Results 111 to 120 of about 124,633 (302)

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

Angewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern, Krisztina Németh, Tímea Imre, József Simon, Kitti Meggyes, Gergő Bárdos, László Petri, Márton Bojtár, Attila Kormos, Péter Kele   +9 more
wiley   +2 more sources

The Esterase Gs Derived from Geobacillus sp. JM6 Exhibits Hydrolytic Activity on the PET Model Substrates

Biology
The continuous increase in demand for polyethylene terephthalate (PET) has drawn global attention to the significant environmental pollution caused by the degradation of PET plastics.
Shuyan Duan, Zhaoyi Wei, Yushan Wei, Xiaoyue Cai, Yixuan Liu, Ruiran Fan   +5 more
doaj   +1 more source

Metagenomics of an alkaline hot spring in Galicia (Spain): microbial diversity analysis and screening for novel lipolytic enzymes

Frontiers in Microbiology, 2015
A fosmid library was constructed with the metagenomic DNA from the water of the Lobios hot spring (76°C, pH=8.2) located in Ourense (Spain). Metagenomic sequencing of the fosmid library allowed the assembly of 9,722 contigs ranging in size from 500 to 56,
Olalla eLópez-López, Kamila eKnapik, María-Esperanza eCerdán, María-Isabel eGonzález-Siso   +3 more
doaj   +1 more source

Esterase-Mediated Highly Fluorescent Gold Nanoclusters and Their Use in Ultrasensitive Detection of Mercury: Synthetic and Mechanistic Aspects

, 2018
The fast, accurate, and ultrasensitive detection of toxic mercury in real water samples is still challenging without the use of expensive sophisticated instruments.
Neeraj S. Thakur (4329130), Uttam C. Banerjee, Narattam Mandal (6160736), Neeraj S. Thakur, Uttam C. Banerjee (1588525), Narattam Mandal   +5 more
core   +1 more source

Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters

Angewandte Chemie, EarlyView.
Superchaotropic boron clusters are demonstrated to deliver hydrophilic glycans directly into mammalian cells, removing the need for acetylation and cytotoxic solvents such as DMSO. Azido glycans for metabolic oligosaccharide engineering, and trehalose, were delivered and the successful azido‐labelling of glycoproteins, cell surface glycans, and ...
Qiao Tang, Alexandru Ilie, Matthew I. Gibson   +2 more
wiley   +2 more sources

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis

Angewandte Chemie, EarlyView.
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood, Sathishkumar Kurusamy, Mark Berney, C. Mark Smales, Elizabeth M. Topp, Joanna F. McGouran, Steven Ferguson   +6 more
wiley   +2 more sources

Caracterização molecular de populações de Meloidogyne enterolobii e M. konaensis no estado do Ceará, Brasil

Revista Principia
A fruticultura é uma atividade econômica e social significativa em todas as regiões do Brasil. Com uma produção anual superior a 40 milhões de toneladas, o país ocupa o terceiro lugar no ranking mundial.
Francisco Jorge Carlos de Souza Junior, Aglaiso Bispo Milfont Neto, Mayara Castro Assunção   +2 more
doaj   +1 more source

Field-simulator study of insecticide resistance conferred by esterase-, MACE- and kdr-based mechanisms in the peach-potato aphid, Myzus persicae (Sulzer)

, 1999
Insecticide sprays were applied to Myzus persicae (Sulzer) populations carrying various combinations of three insecticide resistance mechanisms (esterase-based metabolic resistance and two target site mechanisms, known as MACE and kdr), supported on host
Foster, S. P., Devonshire, A. L.
core   +1 more source