Results 121 to 130 of about 2,965,310 (292)

Combined cortical thickness and blink reflex recovery cycle to differentiate essential tremor with and without resting tremor

Frontiers in Neurology
ObjectiveTo investigate the performance of structural MRI cortical and subcortical morphometric data combined with blink-reflex recovery cycle (BRrc) values using machine learning (ML) models in distinguishing between essential tremor (ET) with resting ...
Camilla Calomino, Andrea Quattrone, Andrea Quattrone, Maria Giovanna Bianco, Rita Nisticò, Jolanda Buonocore, Marianna Crasà, Maria Grazia Vaccaro, Alessia Sarica, Aldo Quattrone   +9 more
doaj   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Considering user experience and cognitive load in the design and development of a virtual reality application for embodied anatomy learning

Anatomical Sciences Education, EarlyView.
Abstract Virtual reality (VR) offers new possibilities for anatomy education through immersive and embodied interaction. Early‐stage evaluation of VR tools is necessary to assess user experience and perceived cognitive load and to guide iterative development.
Mélanie Gallot, Mira Hajj‐Hassan, Rawad Chaker, Christian Collet, Nady Hoyek   +4 more
wiley   +1 more source

Research on advances of essential tremor

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
Recent research shows besides the symptom of tremor, essential tremor (ET) patients also present with motor symptoms such as dysfunction of cerebellum, and non-motor symptoms (NMS) such as cognitive impairment, mood symptoms and loss of hearing.
Tian XU, Guo-hua ZHAO
doaj  

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Diagnostic significance of rhythmicity in postural hand tremor

Scientific Reports
Rhythmicity is an important feature of tremor that is widely viewed as having diagnostic significance. We hypothesized that rhythmicity might be a generic function of tremor severity, reflecting greater oscillatory entrainment of motor pathways. Postural
Patricia Weede, Günther Deuschl, Rodger J. Elble, Robin Wolke, Gerhard Schmidt, Gregor Kuhlenbäumer   +5 more
doaj   +1 more source

Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles

BMEMat, EarlyView.
Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu, Nan Li, Yu Chen, Rui Pu, Wei Wei, Yunqi Lin, Lejing Li, Yao Lu, Jianhua Hao, Lihua Li   +9 more
wiley   +1 more source

Bimanual instrument suturing technique for periodontal and implant microsurgery: A technical note

Clinical Advances in Periodontics, EarlyView.
Abstract Background In the traditional suturing technique, the dominant hand (DH) holds a needle holder, and the non‐dominant hand (NH) performs manual ties without the aid of an instrument. In periodontal and implant microsurgery, finer sutures and needles, e.g., 7‐0 in International Organization for Standardization units, are used, which could be ...
Mark Gordon, Yu‐Chang Wu, Edward Shih‐Chang Tseng, Wen‐Xiang Zhang, Diego Velasquez‐Plata, Hsun‐Liang Chan   +5 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source