Results 41 to 50 of about 173,634 (281)

Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples

Advanced Science, EarlyView.
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen, Yi Zhang, Yu‐Jie Yan, Meng‐Ting Zhang, Jian‐Bo Chen, Yi‐Rong Jiang, Jie Wu, Hui‐Feng Wang, Jian‐Zhang Pan, Zhi‐Gang Chen, Jian Huang, Qun Fang   +11 more
wiley   +1 more source

Modeling Sex-Bias in Anxiety: Pros and Cons of a Larval Zebrafish Model

Chronic Stress
Anxiety disorders are the most prevalent psychiatric disorders, exhibiting strong female bias. Clinical studies implicate declining estradiol levels in the exacerbation of anxiety symptoms in the premenstrual phase of the menstrual cycle.
Lesha Pretorius, Aidan G. Balshaw, Kelly S. Ross, Carine Smith   +3 more
doaj   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Impact of creatine supplementation on menopausal women’s body composition, cognition, estrogen, strength, and sleep

Journal of the International Society of Sports Nutrition
Background Despite extensive research on creatine, evidence for use among females is understudied. Understanding the effects of creatine metabolism in peri- and post menopause yields important implications for creatine supplementation regarding ...
Lauren Hall, Sadie Klassen, Jennifer Holbein, John Waters   +3 more
doaj   +1 more source

Effects of Panax ginseng, zearalenol, and estradiol on sperm function

Journal of Ginseng Research, 2016
Background: Estrogen signaling pathways are modulated by exogenous factors. Panax ginseng exerts multiple activities in biological systems and is classified as an adaptogen.
Sandra L. Gray, Brett R. Lackey, William R. Boone   +2 more
doaj   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

Advanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang, Yi Liu, Ziying Sun, Jia Li, Zhihao Lu, Jiayuan Huang, Shixian Hu, Peihua Cao, Xiaolong Cao, Shangru Li, Jianzhao Ruan, Jinhui Liu, Jingyu Xie, Haitao Sun, Tianyu Chen, Shengfa Li, Zhaohua Zhu, Zhibo Wen, Rocky S. Tuan, David John Hunter, Zhong Alan Li, Dongquan Shi, Changhai Ding   +22 more
wiley   +1 more source

The Effects of Continuous Combined Oral Estradiol and Norethisterone on Pulsatility Index in Internal Carotid and Uterine Arteries in Early Postmenopausal Taiwanese Women—A Preliminary Study

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: This study analyzed whether continuous combined oral estradiol and norethisterone had any effect on the pulsatility index (PI) of the internal carotid and uterine arteries in Taiwanese early postmenopausal women. Materials and Methods: A group
Chen-Yu Huang, Chong-Yau Fu, Jen-Yu Tseng, Tzay-Shing Yang, Kuan-Chong Chao   +4 more
doaj   +1 more source

Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

Advanced Science, EarlyView.
Osteocyte heterogeneity in bone remains poorly understood. This study identifies six distinct osteocyte subsets in mice, revealing a key subpopulation (BHR‐Ocys) that drives bone loss in osteoporosis. BHR‐Ocys promote osteoclast‐mediated resorption via a novel Sema5a‐Plxna1 signaling axis.
Zengxin Jiang, Biyu Rui, Xuecheng He, Jiajun Wang, Xiangdong Wu, Rui Shao, Xue Meng, Xiaochun Peng, Hengfeng Yuan   +8 more
wiley   +1 more source

Sleep deprivation enhances peripheral serotonin secretion to regulate the large follicle steroidogenesis of rats

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: Sleep deprivation (SD) leads to the disturbance of the estrous cycle. Serotonin, the levels of which increase with SD, has been shown to inhibit luteinizing hormone production and the receptor has been found in the follicles.
Chueh-Ko Yang, Rick Sai-Chuen Wu, Cheng-Hsuan Wu, Theodore Rong-Yei Lin, Horng-Der Tsai   +4 more
doaj   +1 more source

P-634 Safety of ART cycles with extremely high estradiol levels - A retrospective cohort study [PDF]

, 2022
Ariel Hourvitz, Alon Kedem, Sarit Avraham, Yariv Gidoni, Jonathan Barkat, Gil Yerushalmi, Ohad Baruchin, Itai Gat, Micha Baum, Ettie Maman, Michal Youngster   +10 more
openalex   +1 more source