Results 41 to 50 of about 309,036 (359)

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol [PDF]

, 2017
© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ
B Calippe, C Zhao, CJ Du, D Bakstad, D Farre, D Hartl, D Mullassery, D Xing, DA Turner, DG Spiller, E Kassi, E Munukka, ED Papadimitraki, FA Carvalho, I Caballero, JC Price, JC Price, JH Levine, K Dahlman-Wright, K Paech, KA Zarember, L Ashall, L Bjornstrom, M Junkin, M Lion, M Maggiolini, ME Quaedackers, MF Smith Jr., N Munoz, O Takeuchi, PL Zeitlin, R Galien, RC Dodel, RH Straub, S Ghisletti, S Rakoff-Nahoum, S Reardon, SK Drexler, TK Lee, WH Sun, Y Wang, Z Cai, ZX Shan   +42 more
core   +4 more sources

Breast Density and Estradiol Are Major Determinants for Soluble TNF-TNF-R Proteins in vivo in Human Breast Tissue

Frontiers in Immunology, 2022
High mammographic density and exposure to sex steroids are independent risk factors for breast cancer by yet unknown mechanisms. Inflammation is one hallmark of cancer and the tumor necrosis factor family of proteins (TNFSFs) and receptors (TNFRSFs) are ...
Jimmy Ekstrand, Jimmy Ekstrand, Maja Zemmler, Maja Zemmler, Annelie Abrahamsson, Annelie Abrahamsson, Peter Lundberg, Peter Lundberg, Peter Lundberg, Mikael Forsgren, Mikael Forsgren, Mikael Forsgren, Charlotta Dabrosin, Charlotta Dabrosin   +13 more
doaj   +1 more source

Women's hormone levels modulate the motivational salience of facial attractiveness and sexual dimorphism [PDF]

, 2014
The physical attractiveness of faces is positively correlated with both behavioral and neural measures of their motivational salience. Although previous work suggests that hormone levels modulate women's perceptions of others’ facial attractiveness ...
DeBruine, Lisa, Fisher, Claire I., Hahn, Amanda C., Jones, Benedict C., Wang, Hongyi   +4 more
core   +2 more sources

Androgen Regulation of the Mesocorticolimbic System and Executive Function

Frontiers in Endocrinology, 2018
Multiple lines of evidence indicate that androgens, such as testosterone, modulate the mesocorticolimbic system and executive function. This review integrates neuroanatomical, molecular biological, neurochemical, and behavioral studies to highlight how ...
Daniel J. Tobiansky, Daniel J. Tobiansky, Kathryn G. Wallin-Miller, Stan B. Floresco, Stan B. Floresco, Ruth I. Wood, Kiran K. Soma, Kiran K. Soma, Kiran K. Soma   +8 more
doaj   +1 more source

Association of Sex Hormones and Sex Hormone-Binding Globulin Levels With Bone Mineral Density in Adolescents Aged 12–19 Years

Frontiers in Endocrinology, 2022
BackgroundSex hormones are recognized to play a significant role in increasing bone mineral density (BMD) and promoting bone maturation during adolescence.
Ke Xu, Ke Xu, Yicheng Fu, Buzi Cao, Mingyi Zhao   +4 more
doaj   +1 more source

Species-specific differences in follicular antral sizes result from diffusion-based limitations on the thickness of the granulosa cell layer [PDF]

, 2013
The size of mature oocytes is similar across mammalian species, yet the size of ovarian follicles increases with species size, with some ovarian follicles reaching diameters more than 1000-fold the size of the enclosed oocyte. Here we show that the different follicular sizes can be explained with diffusion-based limitations on the thickness of the ...
arxiv   +1 more source

Estradiol Inhibits ER Stress-Induced Apoptosis in Chondrocytes and Contributes to a Reduced Osteoarthritic Cartilage Degeneration in Female Mice

Frontiers in Cell and Developmental Biology, 2022
Gender differences are a common finding in osteoarthritis (OA). This may result from a differential response of males and females to endoplasmic reticulum (ER) stress in articular chondrocytes.
Rita Dreier, Thomas Ising, Markus Ramroth, Yvonne Rellmann   +3 more
doaj   +1 more source

Loss of the arabidopsis protein kinases ANPs affects root cell wall composition, and triggers the cell wall damage syndrome [PDF]

, 2017
The Arabidopsis NPK1-related Protein kinases ANP1, ANP2 and ANP3 belong to the MAP kinase kinase kinase (MAPKKK) superfamily and were previously described to be crucial for cytokinesis, elicitor-induced immunity and development.
Daniel V. Savatin, Daniel V. Savatin, Felice Cervone, Giulia De Lorenzo, Nora Gigli Bisceglia, Nora Gigli Bisceglia, Timo Engelsdorf   +6 more
core   +5 more sources

Estradiol, Dopamine and Motivation [PDF]

Central Nervous System Agents in Medicinal Chemistry, 2015
The gonadal hormone estradiol modulates mesolimbic dopamine systems in the female rat. This modulatory effect is thought to be responsible for the observed effects of estradiol on motivated behaviors. Dopamine acting in the nucleus accumbens is thought to be important for the attribution of incentive motivational properties to cues that predict reward ...
Katie E. Yoest, Jill B. Becker, Jennifer A. Cummings   +2 more
openaire   +3 more sources

Restoration of serum estradiol and reduced incidence of miscarriage in patients with low serum estradiol during pregnancy: a retrospective cohort study using a multifactorial protocol including DHEA

Frontiers in Reproductive Health
BackgroundLow serum estradiol in early pregnancy is associated with an elevated risk of miscarriage. We sought to determine whether efforts to restore low blood estradiol via estradiol or dehydroepiandrosterone (DHEA) supplementation would reduce the ...
Phil Boyle, Phil Boyle, Karolina Andralojc, Karolina Andralojc, Susanne van der Velden, Shahpar Najmabadi, Theun de Groot, Theun de Groot, Craig Turczynski, Craig Turczynski, Joseph B. Stanford, Joseph B. Stanford   +11 more
doaj   +1 more source