Results 151 to 160 of about 446,168 (357)

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

High Affinity Estrogen Receptors in Uterus of Early Malnourished Rats [PDF]

, 1978
S Muzzo, A Zvaighaft
openalex   +1 more source

Adipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen‐Deficient Environments via the Amplifier Extracellular Vesicles

Advanced Science, EarlyView.
Chronic systemic inflammation, worsened by estrogen deficiency, underlies and exacerbates periodontitis. Proinflammatory macrophages within visceral adipose tissue are hyperactivated due to hyper‐DNA methylation, releasing small extracellular vesicles (sEVs) similar to those of their parent cells.
Danfeng Li, Tian Yang, Yuqian Li, Xinwei Lyu, Cheng Hu, Jiayin Yan, Jiali Tan   +6 more
wiley   +1 more source

Antibodies to estrogen receptor: Immunochemical similarity of estrophilin from various mammalian species [PDF]

, 1977
Geoffrey L. Greene, Liselotte E. Closs, Honorée Fleming, Eugene R. DeSombre, Elwood V. Jensen   +4 more
openalex   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

Anti-estrogen interaction with uterine estrogen receptors. Studies with a radiolabeled anti-estrogen (CI-628).

, 1978
Benita S. Katzenellenbogen, John A. Katzenellenbogen, E. Ferguson, N. Krauthammer   +3 more
openalex   +1 more source

Solubilization of the Chromatin‐Bound Estrogen Receptor from Chicken Liver and Fractionation on Hydroxylapatite [PDF]

, 1976
Michael Gschwendt
openalex   +1 more source

Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface

Advanced Science, EarlyView.
Drop‐on‐demand printing is used to replicate the spatial compartmentalization of the breast cancer‐host interface. Hydrogel confinement affects phenotypic changes in cells at the spheroid interface that drives a two‐fold increase in chemotherapeutic resistance compared to control unconfined spheroids.
Bram G. Soliman, Peilin Tian, Jiuyu Cui, Kristopher A. Kilian, J. Justin Gooding   +4 more
wiley   +1 more source

SOLUBLE BIOSPECIFIC MACROMOLECULE FOR PURIFICATION OF ESTROGEN RECEPTOR [PDF]

, 1978
J. Mešter, P. Hubert, E.E. Baulieu
openalex   +1 more source