Results 131 to 140 of about 6,088,284 (323)

Nonparametric curve estimation with bernstein estimates

open access: yesMetrika, 1997
For the estimation of the regression function in a random design model a Bernstein type estimator is proposed. The author studies various local and global asymptotic properties of this estimator: Consistency and asymptotic normality at a fixed point are proved and an asymptotic expression for the expectation of the estimator is derived.
openaire   +2 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

QUANTITATIVE DIFFERENCES IN ACQUIRING THE MOTOR TESTS WITH STUDENTS FROM THE REPUBLIC OF MACEDONIA AND REPUBLIC OF SERBIA [PDF]

open access: yesSport Mont, 2012
The research has been conducted on two sub-samples of male gender from the Republics of Macedonia and Serbia, aged from 14 to 15 years (±3 months) who had their training classes in urban areas. The number of entities participating in the tests was 119 in
Georgi Georgiev   +2 more
doaj  

Regular estimators for subclasses of linear estimators

open access: yesMetrika, 1985
The concept of regular estimator is due to \textit{J. Roy} and \textit{I. M. Chakravarti} [Ann. Math. Stat. 31, 392-398 (1960; Zbl 0093.158)]. For simple random sampling with or without replacement, regular estimators exist in the \(T_ 1\)-class of linear estimators.
openaire   +3 more sources

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga   +8 more
wiley   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

open access: yesMolecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin   +10 more
wiley   +1 more source

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