Results 241 to 250 of about 2,243,537 (271)

JAK2 Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?

Movement Disorders Clinical Practice, EarlyView.
Abstract Background JAK2 variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well‐recognized neurological occurrence in this context ...
Elena Ardila Jurado, Koustubh Bavdhankar, Divyani Garg, Francesca Magrinelli, Huw R. Morris, Kailash P. Bhatia   +5 more
wiley   +1 more source

Aptamer Proteolysis-Targeting Chimeras (PROTACs): A Novel Strategy to Combat Drug Resistance in Estrogen Receptor α-Positive Breast Cancer. [PDF]

ACS Pharmacol Transl Sci
Feng Y, Zhang Z, Zhang H, Guo H, Tan C, Xu N, Tan Y, Jiang Y.   +7 more
europepmc   +1 more source

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu. [PDF]

Proc Natl Acad Sci U S A
Min CK, Nwachukwu JC, Hou Y, Russo RJ, Papa A, Min J, Peng R, Kim SH, Ziegler Y, Rangarajan ES, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW.   +13 more
europepmc   +1 more source

An estrogen receptor α-derived peptide improves glucose homeostasis during obesity. [PDF]

Nat Commun
Yang W, Jiang W, Liao W, Yan H, Ai W, Pan Q, Brashear WA, Xu Y, He L, Guo S.   +9 more
europepmc   +1 more source

LINC00173 silence and estrone supply suppress ER⁺ breast cancer by estrogen receptor α degradation and LITAF activation. [PDF]

Cancer Sci
Xie Y, Shan M, Yu J, Du Y, Wu C, Liu S, Li J, Xiao Y, Yan Y, Li N, Qin J, Lan L, Wang Y.   +12 more
europepmc   +1 more source

Effect of estrogen receptor α on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model.

Am J Physiol Lung Cell Mol Physiol
Severyn NT, Esparza P, Gao H, Mickler EA, Albrecht ME, Fisher AJ, Yakubov B, Cook TG, Slaven JE, Walts AD, Tepper RS, Lahm T.   +11 more
europepmc   +1 more source

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Comparison of transcriptional synergy of estrogen receptors α and β from multiple tandem estrogen response elements

Molecular and Cellular Endocrinology, 2000
Estrogen receptors alpha and beta (ERalpha and ERbeta) act as ligand-dependent transcriptional enhancers. We reported that ERalpha induces synergistic activation of luciferase reporter gene activity in response to E(2) from three or four tandem copies of a consensus estrogen response element (ERE) in transiently transfected MCF-7 cells.
V V, Tyulmenkov, S C, Jernigan, C M, Klinge   +2 more
openaire   +2 more sources

Absence of estrogen receptor-β expression in metastatic ovarian cancer

Obstetrics & Gynecology, 2000
To evaluate the expression of estrogen receptor (ER)alpha and ERbeta mRNA and protein in normal ovarian tissue and primary and metastatic tumors.Estrogen receptor alpha and ERbeta expression was studied in normal ovarian biopsies (n = 9) and primary (n = 8) and metastatic ovarian epithelial cancers (n = 8).
T, Rutherford, W D, Brown, E, Sapi, S, Aschkenazi, A, Muñoz, G, Mor   +5 more
openaire   +2 more sources

Rapid actions of estrogens in GH3/B6 pituitary tumor cells via a plasma membrane version of estrogen receptor-α

Steroids, 1999
The focus of our work on rapid actions of estrogens has been on the immuno-identification of a membrane version of the estrogen receptor-alpha (mERalpha) and the correlation of the presence of this receptor to the rapid secretion of prolactin in pituitary tumor cells. We demonstrated the mERalpha by both fluorescence and immuno-enzyme-cytochemistry and
C S, Watson, A M, Norfleet, T C, Pappas, B, Gametchu   +3 more
openaire   +2 more sources