Results 31 to 40 of about 2,368,340 (74)
Steroid Receptors and Vertebrate Evolution [PDF]
arXiv, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv
Clinical Cancer Research, 2014 Purpose: We undertook this study to determine the prevalence of estrogen receptor (ER) α (ESR1) mutations throughout the natural history of hormone-dependent breast cancer and to delineate the functional roles of the most commonly detected alterations ...
R. Jeselsohn +30 more
semanticscholar +1 more source
Comparative distribution of estrogen receptor‐α and ‐β mRNA in the rat central nervous system
The Journal of comparative neurology, 1997 Estrogen plays a profound role in regulating the structure and function of many neuronal systems in the adult rat brain. The actions of estrogen were thought to be mediated by a single nuclear estrogen receptor (ER) until the recent cloning of a novel ER
P. Shughrue, M. Lane, I. Merchenthaler
semanticscholar +1 more source
Double robust estimation of partially adaptive treatment strategies [PDF]
arXiv, 2021 Precision medicine aims to tailor treatment decisions according to patients' characteristics. G-estimation and dynamic weighted ordinary least squares (dWOLS) are double robust statistical methods that can be used to identify optimal adaptive treatment strategies.
arxiv
Generation and reproductive phenotypes of mice lacking estrogen receptor beta.
Proceedings of the National Academy of Sciences of the United States of America, 1998 Estrogens influence the differentiation and maintenance of reproductive tissues and affect lipid metabolism and bone remodeling. Two estrogen receptors (ERs) have been identified to date, ERalpha and ERbeta.
J. Krege +9 more
semanticscholar +1 more source
Approximate calculation of the binding energy between 17$β$-estradiol and human estrogen receptor alpha [PDF]
arXiv, 2019 Estrogen receptors (ERs) are a group of proteins activated by 17$\beta$-estradiol. The endocrine-disrupting chemicals (EDCs) mimic estrogen action by bind directly to the ligand binding domain of ER. From this perspective, ER represent a good model for identifying and assessing the health risk of potential EDCs.
arxiv
LIMO: Latent Inceptionism for Targeted Molecule Generation [PDF]
arXiv, 2022 Generation of drug-like molecules with high binding affinity to target proteins remains a difficult and resource-intensive task in drug discovery. Existing approaches primarily employ reinforcement learning, Markov sampling, or deep generative models guided by Gaussian processes, which can be prohibitively slow when generating molecules with high ...
arxiv
Exploring The Contribution of Innate Immune Cells to Breast Cancer Immunotherapy [PDF]
arXiv, 2023 Breast cancer is the leading type of cancer in women. About 10-15% of breast cancers are triple-negative breast cancer (TNBC), a subtype with the worst prognosis. Due to the lack of estrogen, progesterone and HER2 receptor expression, chemotherapies have been the standard of care for decades.
arxiv
Oncology Report, 2014 Anti-estrogens such as tamoxifen are widely used in the clinic to treat estrogen receptor-positive breast tumors. Patients with estrogen receptor-positive breast cancer initially respond to treatment with anti-hormonal agents such as tamoxifen, but ...
Rubí Viedma-Rodríguez +7 more
semanticscholar +1 more source
Molecular Endocrinology, 2000 Estrogen rapidly activates the mitogen-activated protein kinases, Erk-1 and Erk-2, via an as yet unknown mechanism. Here, evidence is provided that estrogen-induced Erk-1/-2 activation occurs independently of known estrogen receptors, but requires the ...
E. Filardo +4 more
semanticscholar +1 more source