Results 111 to 120 of about 2,450,622 (319)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Statistical Advancement of a Flexible Unitary Distribution and Its Applications
AxiomsA flexible distribution has been introduced to handle random variables in the unit interval. This distribution is based on an exponential transformation of the truncated positive normal distribution with two parameters and can effectively fit data with ...
Hugo S. Salinas +5 more
doaj +1 more source
Bootstrap estimation for nonparametric efficiency estimates [PDF]
, 1995 This paper develops a consistent bootstrap estimation procedure to obtain confidence intervals for nonparametric measures of productive efficiency. Although the methodology is illustrated in terms of technical efficiency measured by output distance functions, the technique can be easily extended to other consistent nonparametric frontier models ...
WILSON, Paul, SIMAR, Leopold
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Uniformly Shifted Exponential Distribution
AxiomsThe use of life distributions has increased over the past decade, receiving particular attention in recent years, both from a practical and theoretical point of view. Life distributions can be used in a number of applied fields, such as medicine, biology,
Abdulhamid. A. Alzaid, Najla Qarmalah
doaj +1 more source
Identification and system parameter estimation : selected papers from the ... IFAC/IFORS Symposium.
Description based on: 9th (1991).Latest issue consulted: 9th (8-12 July 1991).Issued in ...
IFAC/IFORS Symposium on Identification and System Parameter Estimation. +1 more
core
Nonparametric curve estimation with bernstein estimates
Metrika, 1997 For the estimation of the regression function in a random design model a Bernstein type estimator is proposed. The author studies various local and global asymptotic properties of this estimator: Consistency and asymptotic normality at a fixed point are proved and an asymptotic expression for the expectation of the estimator is derived.
openaire +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Calibrated Weighting for Small Area Estimation
, 2005 Calibrated weighting methods for estimation of survey population characteristics are widely used. At the same time, model-based prediction methods for estimation of small area or domain characteristics are becoming increasingly popular.
Chambers, R. L.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source