Results 81 to 90 of about 306,344 (322)

A framework for safe estradiol modulation in male bipolar disorder: theoretical justification for SERM-enabled adjunctive therapy

Frontiers in Psychiatry
Treatment-resistant bipolar disorder (TR-BD) in males remains a significant clinical challenge, often unresponsive to standard monoaminergic therapies.
John Carlson
doaj   +1 more source

Neuroprotective Effects of Genistein in Mongolian Gerbils: Estrogen Receptor–β Involvement

Journal of Pharmacological Sciences, 2010
Genistein is a naturally occurring plant-derived phytoestrogen, present in the human diet, known to possess some beneficial effects. The present study investigated the effect of genistein on neuroprotection evaluated through electroencephalographic and ...
Andrea Donzelli, Daniela Braida, Annamaria Finardi, Valeria Capurro, Anna Elisa Valsecchi, Mariapia Colleoni, Mariaelvina Sala   +6 more
doaj   +1 more source

Uji In Silico Senyawa 2,6-dihidroksiantraquinon sebagai Ligan pada Reseptor Estrogen Alfa [PDF]

, 2015
Previous studies has shown that estrogen receptor alpha that binds to estrogen may increase cancer cell proliferation, thus estrogen receptor alpha can be targeted to cure breast cancer.
Setiawan, F. F. (Felicia), Istyastono, E. P. (Enade)   +1 more
core   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

A case-matched comparison of ER-α and ER-β expression between malignant and benign cystic pancreatic lesions

Oncologie
Older studies failed to establish a link between estrogen receptor (ER) expression and pancreatic adenocarcinoma, with findings either statistically insignificant or contradictory. The recent discovery of two distinct isoforms, namely ER-α and ER-β, with
Lykoudis Panagis M., Papaconstantinou Ioannis, Dafnios Nikolaos, Charalampous Charalampos M., Konti Charis, Vlachodimitropoulos Dimitrios, Contis John   +6 more
doaj   +1 more source

The Role of GLI-1 in Endocrine Resistant Breast Cancer [PDF]

, 2014
Estrogen receptor positive (ER+) and estrogen receptor negative (ER-) are two major types of breast cancer. For women with ER+ positive breast cancer, patients are treated with the antiestrogenic compounds, tamoxifen or faslodex for five years ...
Rudolph, Mark
core  

3D model of amphioxus steroid receptor complexed with estradiol [PDF]

, 2009
The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates.
David J. Chang, Michael E. Baker
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Maximizing Production of Estrogen Receptor β with the Baculovirus Expression System

BioTechniques, 2003
Steroid hormone/nuclear receptor expression in cultured insect cell lines is routinely driven by a baculovirus vector. An advantage of the baculovirus production of these receptors is that large amounts of functional receptors are obtained for subsequent
Peter C. Kulakosky, Carolyn M. Klinge
doaj   +1 more source