Results 121 to 130 of about 192,226 (349)

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Population pharmacokinetics of levetiracetam in term neonates with hypoxic–ischemic encephalopathy and therapeutic hypothermia: The LEVNEONAT‐1 study

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to describe the pharmacokinetics (PK) of levetiracetam (LEV) in term neonates treated for neonatal seizures secondary to hypoxic–ischemic encephalopathy (HIE). Methods Fifteen neonates were included and received a loading dose ranging from 30 to 60 mg/kg followed by eight maintenance doses corresponding to one‐fourth of the loading
Léo Mimram, Moreno Ursino, Julie Leger, Emilie Bourrel‐Ponchel, Florence Flamein, Alexandra Chadie, Isabelle Guellec, Sarah Zohar, Vincent Jullien, Géraldine Favrais   +9 more
wiley   +1 more source

A genetic and demographic investigation of the Zoroastrians of Iran. [PDF]

, 1982
The aim of this study was to examine the Zoroastrians of Yazd, Kerman and Tehran to determine whether or not they differed from each other genetically and from the host population of Iran; to study the Parsis and Iranis - Zoroastrians Who had migrated to
Seyedna, S. Y., Seyedna, S Y.
core  

Isolation and Characterization of Random Citrate Synthase Variants That Increase Acetate Generation by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A method to select Escherichia coli citrate synthase variants having reduced activity was developed based initially on the increased generation of acid, observed visually by prolonged color change in the pH indicator bromocresol purple. Five hundred fifty‐two potential variants were isolated and each were cultured on glucose as sole carbon ...
Jeffrey K. Dodelin, Ronnie L. Fulton, Abigail E. Rose, Mark A. Eiteman   +3 more
wiley   +1 more source

Relationships among Morphological Characters, Isozymes Polymorphism and DNA Variability - the Impact on Lactuca Germplasm Taxonomy

Czech Journal of Genetics and Plant Breeding, 2003
Fifty one accessions of nineteen Lactuca species, the hybrid L. serriola × L. sativa and the related species Mycelis muralis were evaluated for morphological variability, esterase (EST) polymorphism, Amplified Fragment Length Polymorphism (AFLP) and ...
I. Doležalová, A. Lebeda, M. Dziechciarková, E. Křístková, D. Astley, C.C.M. Van De Wiel   +5 more
doaj   +1 more source

Phenolic‐Associated Dietary Fiber Ingredients From Agro‐Industrial Residues: Processing‐Dependent Identity and Food‐Grade Translation

ChemFoodChem, EarlyView.
Agro‐industrial residues contain dietary fiber and phenolics, but coexistence alone does not establish a phenolic‐bound ingredient. Processing‐dependent identity is verified through fraction‐specific analysis and common‐basis mass balance. Food‐grade translation requires final‐product performance, sensory acceptance, safety, and claim‐matched ...
Yitong Niu, Ireland LaBass, Sicheng Wang, Cheu Peng Leh, Ting Han   +4 more
wiley   +1 more source

Esterase activity of sediment core M21/1_MC382

, 1999
Esterase activity of sediment core M21 ...
Boetius, Antje, Pfannkuche, Olaf, Thiel, Hjalmar, Olaf Pfannkuche (6970646), Hjalmar Thiel (7887893), Lundgreen, Ulrich, Lochte, Karin, Antje Boetius (6962468), Karin Lochte (6960953), Ulrich Lundgreen (7887890)   +9 more
core   +1 more source

Development of Blue‐to‐Near‐Infrared rTCO–Caged Fluorogenic Probes for Click‐to‐Release Monitoring

Chemistry – A European Journal, EarlyView.
A series of fluorogenic rTCO‐caged click‐to‐release probes was prepared and evaluated both in a cuvette and in live cells. Some of the probes exhibited significant turn‐on and efficient fluorophore release spanning the blue‐to‐NIR region. A significant difference in the performance of the compounds in live cells was observed, highlighting the need for ...
Marek Chovanec, Veronika Šlachtová, Paul Eduardo Reyes‐Gutiérrez, Simona Bellová, Milan Vrabel   +4 more
wiley   +1 more source

Lysozymes' esterase activity

FEBS Letters, 1983
A non‐specific esterase activity of hen lysozyme (c‐type) has previously been described: histidine was claimed to be involved in this activity. The present letter reports that a histidine‐less lysozyme from the duck egg‐white (c‐type) as well as a goose lysozyme (g‐type) possess such an esterase activity determined using p‐nitrophenylacetate.
Jollès, Jacqueline, Jollès, Pierre
openaire   +2 more sources

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source