Results 61 to 70 of about 1,084,800 (306)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The synthesis and characterization of some ortho-substituted phenoxyalkanoic acids and their derivatives [PDF]

Journal of the Serbian Chemical Society, 2006
The synthesis of 2-phenoxyalkanoic acids (ethanoic, propanoic, butanoic) was realized by the reaction of ortho-hydroxybenzamide respectively N-phenyl-o-hydroxybenzamide with α-halogenated acids in aqueous sodium hydroxide solution.
Lupea Xenia Alfa, Popescu Iuliana, Tarabasanu Corneliu, Ienascu Ioana, Badea Valentin   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

UPLC-MS/MS analysis of ochratoxin A metabolites produced by Caco-2 and HepG2 cells in a co-culture system [PDF]

, 2017
Ochatoxin A (OTA) is one of the most important mycotoxins based on its toxicity. The oral route is the main gateway of entry of OTA into the human body, and specialized epithelial cells constitute the first barrier.
González Arias, Cyndia A., Marín Sillué, Sònia, Ramos Girona, Antonio J., Rojas-García, A. E., Sanchís Almenar, Vicente   +4 more
core   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Suicide among agricultural, forestry, and fishery workers: a systematic literature review and meta-analysis

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVES: This review aimed to quantify suicide risk among agricultural, forestry, and fishery workers and study potential variations of risk within this population.
Justine Klingelschmidt, Allison Milner, Imane Khireddine-Medouni, Katrina Witt, Evangelos C Alexopoulos, Susanna Toivanen, Anthony D LaMontagne, Jean-François Chastang, Isabelle Niedhammer   +8 more
doaj   +1 more source

Development of Sustainable MgO–C Refractories Using MgO–C Recyclates and a Novel Eco‐Friendly Fructose–Tannin Binder Crosslinked With Citric Acid

Advanced Engineering Materials, EarlyView.
This study develops sustainable MgO–C refractories using recycled materials and eco‐friendly fructose–tannin binders. The enhanced performance of citric acid as a cross‐linker and functional additives on mechanical and thermomechanical properties was examined. Characterization included strength tests, immersion trials, and microstructural and inclusion
Dinesh K. Gunasekar, Jana Hubálková, Steffen Dudczig, Gert Schmidt, Florian Kerber, Thomas Schemmel, Patrick Gehre, Christos G. Aneziris   +7 more
wiley   +1 more source

Susceptibility of Escherichia coli and Clostridium perfringens to sucrose monoesters of capric and lauric acid

Czech Journal of Animal Science, 2014
The sucrose monoesters of capric and lauric acid were tested for their antibacterial activity towards two foodborne enteropathogenic bacteria - Escherichia coli (CCM 3954 - serotype O6 and E22 - serotype O103) and Clostridium perfringens (CNCTC 5459 and ...
E. Skřivanová, Š. Pražáková, O. Benada, P. Hovorková, M. Marounek   +4 more
doaj   +1 more source

Ester

Bohemistyka, 2023
Divadelní hra Františka Vodseďálka Ester pochází z počátku 19. století a je tak součástí pozdního lidového baroka. Vodseďálek ji založil na dyadickém principu, jenž se projevuje jednak v architektonice dramatu, rozvrženého do dvou dílů, jednak v nadměrném počtu dvojic postav.
openaire   +1 more source

Hydrogen-bonding interactions in the crystalline-phase structures of cinnamic acid derivatives [PDF]

, 1999
Secondary interactions responsible for the crystalline-phase structures of various cinnamic acids and cinnamic acid esters drawn from the Cambridge Structural Database were studied with the help of the Cerius package implemented on an SGI workstation ...
Pálinkó, István
core   +1 more source