Results 141 to 150 of about 805 (190)

Rarely listed essential medicines in 158 national lists. [PDF]

J Pharm Policy Pract
Ul Haq MZ, Heredia C, Rizvi A, Workentin A, Persaud N.   +4 more
europepmc   +1 more source

Estetrol/Drospirenone safety in a population with cardiovascular risk factors [PDF]

Contraception
To evaluate cardiovascular safety outcomes in estetrol 15 mg/drospirenone 3 mg users with cardiovascular risk factors.We performed a secondary analysis of two open-label contraceptive phase-3 trials that enrolled participants 16 to 50 years to use estetrol/drospirenone for up to 13 cycles.
Mitchell D Creinin, Kristina Gemzell-Danielsson, Ali Kubba   +2 more
exaly   +4 more sources

Estetrol-drospirenone combination oral contraceptive: North American phase 3 efficacy and safety results

Contraception, 2021
ObjectiveTo assess efficacy, cycle control, and safety of an oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg.Study designWomen aged 16 to 50 years with a body mass index ≤35 kg/m2 enrolled in this multicenter, open-label ...
Mitchell D Creinin, Carolyn L Westhoff, Celine Bouchard   +2 more
exaly   +2 more sources

Clinical applications for estetrol [PDF]

Journal of Steroid Biochemistry and Molecular Biology, 2009
In this paper the potential clinical applications for the human fetal estrogen estetrol (E(4)) are presented based on recently obtained data in preclinical and clinical studies. In the past E(4) has been classified as a weak estrogen due to its rather low estrogen receptor affinity.
Herjan J T Coelingh Bennink
exaly   +3 more sources

Pooled efficacy results of estetrol/drospirenone combined oral contraception phase 3 trials [PDF]

Contraception, 2022
ObjectiveTo evaluate overall and subgroup efficacy of an estetrol (E4) 15 mg drospirenone (DRSP) 3 mg oral contraceptive in a 24/4-day regimen.Study designWe pooled efficacy outcomes from 2 pivotal phase 3 contraceptive trials with E4/DRSP conducted in ...
Maud Jost
exaly   +3 more sources

Reduced hemostatic effects with drospirenone-based oral contraceptives containing estetrol vs. ethinyl estradiol [PDF]

Contraception, 2017
peer reviewedObjective The effects of estetrol (E4), a natural fetal estrogen, combined with drospirenone (DRSP) were evaluated on plasma levels of sex hormone-binding globulin (SHBG), angiotensinogen and 12 hemostasis markers.
Cornelis Kluft, Christine Klipping, Jean-Michel Foidart   +2 more
exaly   +2 more sources

Ovulation inhibition by estetrol in an in vivo model

Contraception, 2008
Background: Currently, the synthetic steroid ethinylestradiol (EE) is the preferred estrogen in combined oral contraceptives. The aim of the present study was to evaluate the effectiveness of the natural steroid estetrol (E-4) as an ovulation inhibitor ...
Herjan J T Coelingh Bennink
exaly   +1 more source

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Syntheses of estetrol mqnoglucuronides

Steroids, 1976
Four possible monoglucuronides of estetrol (estra-1,3,5(10)-triene-3,15 alpha, 16 alpha, 17 beta-tetraol) have been prepared from appropriately protected estetrol by the Koenigs-Knorr reaction employing cadmium carbonate as a catalyst. Condensation of methyl acetobromoglucuronate with estetrol 15,16,17-triacetate provided the 3-glucuronide acetate ...
T, Nambara, K, Sudo, M, Sudo
openaire   +2 more sources

New estetrols in pregnancy urine

Steroids, 1974
Abstract Gas chromatographic-mass spectrometric analysis of steroid extracts of pregnancy urine resulted in the identification of four estetrols. Three of these compounds were epimeric 15-hydroxyestriois, the major compound of the group being 15α-hydroxyestriol.
N F, Taylor, C H, Shackleton
openaire   +2 more sources