The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation [PDF]
, 2016 Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-
Anagnostopoulou, Aikaterini +9 more
core +1 more source
Journal of Education, Health and Sport, 2021 The following article presents results of the complex research on postulation of immunohistochemical features of the ovaries’ structure in case of fetuses with a gestational term of 21-28 weeks from mothers with HILGT comparing to ones in case of fetuses
V. O. Poliyasnyi, L. S. Kupriianova
doaj +1 more source
Regenerating Rat Liver: Correlations Between Estrogen Receptor Localization and Deoxyribonucleic Acid Synthesis [PDF]
, 1984 Estrogen receptor activity was quantitated in the cytosol and nucleus of normal rat liver and in regenerating rat liver at several time intervals after 75% hepatectomy. Cytosolic estradiol binding in regenerating liver decreases at 12, 24, and 48 h after
Di Leo, A +6 more
core +1 more source
Sex Differences in Memory: Do Female Reproductive Factors Explain the Differences?
Frontiers in Endocrinology, 2022 BackgroundThe sex differences in memory impairment were inconclusive, and the effect of female reproductive factors (age at menarche, age at menopause, and reproductive period) on the differences was not clear.
Jie Li +10 more
doaj +1 more source
Estrogen and estrogen receptors in kidney diseases [PDF]
Renal Failure, 2021 Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to global health within this century. Studies have suggested that estrogen and estrogen receptors (ERs) play important roles in many physiological processes in the kidney.
Hao-Yang Ma, Shuang Chen, Yang Du
openaire +3 more sources
A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]
, 2018 Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A. +12 more
core +4 more sources
KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function [PDF]
, 2018 Estrogen receptor alpha (ER alpha) is a ligand-activated nuclear receptor that directs proliferation and differentiation in selected cancer cell types including mammary-derived carcinomas.
Abdel-Wahab, Omar +13 more
core +2 more sources
Association between sex steroid hormones and subsequent hyperglycemia during pregnancy
Frontiers in Endocrinology, 2023 ObjectiveSex steroid hormones may play a role in insulin resistance and glucose dysregulation. However, evidence regarding associations between early-pregnancy sex steroid hormones and hyperglycemia during pregnancy is limited.
Ying Meng +17 more
doaj +1 more source
Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]
, 2014 Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright +17 more
core +1 more source
Developmental Effects of Prenatal Exposure to Bisphenol A on the Uterus of Rat Offspring
Neoplasia: An International Journal for Oncology Research, 2004 Exposure to estrogenic compounds during critical periods of fetal development could result in adverse effects on the development of reproductive organs that are not apparent until later in life.
Gilbert Schönfelder +3 more
doaj +1 more source