Results 271 to 280 of about 82,886 (305)

Estrogen Receptors alpha and beeta Two Receptors of a Kind

Current Medicinal Chemistry, 2000
Ever since the discovery of estradiol and the elucidation of its chemical structure, there has been a great deal of interest in its mechanism of action and its potential therapeutic value. It is now well established that estrogens have many different functions in many different cell-types.
K, Dechering, C, Boersma, S, Mosselman
openaire   +2 more sources

Different cell activities in breast cancer based on different estrogen receptor-alpha(+)/estrogen receptor-alpha(-) ratios.

Journal of Clinical Oncology, 2016
e12004Background: Estrogen receptor-alpha (ERα) is implicated in breast cancer progression. Although tamoxifen and aromatase inhibitors have been widely used to treat ERα-positive breast cancer, th...
Yanchu Li, Zhang Hengli, Gou Qiheng, Zhang Jiahui, Ping Li   +4 more
openaire   +1 more source

The mouse estrogen receptor-related orphan receptor alpha 1: molecular cloning and estrogen responsiveness

Journal of Molecular Endocrinology, 1997
Estrogen receptor-related orphan receptor alpha 1 is a member of the steroid/thyroid nuclear receptor superfamily. We have previously cloned the human estrogen receptor-related orphan receptor alpha 1 (hERR alpha 1) cDNA and demonstrated that it enhances estrogen responsiveness of the lactoferrin gene promoter in transfected human endometrial carcinoma
H, Shigeta, W, Zuo, N, Yang, R, DiAugustine, C T, Teng   +4 more
openaire   +2 more sources

Polymorphisms of estrogen receptor alpha in prostate cancer

Molecular Carcinogenesis, 2003
AbstractEstrogen receptor (ER) α polymorphisms have been shown to be involved in the oncogenesis of several organs. We hypothesize that polymorphisms of the ERα gene are risk factors for prostate cancer. The genotypic distributions of six different loci (codons: 10 T → C, 87 G → C, 243 C → T, 325 C → G, 594 G → A, and intron 1 C → T) of the ERα gene ...
Yuichiro, Tanaka, Masahiro, Sasaki, Masanori, Kaneuchi, Hiroaki, Shiina, Mikio, Igawa, Rajvir, Dahiya   +5 more
openaire   +2 more sources

Estrogen receptor alpha negative breast cancer patients: Estrogen receptor beta as a therapeutic target

The Journal of Steroid Biochemistry and Molecular Biology, 2008
Clinical management of breast cancer is increasingly guided by assessment of tumor phenotypic parameters. One of these is estrogen receptor (ER) status, currently defined by ERalpha expression. However with the discovery of a second ER, ERbeta and its variant isoforms, the definition of ER status is potentially more complex.
George P, Skliris, Etienne, Leygue, Peter H, Watson, Leigh C, Murphy   +3 more
openaire   +2 more sources

Estrogen Receptor Alpha mRNA in Human Skeletal Muscles

Medicine & Science in Sports & Exercise, 2003
To explain the effect of estrogen on skeletal muscle, the presence of estrogen receptor alpha mRNA (ERalpha mRNA) was investigated in human skeletal muscle.The highly sensitive technique of nested reverse transcriptase-polymerase chain reaction (nested RT-PCR) was applied on a variety of tissue samples of both sexes: women (deltoid, pectoral, and ...
Sophie, Lemoine, Pascale, Granier, Christophe, Tiffoche, Francoise, Rannou-Bekono, Marie-Lise, Thieulant, Paul, Delamarche   +5 more
openaire   +2 more sources

Nutritional flavonoids modulate estrogen receptor alpha signaling.

IUBMB life, 2004
Estrogen receptor alpha (ERalpha) mediates 17beta-estradiol (E2) actions through the transcription of E2-sensitive target genes. In addition, rapid non-genomic signaling (e.g., MAPK/ERK) occurs. It is now well accepted that these rapid membrane-initiated responses account for E2-related cancer.
Virgili F, ACCONCIA, FILIPPO, Ambra R, Rinna A, TOTTA, PIERANGELA, MARINO, Maria   +5 more
openaire   +4 more sources

Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium

Acta Histochemica, 2004
The endometrium expresses estrogen (ER) and progesterone receptors (PR), which are involved in autocrine and paracrine regulation processes in response to estrogen and progesterone. The aim of the present study was to evaluate immunohistochemical distribution patterns of estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta) and PR in ...
Ioannis, Mylonas, Udo, Jeschke, Naim, Shabani, Christina, Kuhn, Angelika, Balle, Silke, Kriegel, M S Markus S, Kupka, Klaus, Friese   +7 more
openaire   +2 more sources

P1-05-02: Epigenetic Regulation by Alcohol Reactivates Estrogen Receptor alpha in Estrogen Receptor alpha-Negative Cells.

Cancer Research, 2011
Abstract Introduction: Alcohol consumption is an established risk factor for breast cancer development and contributes to mammary tumorigenesis through the regulation of estrogen receptor alpha (ERα) expression. Previously, we reported that alcohol consumption in the MMTV-neu ERα-negative mouse model of human breast cancer resulted in ...
AW Wong, N Nunez
openaire   +1 more source

Binding studies on estrogen receptor alpha

2009
Die wachsende Anzahl an charakterisierten molekularen Rezeptoren liefert die Basis für das struktur-basierte Design von aktiven Verbindungen zur Entwicklung eines neuen Medikamentes. Ausgehend von einer bekannten oder hypothetischen Wirkungsweise oder einem Bindungsmechanismus wird eine vernünftige Vorlage entworfen, die später experimentell getestet ...
openaire   +1 more source