Results 41 to 50 of about 2,368,340 (74)
Computational Estimates of Binding Affinities for Estrogen Receptor Isoforms in Rainbow Trout [PDF]
arXiv, 2009 Molecular dynamics simulations were used to determine the binding affinities between between the hormone 17 beta-estradiol (E2) and different estrogen receptor (ER) isoforms in the rainbow trout, Oncorhynchus mykiss. Previous phylogenetic analysis indicates that a whole genome duplication prior to the divergence of ray-finned fish led to two distinct ...
arxiv
Molecular Endocrinology, 2005 Estrogen receptors (ERs) act by regulating transcriptional processes. The classical mechanism of ER action involves estrogen binding to receptors in the nucleus, after which the receptors dimerize and bind to specific response elements known as estrogen ...
L. Björnström, M. Sjöberg
semanticscholar +1 more source
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.
Endocrinology, 2005 Although nonclassical estrogen actions initiated at the cell surface have been described in many tissues, the identities of the membrane estrogen receptors (mERs) mediating these actions remain unclear.
P. Thomas +3 more
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Exploiting synthetic lethal vulnerabilities for cancer therapy [PDF]
arXiv, 2016 Synthetic lethality refers to a combination of two or more genetic events (typically affecting different genes) in which the co-occurrence of the events results in cell or organismal lethality, but the cell or organism remains viable when only one of the events occurs.
arxiv
Enhancer transcripts mark active estrogen receptor binding sites
Genome Research, 2013 We have integrated and analyzed a large number of data sets from a variety of genomic assays using a novel computational pipeline to provide a global view of estrogen receptor 1 (ESR1; a.k.a. ERα) enhancers in MCF-7 human breast cancer cells.
N. Hah +4 more
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Analysis of differential splicing suggests different modes of short-term splicing regulation [PDF]
arXiv, 2016 Motivation: Alternative splicing is an important mechanism in which the regions of pre-mRNAs are differentially joined in order to form different transcript isoforms. Alternative splicing is involved in the regulation of normal physiological functions but also linked to the development of diseases such as cancer.
arxiv
Journal of the National Cancer Institute, 2004 BACKGROUND Patients receiving adjuvant tamoxifen whose tumors express high levels of both HER2/neu (HER2) and the estrogen receptor (ER) coactivator AIB1 often develop tamoxifen resistance.
J. Shou +6 more
semanticscholar +1 more source
Modeling, Simulating, and Parameter Fitting of Biochemical Kinetic Experiments [PDF]
arXiv, 2015 In many chemical and biological applications, systems of differential equations containing unknown parameters are used to explain empirical observations and experimental data. The DEs are typically nonlinear and difficult to analyze, requiring numerical methods to approximate the solutions.
arxiv
FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection
Science Translational Medicine, 2013 Clomiphene and toremifene inhibit Ebola virus infection. Fertile Strategy for Ebola Infection Perhaps no virus has grasped the public’s imagination like Ebola virus.
L. Johansen +13 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2013 Male reproductive function is under the control of both gonadotropins and androgens through a negative feedback loop that involves the hypothalamus, pituitary, and testis known as hypothalamus–pituitary–gonadal axis (HPG).
A. Chimento +3 more
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