Results 81 to 90 of about 2,965,310 (292)

Pathologically based criteria to distinguish essential tremor from controls: analyses of the human cerebellum

open access: yesAnnals of Clinical and Translational Neurology
Objective Essential tremor is among the most prevalent neurological diseases. Diagnosis is based entirely on neurological evaluation. Historically, there were few postmortem brain studies, hindering attempts to develop pathologically based criteria to ...
Phyllis L. Faust   +5 more
doaj   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

open access: yesAdvanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian   +12 more
wiley   +1 more source

Neuropathological findings in essential tremor

open access: yes
Essential tremor (ET) is one of the most common neurological conditions and the most common movement disorder. The pathophysiological mechanisms that underlie this entity have not yet been described.
Foivos Petridis, Ioannis Mavroudis
core   +1 more source

Examining the motor phenotype of patients with both essential tremor and Parkinson's disease. [PDF]

open access: yes, 2012
Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long-standing ET who develop PD tend to have a tremor-dominant subtype. To further clarify this association,
Rita M. Simões   +17 more
core   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

open access: yesAdvanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong   +13 more
wiley   +1 more source

Stereotactic radiosurgery in the treatment of essential tremor – a systematic review

open access: yesFrontiers in Neurology
IntroductionEssential tremor (ET) is the most common movement disorder in adults, with an estimated incidence of up to 1% of the population and 5% of people older than 65 years of age.
Mateusz Bilski   +13 more
doaj   +1 more source

The nature of tremor circuits in parkinsonian and essential tremor [PDF]

open access: yes, 2014
Tremor is a cardinal feature of Parkinson’s disease and essential tremor, the two most common movement disorders. Yet, the mechanisms underlying tremor generation remain largely unknown. We hypothesized that driving deep brain stimulation electrodes at a
Limousin, P   +23 more
core   +1 more source

Developing a neurofeedback based intervention to reduce tremor in Essential Tremor

open access: yes, 2019
Essential Tremor (ET), the most common adult movement disorder, can interfere with activities of daily living (ADLs). ET is difficult to treat and many individuals with ET try many combinations of treatments, including but not limited to ...
Sanderson, Chelsey
core  

Dementia in Essential Tremor: A Visual Record

open access: yes, 2019
Background: Research studies have shown an association between essential tremor (ET) and dementia, although dementia in ET is not often regarded as a clinically important issue. Phenomenology Shown: We present three tangible visual records of patients
Elan D. Louis   +4 more
core   +1 more source

Prevalence of Essential Tremor on Arosa Island, Spain: a Community-based, Door-to-Door Survey [PDF]

open access: yes, 2013
Background: The prevalence of essential tremor (ET) is still not well understood and the various studies performed to date have generated highly variable results.
Eugenio Torres Salgado   +19 more
core   +1 more source

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