Results 241 to 250 of about 446,168 (357)

Functionalized in Triplicate: A Ring‐By‐Ring Approach to Tailored Prodiginine Derivatives for Site‐Specific Conjugation Through Click Chemistry

Chemistry – A European Journal, EarlyView.
Prodigiosin is a potent cytotoxic alkaloid but lacks target selectivity. We advance functionalization of all three pyrrole rings of prodigiosin to enable site‐specific conjugation via click chemistry. The presented azide‐ and maleimide‐functionalized prodiginines are suitable for generating covalent prodiginine conjugates and attaching auspicious ...
T. Moritz Weber, Jörg Pietruszka
wiley   +1 more source

Epigenetic Modulation of Estrogen Receptor Signaling in Ovarian Cancer. [PDF]

Int J Mol Sci
Skrzypczak M, Wolinska E, Adaszek Ł, Ortmann O, Treeck O.   +4 more
europepmc   +1 more source

Purification and Characterization of Mouse Uterine Estrogen Receptor under Conditions of Varying Hormonal Status [PDF]

, 1987
TSUNEYOS HIHORIGOME, T S Golding, Valerie Quarmby, Dennis B. Lubahn, Kenneth S. McCarty, Kenneth S. Korach   +5 more
openalex   +1 more source

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

ChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia, Anna Maria Schito, Susanna Penco, Chiara Brullo, Marcus Baumann   +4 more
wiley   +1 more source

Development of Carborane‐Based Halogenated Naphthyridinone‐Analogues as Cannabinoid Receptor Type 2 (CB2R) Ligands

ChemMedChem, EarlyView.
There is no suitable radioligand for positron emission tomography imaging of CB2R overexpression for routine clinical usage. Herein, the synthesis, characterization, binding affinity, and docking studies of carborane‐based halo‐substituted naphthyridinone derivatives as CB2R ligands are presented.
Lea Ueberham, Winnie Deuther‐Conrad, Peter Lönnecke, Aleksandr Kazimir, Evamarie Hey‐Hawkins   +4 more
wiley   +1 more source

Estradiol, via estrogen receptor β signaling, mediates stress-susceptibility in the male brain. [PDF]

Mol Psychiatry
Georgiou P, Postle AF, Mou TM, Potter LE, An X, Zanos P, Patton MS, Pultorak KJ, Clark SM, Ngyuyen V, Powels CF, Prokai-Tatrai K, Kirmizis A, Merchenthaler I, Prokai L, McCarthy MM, Mathur BN, Gould TD.   +17 more
europepmc   +1 more source

Evaluation of the Pathologic and Prognostic Correlates of Estrogen Receptors in Primary Breast Cancer

, 1982
James R. Skinner, Harold J. Wanebo, William L. Betsill, Morton C. Wilhelm, Charles R. Drake, Robert M. MacLeod   +5 more
openalex   +2 more sources

Highly Sensitive, Low‐Cost Deep‐UV Resonant Raman Microspectroscopy Systems

Chemistry–Methods, EarlyView.
Low‐cost deep UV resonant Raman microscope for chemical sensing and imaging has been developed and its performance has been experimentally validated for several potential applications. Multimodal imaging capabilities of a new instrument have been demonstrated as well.
Joseph Harrington, Vsevolod Cheburkanov, Mykyta Kizilov, Ilya Kulagin, Georgi I. Petrov, Vladislav V. Yakovlev   +5 more
wiley   +1 more source

Estrogen receptor 1 signaling in hepatic stellate cells designates resistance to liver fibrosis. [PDF]

Cell Discov
Li T, Wang G, Zhao H, Liu F, Deng Z, Chen D, Zhou X, Cao Y, Fu W, Zhang H, Yang J.   +10 more
europepmc   +1 more source

Deciphering the transcriptomic landscape of early HR+/HER2− breast cancer in very young women

Cancer Communications, EarlyView.
Iris Garrido‐Cano, Marta Tapia, Juan Carbonell, Carlos Peña, Sandra Torres‐Ruiz, Anna Ágreda‐Roca, Ana Lameirinhas, Cristina Tebar, Octavio Burgués, Cristina Hernando, Ana Lluch, Fara Brasó‐Maristany, Aleix Prat, Begoña Bermejo, María Teresa Martínez, Juan Miguel Cejalvo   +15 more
wiley   +1 more source