Results 91 to 100 of about 441,851 (391)

Inhibition of estradiol synthesis impairs fear extinction in male rats

Learning & memory (Cold Spring Harbor, N.Y.), 2014
Emerging research has demonstrated that the sex hormone estradiol regulates fear extinction in female rodents and women. Estradiol may also regulate fear extinction in males, given its role in synaptic plasticity in both sexes.
B. Graham, M. Milad
semanticscholar   +1 more source

Oxidative Metabolism of Estradiol

Journal of Biological Chemistry, 1960
The metabolism of the estrogenic hormone is oxidative in nature in contrast to the reductive pathway for the neutral steroid hormones. It has been postulated that estrone is the precursor of estriol on the evidence that the required ketol intermediates are normal metabolites of the estrogenic hormone (2-4).
T. F. Gallagher, H. Leon Bradlow, Jack Fishman   +2 more
openaire   +3 more sources

Neuroprotective actions of estradiol revisited [PDF]

Trends in Endocrinology & Metabolism, 2011
Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural cells has recently clarified the causes of this ...
Azcoitia Elías, Iñigo, Arévalo, María Ángeles, De Nicola, Alejandro F., García Segura, Luis Miguel   +3 more
openaire   +6 more sources

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

The Association Between Dietary Inflammatory Potential and Sex Hormones in Male Children and Adolescents Aged 6–19 Years

Frontiers in Endocrinology, 2021
AimsThis study aimed to assess the relationship between dietary inflammatory index (DII) and sex hormones in male children and adolescents aged 6-19 years.MethodsWe obtained data from the 2013-2016 National Health and Nutrition Examination Survey (NHANES)
Zheng Qin, Zheng Qin, Zheng Qin, Nuozhou Liu, Ruoxi Liao, Ruoxi Liao, Ruoxi Liao, Luojia Jiang, Luojia Jiang, Luojia Jiang, Baihai Su, Baihai Su, Baihai Su   +12 more
doaj   +1 more source

Differential effects of steroids and retinoids on bovine myelopoiesis in vitro [PDF]

, 2004
Pregnancy and parturition are associated with physiological changes caused by steroid hormones. Alterations in number, maturity, and function of polymorphonuclear leukocytes observed in dairy cows at parturition suggest a common causative relationship ...
Burvenich, Christian, Duchateau, Luc, Meyer, Evelyne, VAN MERRIS, V   +3 more
core   +1 more source

Measurement of estradiol--challenges ahead.

Journal of Clinical Endocrinology and Metabolism, 2014
In their recent Endocrine Society position statement on the measurement of estradiol, Rosner et al (1) provide a good overview of the current status of estradiol assays in the context of their clinical and research applications.
F. Stanczyk, Nigel J. Clarke
semanticscholar   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Porphyromonas somerae Invasion of Endometrial Cancer Cells

Frontiers in Microbiology, 2021
Recent evidence suggests an association between endometrial cancer and the understudied bacterial species Porphyromonas somerae. This association was demonstrated in previous work that indicated a significantly enriched abundance of P.
Taylor A. Crooks, Taylor A. Crooks, Joseph D. Madison, Joseph D. Madison, Joseph D. Madison, Dana M. Walsh, William G. Herbert, William G. Herbert, Patricio R. Jeraldo, Patricio R. Jeraldo, Nicholas Chia, Nicholas Chia, William A. Cliby, Scott H. Kaufmann, Marina R. S. Walther-Antonio, Marina R. S. Walther-Antonio, Marina R. S. Walther-Antonio   +16 more
doaj   +1 more source

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin [PDF]

Environmental Science and Pollution Research, 2016
17β-Estradiol (E2) and 17α-ethinyl estradiol (EE2), which are environmental estrogens, have been determined with LC-MS in freshwater. Their sensitive analysis needs derivatization and therefore is very hard to achieve in multiresidue screening. We analyzed samples from all the large and some small rivers (River Danube, Drava, Mur, Sava, Tisza, and Zala)
Avar, Péter Ágoston, Zrínyi, Zita, Maász, Gábor, Takátsy, Anikó, Lovas, Sándor, G.-Tóth, László, Pirger, Zsolt   +6 more
openaire   +3 more sources