Results 11 to 20 of about 28,421 (204)

Characterization and modulation of microglial phenotypes in an animal model of severe sepsis

Journal of Cellular and Molecular Medicine, Volume 24, Issue 1, Page 88-97, January 2020., 2020
Abstract We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of minocycline on these phenotypes. Rats were subjected to CLP, and some animals were treated with minocycline (10 ug/kg) by i.c.v. administration.
Monique Michels, Mariane Rocha Abatti, Pricila Ávila, Andriele Vieira, Heloisa Borges, Celso Carvalho Junior, Diogo Wendhausen, Juciano Gasparotto, Camila Tiefensee Ribeiro, José Claudio Fonseca Moreira, Daniel Pens Gelain, Felipe Dal‐Pizzol   +11 more
wiley   +1 more source

Phytochemical Analysis, Antioxidant Activity, Antimicrobial Activity, and Cytotoxicity of Chaptalia nutans Leaves

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2020, Issue 1, 2020., 2020
Context. Chaptalia nutans (L.) Pol. (family: Asteraceae) is widely used in traditional medicine as laxative and anticough medications and especially in the traumatisms, wounds, and hemorrhages in topical preparations. Objective. This work was to evaluate the chemical constitution of the hydromethanolic (30/70 methanol‐water) macerating extract obtained
Letiele Bruck de Souza, Amanda Leitão Gindri, Thainara de Andrade Fortes, Thais Felli Kubiça, Jefferson Enderle, Rafael Roehrs, Sidnei Moura e Silva, Vanusa Manfredini, Elton Luís Gasparotto Denardin, Srinivas Mutalik   +9 more
wiley   +1 more source

Evaluation of expression of mismatch repair gene MLH1 and levels of oxidative DNA damage in normal and neoplastic tissues of patients with colorectal cancer [PDF]

, 2009
The oxidative DNA damage caused by oxygen free radicals is one of the most important mechanisms responsible for the initial steps of colorectal carcinogenesis.
Bartchewsky Júnior, Waldemar, Cordeiro, Adriana Teixeira, Margarido, Nelson Fontana, Martinez, Carlos Augusto Real, Miranda, Daniel Duarte Da Conceição, Priolli, Denise Gonçalves, Ribeiro, Marcelo Lima   +6 more
core   +4 more sources

Evolution of oxidative stress biomarkers and correlation with competitive performance in two moments of the swimming training season [PDF]

, 2009
Estudos têm demonstrado aumento na formação de espécies reativas de oxigênio após o esforço físico intenso. Esses eventos podem aumentar a suscetibilidade das células musculares a danos oxidativos como a peroxidação lipídica.
DEGIOVANNI, Gabriel Carvalho, DEMINICE, Rafael, GARLIPP-PICCHI, Monike Ribeiro, JORDÃO, Alceu Afonso, NÓBREGA, Mariana T., TEIXEIRA, Marcelo   +5 more
core   +2 more sources

Current aspects of the relationship between physical exercise, oxidative stress and magnesium [PDF]

, 2008
Este trabalho visa a contribuir com informações atualizadas sobre a relação entre exercício, estresse oxidativo e magnésio. São escassos os trabalhos que discutem a produção de radicais livres nesse contexto.
AMORIM, Aline Guimarães, TIRAPEGUI, Julio   +1 more
core   +2 more sources

Estresse oxidativo: conceito, implicações e fatores modulatórios [PDF]

Revista de Nutrição, 2010
O estresse oxidativo decorre de um desequilíbrio entre a geração de compostos oxidantes e a atuação dos sistemas de defesa antioxidante. A geração de radicais livres e/ou espécies reativas não radicais é resultante do metabolismo de oxigênio. A mitocôndria, por meio da cadeia transportadora de elétrons, é a principal fonte geradora. O sistema de defesa
Barbosa, Kiriaque Barra Ferreira, Costa, Neuza Maria Brunoro, Alfenas, Rita de Cássia Gonçalves, De Paula, Sérgio Oliveira, Minim, Valéria Paula Rodrigues, Bressan, Josefina   +5 more
openaire   +3 more sources

Serum markers of oxidative stress in infertile women with endometriosis [PDF]

, 2010
OBJETIVO: comparar marcadores séricos de estresse oxidativo entre pacientes inférteis com e sem endometriose e avaliar a associação destes marcadores com o estadiamento da doença.
ANDRADE, Aline Zyman de, DIB, Luciana Azôr, FERRIANI, Rui Alberto, JORDÃO JUNIOR, Alceu Afonso, NAVARRO, Paula Andrea de Albuquerque Salles, RODRIGUES, Jhenifer Kliemchen, ROMÃO, Gustavo Salata   +6 more
core   +2 more sources

Data on cell viability of human lung fibroblasts treated with polyphenols-rich extract from Plinia trunciflora (O. Berg) Kausel)

Data in Brief, 2016
Jaboticaba (Plinia trunciflora (O. Berg) Kausel) is a Brazilian native berry, which presents high levels of polyphenols. Here we provide data related to the effects of the polyphenols-rich extract from jaboticaba on the cell viability, mitochondrial ...
Caroline Calloni, Luciana Fernandes Silva Santos, Luana Soares Martínez, Mirian Salvador   +3 more
doaj   +1 more source

Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA–induced dopaminergic denervation

Scientific Reports, 2017
The receptor for advanced glycation endproducts (RAGE) is a pattern-recognition receptor associated with inflammation in most cell types. RAGE up-regulates the expression of proinflammatory mediators and its own expression via activation of NF-kB. Recent
Juciano Gasparotto, Camila Tiefensee Ribeiro, Rafael Calixto Bortolin, Nauana Somensi, Thallita Kelly Rabelo, Alice Kunzler, Natália Cabral Souza, Matheus Augusto de Bittencourt Pasquali, José Claudio Fonseca Moreira, Daniel Pens Gelain   +9 more
doaj   +1 more source

Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model

Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019
Objective. In this study, we evaluated the efficacy of simvastatin in the treatment of nonalcoholic steatohepatitis induced by methionine and choline‐deficient diet in mice and its possible effect on factors involved in the pathogenesis of the disease including oxidative stress and endoplasmic reticulum stress. Method.
Graziella Rodrigues, Andrea Janz Moreira, Silvia Bona, Elizângela Schemitt, Cláudio Augusto Marroni, Fábio Cangeri Di Naso, Alexandre Simões Dias, Thienne Rocha Pires, Jaqueline Nascimento Picada, Norma Possa Marroni, Yvonne Alexander   +10 more
wiley   +1 more source