Results 221 to 230 of about 276,776 (266)
Some of the next articles are maybe not open access.
Estrogen and estrogen receptors of breast cancer
Journal of Surgical Oncology, 1975AbstractHuman breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen‐binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment.
V, Sahadevan +3 more
openaire +2 more sources
Estrogen receptors in the pancreas
Journal of Steroid Biochemistry, 1974Minced rat pancreas retained a large portion of estradiol (E2) after incubation with either 5 nM or 1 μM concentrations of radioactive E2. The mince was homogenized in low salt buffer and separated into nuclei, mitochondria, microsomes, and cytosol by centrifugations at 1000 g, 10,000 g, and 105,000 g, respectively.
AVERY A. SANDBERG, HANNAH E. ROSENTHAL
openaire +1 more source
Molecular and Cellular Endocrinology, 1998
The purpose of this paper is to review potential novel functional pathways by which estradiol and estrogenic compounds elicit biological responses in mammals. We will limit our approach to those novel functions suggested by phenotypes associated with estrogen receptor-alpha (ER alpha) gene mutations and polymorphisms.
J A, Taylor, K J, Lewis, D B, Lubahn
openaire +2 more sources
The purpose of this paper is to review potential novel functional pathways by which estradiol and estrogenic compounds elicit biological responses in mammals. We will limit our approach to those novel functions suggested by phenotypes associated with estrogen receptor-alpha (ER alpha) gene mutations and polymorphisms.
J A, Taylor, K J, Lewis, D B, Lubahn
openaire +2 more sources
Estrogen or estrogen receptor?
Trends in Endocrinology & Metabolism, 2003View Large Image | Download PowerPoint SlideAs a clinical breast oncologist, I was eager to review Endocrine Therapy in Breast Cancer. Hormonal manipulation has been the predominant form of breast cancer treatment for >50 years. Surgical ablation, high-dose estrogens, LHRH agonists and antiestrogens have all shown clinical benefit.
openaire +1 more source
Fulvestrant: an estrogen receptor antagonist that downregulates the estrogen receptor
Seminars in Oncology, 2003Fulvestrant, a novel antiestrogen classified as an estrogen receptor antagonist without known agonist effects, was recently approved in the United States for the treatment of postmenopausal, hormone receptor-positive women with progressive metastatic breast cancer after antiestrogen therapy.
openaire +2 more sources
Estrogen Receptors and Anti-Estrogen Therapies
2006The realisation that breast cancer growth is regulated by the hormone estrogen led to the development of tamoxifen as the first target-directed cancer drug. Clearly, there is considerable headway to be made in further elucidating estrogen receptor function, in particular in identifying the mechanisms underlying endocrine resistance.
Lakjaya, Buluwela +3 more
openaire +2 more sources
Critical Reviews in Eukaryotic Gene Expression, 2002
Today we have to consider the existence of two estrogen receptors, alpha and beta, in our attempts to understand the role of estrogen receptors in physiology and pathology, and to explain the pharmacology of estrogens, antiestrogens, and SERMs. Both ERalpha and ERbeta belong to the large family of nuclear receptors that function as hormone-dependent ...
Stefan, Nilsson, Jan-Ake, Gustafsson
openaire +2 more sources
Today we have to consider the existence of two estrogen receptors, alpha and beta, in our attempts to understand the role of estrogen receptors in physiology and pathology, and to explain the pharmacology of estrogens, antiestrogens, and SERMs. Both ERalpha and ERbeta belong to the large family of nuclear receptors that function as hormone-dependent ...
Stefan, Nilsson, Jan-Ake, Gustafsson
openaire +2 more sources
Estrogen receptor phosphorylation
Steroids, 2003Estrogen receptor alpha (ERalpha) is phosphorylated on multiple amino acid residues. For example, in response to estradiol binding, human ERalpha is predominately phosphorylated on Ser-118 and to a lesser extent on Ser-104 and Ser-106. In response to activation of the mitogen-activated protein kinase pathway, phosphorylation occurs on Ser-118 and Ser ...
openaire +2 more sources
Journal of Mammary Gland Biology and Neoplasia, 1998
Estrogen receptor (ER)3 gene expression in breast epithelium is an intricately regulated event. The human ER gene is transcribed from at least three different promoters which are expressed in a cell- and tissue-specific manner, and result in mRNA isoforms with unique 5'-untranslated exons.
T A, Hopp, S A, Fuqua
openaire +2 more sources
Estrogen receptor (ER)3 gene expression in breast epithelium is an intricately regulated event. The human ER gene is transcribed from at least three different promoters which are expressed in a cell- and tissue-specific manner, and result in mRNA isoforms with unique 5'-untranslated exons.
T A, Hopp, S A, Fuqua
openaire +2 more sources
JAMA: The Journal of the American Medical Association, 1977
To the Editor.— Kiang and Kennedy (238:59-60, 1977) have presented an interesting idea that may prove to be useful in the differential diagnosis of adenocarcinomas of unknown primary site. Unfortunately, however, the evidence offered hardly appears to justify their claim that positive estrogen receptor assays can indicate that metastases arose from ...
openaire +2 more sources
To the Editor.— Kiang and Kennedy (238:59-60, 1977) have presented an interesting idea that may prove to be useful in the differential diagnosis of adenocarcinomas of unknown primary site. Unfortunately, however, the evidence offered hardly appears to justify their claim that positive estrogen receptor assays can indicate that metastases arose from ...
openaire +2 more sources