Results 241 to 250 of about 262,665 (314)

Bee‐Derived Antioxidants as a Protective Strategy Against Doxorubicin‐Induced Ovarian Damage

Chemistry &Biodiversity, EarlyView.
Graphical abstract of Bee‐Derived Antioxidants as a Protective Strategy Against Doxorubicin‐Induced Ovarian Damage ABSTRACT Antineoplastic agents can induce tissue damage through oxidative stress mechanisms. Doxorubicin, a widely used chemotherapeutic agent, has been shown to cause permanent damage to reproductive tissues.
Meltem Arıkan Malkoc, Serap Özer Yaman, Şafak Ersöz, Sevgi Kolaylı   +3 more
wiley   +1 more source

Correction: of HSD3B1 upregulation via LRH1 sustains estrogen receptor signaling and promotes endocrine resistance in breast cancer. [PDF]

J Biol Chem
Li X, Chung YM, Patel M, Sharifi N.
europepmc   +1 more source

Discovery of the Postcoital Contraceptive Effect of Rhus pentaphylla in a Study of Acute, Subchronic, and Neurodevelopmental Toxicity of Ethanolic Leaf Extract

Chemistry &Biodiversity, EarlyView.
ABSTRACT In the present study, the acute, subchronic, and neurodevelopmental toxicity of Rhus pentaphylla, a Moroccan medicinal plant, was investigated in Swiss albino mice. HPLC analysis showed the presence of phenolic compounds with rutin as the principal component.
Fatimazahra Agouram, Aicha Ezoubeiri, Abderrahman Chait, Stefania Garzoli, Zahra Sokar   +4 more
wiley   +1 more source

Decoding estrogen receptor and GPER biology: structural insights and therapeutic advances in ERα-positive breast cancer. [PDF]

Front Oncol
Saha T, Lukong KE.
europepmc   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Glucose absorption in the duodenum is modulated by an estrogen receptor α-dependent regulation of glucose transporter functional expression. [PDF]

BMJ Open Diabetes Res Care
Ding J, Yang X, Shan W, Xu J, Du Q, Chen C, Liao Q, Lou J, Jin Z, Chen M, Xie R.   +10 more
europepmc   +1 more source

Functionalizing Injectable Hydrogels with Cobalt‐Based Metallacarboranes for Targeted Delivery in Triple‐Negative Breast Cancer

ChemBioChem, EarlyView.
This study reports a biocompatible HA–lysine hydrogel loaded with cobalt metallacarborane (CoSAN) for targeted release into triple‐negative breast cancer cells. The system maintains CoSAN cytotoxicity, as confirmed by cell assays and imaging, representing an attractive approach toward a localised TNBC treatment.
Neville Murphy, Roberto González‐Gómez, Nivethitha Ashok, Enda O’Connell, Howard Fearnhead, William J. Tipping, Karen Faulds, Wenming Tong, Abhay Pandit, Róisín M. Dwyer, Duncan Graham, Pau Farràs   +11 more
wiley   +1 more source

Author Correction: Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis. [PDF]

Mol Syst Biol
Sommerauer C, Gallardo-Dodd CJ, Savva C, Hases L, Birgersson M, Indukuri R, Shen JX, Carravilla P, Geng K, Nørskov Søndergaard J, Ferrer-Aumatell C, Mercier G, Sezgin E, Korach-André M, Petersson C, Hagström H, Lauschke VM, Archer A, Williams C, Kutter C.   +19 more
europepmc   +1 more source

Asymmetric [3,3]‐Sigmatropic Rearrangement for the Synthesis of Quaternary Center‐Containing Polycyclic Molecules: Application to the Total Synthesis of Myrmenaphthol A

ChemistryEurope, EarlyView.
A small library of tricyclic natural product‐like molecules with quaternary stereocenters is rapidly synthesized. An excellent chirality transfer from sulfur to carbon atom is observed, furnishing the desired products in 90–99% enantiomeric excesses and 51–78% isolated yields.
Weiping Zhou, Gia Hao Huynh, Arnaud Voituriez   +2 more
wiley   +1 more source