Results 81 to 90 of about 381,853 (304)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
‘Padres de la Patria’ and the ancestral past: commemorations of independence in nineteenth-century Spanish America [PDF]
, 2002 This article examines the civic festivals held in nineteenth-century Spanish America to commemorate independence from Spain. Through such festivals political leaders hoped, in Hobsbawm's words, ‘to inculcate certain values and norms of behaviour by ...
Earle, Rebecca
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Casas y Sitios Reales en el Estado Liberal
Los Libros de la Corte.es, 2022 ***
Cristina Bienvenida Martínez García +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
MIGRACIÓN MÉXICO-ESTADOS UNIDOS: PARADOJA LIBERAL RENOVADA DEL TLCAN
Problemas del Desarrollo, 2015 RESUMENEl objetivo de esta investigación es presentar algunas de las reflexiones más importantes sobre los signos y las repercusiones teóricas y empíricas que en cuanto a la migración de mexicanos hacia Estados Unidos han resultado tras los 20 años del Tratado de Libre Comercio de América del Norte (tlcan).
openaire +4 more sources
El trasfondo axiológico del derecho de propiedad privada en el Código Civil colombiano y sus desafíos en la configuración del Estado Social de Derecho [PDF]
El desarrollo del marco teórico que agrupa las relaciones entre derecho y economía ha empezado a tener un notable desarrollo a partir de finales del siglo pasado.
Elisa Botero Duque
core
Las garantías constitucionales: restricción o fortalecimiento [PDF]
, 2007 ¿Restringir o fortalecer las garantías constitucionales? Este es un dilema que ha estado en el debate nacional desde que se creó el amparo constitucional. Por un lado, parecería que la práctica de los órganos estatales y los comentarios de los medios
Ávila Santamaría, Ramiro Fernando
core
Social mobility in Portugal (1860–1960): operative issues and trends [PDF]
, 2009 This article presents the results of a study of social mobility in Portugal from the 1860s to the 1960s. Four distinct social contexts were examined by reference to selected criteria, and marriage records were used as the source for data collection and ...
Fonseca, Helder Adegar +1 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source