Arthritis &Rheumatology, EarlyView.Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty +4 more
wiley +1 more source
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
British Journal of Clinical Pharmacology, EarlyView.Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source
Journal of the Arab Society for Medical ResearchBackground/Aim Osteoporosis is a musculoskeletal disorder that is characterized by low bone mineral density (BMD) as well as an elevated risk of fractures.
Samar G. Soliman +3 more
doaj +1 more source
A new method for the separation of androgens from estrogens and for the partition of estriol from the estrone-estradiol fraction: with special reference to the identification and quantitative microdetermination of estrogens by ultraviolet absorption spectrophotometry [PDF]
, 1948 It is recognized generally that a qualitative and quantitative knowledge of the excretion pattern of the urinary estrogens is one index to an understanding of the functional activity of the ovary and adrenal cortex.
Friedgood, Harry B. +2 more
core
Estrous behavior in dairy cows: identification of underlying mechanisms and gene functions [PDF]
, 2010 Selection in dairy cattle for a higher milk yield has coincided with declined fertility. One of the factors is reduced expression of estrous behavior. Changes in systems that regulate the estrous behavior could be manifested by altered gene expression ...
Beerda, B. +3 more
core +2 more sources
BMEMat, EarlyView.This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang +8 more
wiley +1 more source
Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery
Neural Regeneration Research, 2016 Spinal cord injury (SCI) is a condition without a cure, affecting sensory and/or motor functions. The physical trauma to the spinal cord initiates a cascade of molecular and cellular events that generates a non-permissive environment for cell survival ...
Jennifer M Colón, Jorge D Miranda
doaj +1 more source
Estradiol Levels and Chemotherapy in Breast Cancer Patients: A Prospective Clinical Study
, 2023 Widyanti Soewoto, Nunik Agustriani
openalex +2 more sources
Mapping molluscan endocrinology: a systematic and critical appraisal
Biological Reviews, EarlyView.ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis +3 more
wiley +1 more source
Estrogenic activity, race/ethnicity, and Indigenous American ancestry among San Francisco Bay Area women. [PDF]
, 2019 Estrogens play a significant role in breast cancer development and are not only produced endogenously, but are also mimicked by estrogen-like compounds from environmental exposures.
Fejerman, Laura +6 more
core +2 more sources