Results 91 to 100 of about 270,121 (304)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Efecto de herbicidas post-emergentes aplicados en distintos estados del cultivo de trigo (Triticum aestivum L.) cv. Buck Arrayán y Buck Charrúa

open access: yesSemiárida, 2020
Se evaluó el comportamiento de los herbicidas Bromoximil; Dicamba + Metsulfurón Metil; Dicamba + MCPA; Terutrina + Triasulfurón y Piclorán + Metsulfurón Metil aplicados en estado de ápices vegetativos; 2,4-0 + Oicamba; Bromoximil y Dicamba + MCPA ...
M. C. Espain   +2 more
doaj  

Coping and Logotherapy in Terminal Patients and Primary Caregivers [PDF]

open access: yes, 2015
El objetivo del presente es describir de qué manera la intervención logoterapéutica ayuda en el afrontamiento del duelo al Paciente Terminal y a su Cuidador Primario en el área de Cuidados Paliativos en un Hospital al Norte del Estado de México ...
AMADOR VELAZQUEZ, REYNA   +5 more
core  

At the crossroads of different traditions. Social and cultural dynamics in Roman Thrace through the epigraphic practice [PDF]

open access: yes, 2019
Il presente articolo studia i processi di integrazione della Tracia nel mondo romano attraverso l'analisi di tre fenomeni tra loro correlati: diffusione della lingua latina; diffusione della cittadinanza romana; diffusione dei nomi romani. Per illustrare
Francesco Camia
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Trade-off desemprego-inflação: Uma análise da aplicação de diferentes condições de transversalidade sobre uma versão adaptada do modelo de Taylor.

open access: yesRevista de Economia Mackenzie, 2011
O objetivo deste trabalho consiste em analisar os efeitos da aplicação de con‑ dições de transversalidade sobre uma versão adaptada do modelo trade‑off de‑ semprego‑inflação de Taylor (1989).
Tácito Augusto Farias   +4 more
doaj  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Acquiring Word-Meaning Mappings for Natural Language Interfaces

open access: yes, 2011
This paper focuses on a system, WOLFIE (WOrd Learning From Interpreted Examples), that acquires a semantic lexicon from a corpus of sentences paired with semantic representations.
Thompson, C.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Maximize Resolution or Minimize Error? Using Genotyping-By-Sequencing to Investigate the Recent Diversification of Helianthemum (Cistaceae) [PDF]

open access: yes, 2019
A robust phylogenetic framework, in terms of extensive geographical and taxonomic sampling, well-resolved species relationships and high certainty of tree topologies and branch length estimations, is critical in the study of macroevolutionary patterns ...
Aparicio Martínez, Abelardo   +7 more
core   +1 more source

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