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Treatment of estrogen receptor-positive breast cancer.
Current Medicinal Chemistry, 2013Estrogen receptor (ER) expression is the main indicator of potential responses to endocrine therapy (ET), and approximately 70% of human breast cancers (BCs) are hormone-dependent and ER-positive.
F. Lumachi +4 more
semanticscholar +1 more source
Estrogen Receptors and Anti-Estrogen Therapies
2006The realisation that breast cancer growth is regulated by the hormone estrogen led to the development of tamoxifen as the first target-directed cancer drug. Clearly, there is considerable headway to be made in further elucidating estrogen receptor function, in particular in identifying the mechanisms underlying endocrine resistance.
Simak Ali +3 more
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Estrogen receptor α is essential for induction of oxytocin receptor by estrogen
NeuroReport, 1998The induction of oxytocin receptor (OTR) synthesis in the periphery and in the brain by estrogen is critical for reproductive success. Oxytocin receptors are involved in the control of parturition, milk ejection, and sexual and maternal behaviors.
Emilie F. Rissman +3 more
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JAMA: The Journal of the American Medical Association, 1977
To the Editor.— Kiang and Kennedy (238:59-60, 1977) have presented an interesting idea that may prove to be useful in the differential diagnosis of adenocarcinomas of unknown primary site. Unfortunately, however, the evidence offered hardly appears to justify their claim that positive estrogen receptor assays can indicate that metastases arose from ...
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To the Editor.— Kiang and Kennedy (238:59-60, 1977) have presented an interesting idea that may prove to be useful in the differential diagnosis of adenocarcinomas of unknown primary site. Unfortunately, however, the evidence offered hardly appears to justify their claim that positive estrogen receptor assays can indicate that metastases arose from ...
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ESTROGEN RECEPTORS IN RAT BONE: THEIR INTERACTION WITH ESTROGEN RECEPTOR MODULATORS
Endocrine Research, 2001Estrogen receptors (ER) were studied in rat bone cytosol using immunoprecipitation, and Western blot technique. Ligand specificity of bone ER was studied using various known modulators of ER. Competitive experiments were performed under exchange conditions in bone tissue obtained from one day old rats.
Anil Kumar Dwivedi +4 more
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Transcriptional Suppression of the Estrogen Receptor by Truncated Estrogen Receptor-Alpha
Hormone and Metabolic Research, 2002The estrogen receptor (ER) is composed of six major functional domains - the A/B domain as the activation function 1 domain, domain C as the DNA-binding domain, domain D as a hinge domain, and domain E/F as the ligand-dependent transcriptional domains. A novel protein (designated as SRB-RGS) that interacted with domains C and D of ER alpha (ER alpha C ...
Yohsuke Minatogawa +4 more
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1974
Publisher Summary Estrogen receptor proteins exist in at least three different molecular forms (8.6 S, 5.3 S, and 4.5 S) and are present in the cytoplasm of target tissues in very low amounts. Attempts to purify these relatively labile proteins by conventional methods have resulted only in modest purification and recovery has been poor.
PARIKH I +4 more
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Publisher Summary Estrogen receptor proteins exist in at least three different molecular forms (8.6 S, 5.3 S, and 4.5 S) and are present in the cytoplasm of target tissues in very low amounts. Attempts to purify these relatively labile proteins by conventional methods have resulted only in modest purification and recovery has been poor.
PARIKH I +4 more
openaire +4 more sources
Androgen Receptor and Estrogen Receptors
2002The androgen receptor (AR) and the estrogen receptors (ER) are members of the nuclear receptor (NR) family. These NRs are distinguished from the other transcription factors by their ability to control gene expression upon ligand binding (steroids, retinoids, thyroid hormone, vitamin D, fatty acids, and other small hydrophobic molecules). Their combined
H. M. Oosterkamp, R. Bernards
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JAMA: The Journal of the American Medical Association, 1977
L E, Posey +8 more
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L E, Posey +8 more
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