Results 91 to 100 of about 269,608 (328)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Terminalidade e espiritualidade: uma reflexão a partir dos Códigos de Ética Médica brasileiros e leitura comparada de alguns países

O Mundo da Saúde, 2009
presente artigo objetiva aprofundar o debate de questões éticas relacionadas ao processo de revisão do Código de Ética Médica Brasileiro, sob o enfoque de duas vertentes: as questões éticas de final de vida e as questões éticas implicadas pela ...
Leo Pessini
doaj  

Bondadosa acción medica de humanización de la atención

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica
Se presenta el caso de una médica especialista en dolor y cuidado paliativo que, asumiendo el compromiso de humanizar la atención en salud, realiza una acción de gran bondad respondiendo a la solicitud de un paciente en estado terminal.
José María Maya
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Bondadosa acción médica de humanización de la atención. Parte II

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica
Se presenta el caso de una médica especialista en dolor y cuidado paliativo que, asumiendo el compromiso de humanizar la atención en salud, realiza una acción de gran bondad respondiendo a la solicitud de un paciente en estado terminal.
José María Maya
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Efecto de herbicidas post-emergentes aplicados en distintos estados del cultivo de trigo (Triticum aestivum L.) cv. Buck Arrayán y Buck Charrúa

Semiárida, 2020
Se evaluó el comportamiento de los herbicidas Bromoximil; Dicamba + Metsulfurón Metil; Dicamba + MCPA; Terutrina + Triasulfurón y Piclorán + Metsulfurón Metil aplicados en estado de ápices vegetativos; 2,4-0 + Oicamba; Bromoximil y Dicamba + MCPA ...
M. C. Espain, O. A. Rodríguez, S. Tellaeche   +2 more
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Nutritional status and nutritional treatment are related to outcomes and mortality in older adults with hip fracture [PDF]

, 2017
Malnutrition is very prevalent in geriatric patients with hip fracture. Nevertheless, its importance is not fully recognized. The objective of this paper is to review the impact of malnutrition and of nutritional treatment upon outcomes and mortality in ...
Malafarina, Vincenzo, Reginster, J. Y., Cabrerizo, Sonia, Bruyère, Olivier, Kanis, John A., Martinez, J. Alfredo, Zulet, M. Angeles   +6 more
core   +2 more sources

Acquiring Word-Meaning Mappings for Natural Language Interfaces

, 2011
This paper focuses on a system, WOLFIE (WOrd Learning From Interpreted Examples), that acquires a semantic lexicon from a corpus of sentences paired with semantic representations.
Thompson, C.
core   +1 more source