a Przekładem, 2016 Polycentric Spanish Norm Towards the Polish‑Spanish Legal Translation The Spanish, being the official language of Spain and many other countries, is characterized by an important dialectal diversity that is reflected in the differences at all ...
Piotr Sorbet
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Residential Mobility Decreases Neural Responses to Social Norm Violation
Frontiers in Psychology, 2019 Social norms are essential, but they vary across cultures and societies. With the internationalization of human society, population mobility has greatly increased, especially in developing countries, which can have an impact on people’s psychological ...
Siyang Luo +6 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
MathematicsWe introduce the space of holomorphic growth spaces with values in a Banach lattice. We provide norm and essential norm estimates of the embedding operator, and we completely characterize the bounded and compact embeddings of the growth spaces using ...
Nihat Gökhan Göğüş
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THE STUDY OF BIOLOGICAL VALUE OF QUINOA SEEDS (CHENOPODIUM QUINOA WILLD.) TO CREATE SPECIALIZED FOOD PRODUCTS [PDF]
Техника и технология пищевых производств, 2016 Nowadays, an important part of the world food problem is a shortage of protein in the diet. This is a complicated problem, the significance of which is related to the special role of protein in a human life. The negative dynamics of protein value changes
Shchekoldina T.V. +2 more
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