Results 121 to 130 of about 124,633 (302)

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Chlorination‐Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models

Angewandte Chemie, EarlyView.
A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho, Yongyang Luo, Jeehyeon Bae, Youngmi Kim   +3 more
wiley   +2 more sources

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Effective production of recombinant esterase in Bacillus brevis using a pH-controlled fed-batch culture

Annals of Tropical Research, 2001
An automated two-component substrate (polypepton plus glucose) feeding strategy with a pH-stat modal fed-batch culture using a high pH limit was developed to effectively produce esterase from a protein-hyperproducing Bacillus brevis HPD31 harboring the ...
Edgardo E. Tulin
doaj  

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Blood esterases [PDF]

Biochemical Journal, 1942
D, Richter, P G, Croft
openaire   +2 more sources

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

The esterases of skin [PDF]

Biochemical Journal, 1944
R H, Thompson, V P, Whittaker
openaire   +2 more sources

Esterase-Mediated Sustained Release of Peptide-Based Therapeutics from a Self-Assembled Injectable Hydrogel

A synthetic strategy for conjugating small molecules and peptide-based therapeutics, via a cleavable ester bond, to a lipidated β3-tripeptide is presented.
Helena C. Parkington (11674941), Marie-Isabel Aguilar (1763173), Harold A. Coleman (11674935), Mark P. Del Borgo (7835501), Robert E. Widdop (585063), Tanesh Gamot (11237108), Richard A. Hughes (1441735), Qingqing Lin (515645), Rachel L. Minehan (11674932), Simon Bowles (11674938), Susan E. Northfield (1448878), Denham Hopper (8321556), Ketav Kulkarni (1514530)   +12 more
core   +1 more source

Inhibition of acetylcholine esterase and butyrylcholine esterase with isoquinoline alkaloids

, 1985
The inhibition of the mentioned enzymes with 16 natural and modified isoquinoline alkaloids was investigated. Protoberberines are very strong inhibitors of both enzymes, quaternary tetrahydroprotoberberines and benzylisoquinolines are comparably strong ...
Jaromír Stejskal, Jan Kovář, Jiří Slavík   +2 more
core   +1 more source