Results 121 to 130 of about 132,817 (351)

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Feruloyl esterase-catalysed synthesis of glycerol sinapate using ionic liquids mixtures

, 2009
The ability of a feruloyl esterase (AnFaeA), either in free or immobilised (cross-linked enzyme aggregates) form, to catalyse the esterification of glycerol, a major by-product of the biodiesel industry, with sinapic acid was studied in four ...
Vafiadi, C, Christakopoulos, P, Nahmias, Victoria R.,, Christakopoulos, Paul, Topakas, E, Faulds, Craig B.,, Topakas, Evangelos,, Vafiadi, Christina,, Nahmias, VR, Faulds, CB   +9 more
core   +1 more source

Elimination Profile of Deflazacort and Metabolites in Urine and Plasma Following Oral Administration: Relevance to Sports Drug Testing

Drug Testing and Analysis, EarlyView.
Results confirm that the MRL of 30 ng/mL for 21‐desacetyl‐deflazacort together with a 3‐day washout period is an appropriated strategy to detect oral deflazacort administration in sport competition. ABSTRACT Deflazacort (DEF) is a glucocorticoid prohibited in sports competitions when orally administered.
Sergi Coll, Claudia Bressan, Núria Monfort, Ana Aldea‐Perona, Marcel·lí Carbó, Rosa Ventura   +5 more
wiley   +1 more source

Crystallization and preliminary crystallographic analysis of Axe2, an acetylxylan esterase fromGeobacillus stearothermophilus. Corrigendum [PDF]

, 2014
Shifra Lansky, Onit Alalouf, Vered Solomon, A. Alhassid, Lata Govada, Naomi E. Chayen, Hassan Belrhali, Yuval Shoham, G. Shoham   +8 more
openalex   +1 more source

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

Drug Testing and Analysis, EarlyView.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug, S. Guddat, C. Görgens, K. Walpurgis, F. Toma, A. Thomas, M. Thevis   +6 more
wiley   +1 more source

The interactions between piperonyl butoxide and E4, a resistance-associated esterase from the peach-potato aphid, Myzus persicae Sulzer (Hemiptera: Aphididae)

, 2013
BACKGROUND: It has been reported previously that piperonyl butoxide (PBO) can inhibit both P450 and esterase activity. Although the method by which PBO combines with cytochrome P450 has been identified, the way in which it acts as an esterase inhibitor ...
Elisa Capparella, Field, L. M., Moores, G. D., Valerio Borzatta, Philippou, D., Leni Moroni, Borzatta, V., Capparella, E., Linda Field, Despina Philippou, Moroni, L., Graham Moores   +11 more
core   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Cross-Linked Enzyme Aggregates of Feruloyl Esterase Preparations from Thermothelomyces thermophila and Talaromyces wortmannii [PDF]

, 2018
Anastasia Zerva, Io Antonopoulou, Josefine Enman, Laura Iancu, Ulrika Rova, Paul Christakopoulos   +5 more
openalex   +1 more source

Esterase-Mediated Sustained Release of Peptide-Based Therapeutics from a Self-Assembled Injectable Hydrogel

A synthetic strategy for conjugating small molecules and peptide-based therapeutics, via a cleavable ester bond, to a lipidated β3-tripeptide is presented.
Helena C. Parkington (11674941), Marie-Isabel Aguilar (1763173), Harold A. Coleman (11674935), Mark P. Del Borgo (7835501), Robert E. Widdop (585063), Tanesh Gamot (11237108), Richard A. Hughes (1441735), Qingqing Lin (515645), Rachel L. Minehan (11674932), Simon Bowles (11674938), Susan E. Northfield (1448878), Denham Hopper (8321556), Ketav Kulkarni (1514530)   +12 more
core   +1 more source

Inhibition of acetylcholine esterase and butyrylcholine esterase with isoquinoline alkaloids

, 1985
The inhibition of the mentioned enzymes with 16 natural and modified isoquinoline alkaloids was investigated. Protoberberines are very strong inhibitors of both enzymes, quaternary tetrahydroprotoberberines and benzylisoquinolines are comparably strong ...
Jaromír Stejskal, Jan Kovář, Jiří Slavík   +2 more
core   +1 more source