Results 261 to 270 of about 165,250 (305)
Some of the next articles are maybe not open access.
The multifunctional estrogen receptor-alpha F domain
Endocrine, 2008The members of the nuclear receptor superfamily act as transcriptional regulatory factors and exhibit a multidomain structure characterized as domains A-E/F. This review focuses on a small, relatively understudied region at the extreme carboxy-terminus of the estrogen receptor (ER) alpha, the F domain.
Debra F, Skafar, Changqing, Zhao
openaire +2 more sources
Photoperiod affects estrogen receptor alpha, estrogen receptor beta and aggressive behavior.
The European journal of neuroscience, 2007Estrogens have important effects on male and female social behavior. Despite growing knowledge of the anatomy and behavioral effects of the two predominant estrogen receptor subtypes in mammals (ERalpha and ERbeta), relatively little is known about how these receptors respond to salient environmental stimuli. Many seasonally breeding species respond to
Brian C, Trainor +2 more
openaire +2 more sources
Estrogen and hypoxia regulate estrogen receptor alpha in a synergistic manner
Biochemical and Biophysical Research Communications, 2009Hypoxia activates and degrades estrogen receptor alpha (ERalpha) in human breast cancer cells, which may play an important role in the development and progression of breast cancer. In this study, the synergistic effects of estrogen (E(2)) and hypoxia on ERalpha-mediated transactivation and ERalpha degradation were investigated.
Jinhyung Michael, Yi +3 more
openaire +2 more sources
p33ING1b and estrogen receptor (ER) α
Breast Cancer, 2004The ING1 gene was originally cloned as a candidate tumor suppressor of human breast cancer, and recent studies suggest that ING1 proteins are involved in chromatin remodeling functions via physical association with both histone acetyltransferases (HATs) and histone deacetylases (HDACs). Both CREB binding protein (CBP) and the related p300 proteins show
Tatsuya, Toyama, Hirotaka, Iwase
openaire +2 more sources
Estrogen receptors alpha mediates postischemic inflammation in chronically estrogen-deprived mice
Neurobiology of Aging, 2016Estrogens are known to exert neuroprotective and immuneomodulatory effects after stroke. However, at present, little is known about the role of estrogens and its receptors in postischemic inflammation after menopause. Here, we provide important in vivo evidence of a distinct shift in microglial phenotypes in the model of postmenopause brain.
Pierre, Cordeau +3 more
openaire +2 more sources
S-palmitoylation modulates human estrogen receptor-α functions
Biochemical and Biophysical Research Communications, 200417beta-Estradiol (E2)-induced rapid functions (from seconds to minutes) can be attributed to a fraction of nuclear estrogen receptor-alpha (ERalpha) localized at the plasma membrane. As a potential mechanism, we postulated that S-palmitoylation of the Cys447 residue may explain the ability of ERalpha to associate to plasma membrane making possible E2 ...
ACCONCIA, FILIPPO +4 more
openaire +4 more sources
Estrogen Receptors alpha and beeta Two Receptors of a Kind
Current Medicinal Chemistry, 2000Ever since the discovery of estradiol and the elucidation of its chemical structure, there has been a great deal of interest in its mechanism of action and its potential therapeutic value. It is now well established that estrogens have many different functions in many different cell-types.
K, Dechering, C, Boersma, S, Mosselman
openaire +2 more sources
Journal of Clinical Oncology, 2016
e12004Background: Estrogen receptor-alpha (ERα) is implicated in breast cancer progression. Although tamoxifen and aromatase inhibitors have been widely used to treat ERα-positive breast cancer, th...
Yanchu Li +4 more
openaire +1 more source
e12004Background: Estrogen receptor-alpha (ERα) is implicated in breast cancer progression. Although tamoxifen and aromatase inhibitors have been widely used to treat ERα-positive breast cancer, th...
Yanchu Li +4 more
openaire +1 more source
Journal of Molecular Endocrinology, 1997
Estrogen receptor-related orphan receptor alpha 1 is a member of the steroid/thyroid nuclear receptor superfamily. We have previously cloned the human estrogen receptor-related orphan receptor alpha 1 (hERR alpha 1) cDNA and demonstrated that it enhances estrogen responsiveness of the lactoferrin gene promoter in transfected human endometrial carcinoma
H, Shigeta +4 more
openaire +2 more sources
Estrogen receptor-related orphan receptor alpha 1 is a member of the steroid/thyroid nuclear receptor superfamily. We have previously cloned the human estrogen receptor-related orphan receptor alpha 1 (hERR alpha 1) cDNA and demonstrated that it enhances estrogen responsiveness of the lactoferrin gene promoter in transfected human endometrial carcinoma
H, Shigeta +4 more
openaire +2 more sources
Polymorphisms of estrogen receptor alpha in prostate cancer
Molecular Carcinogenesis, 2003AbstractEstrogen receptor (ER) α polymorphisms have been shown to be involved in the oncogenesis of several organs. We hypothesize that polymorphisms of the ERα gene are risk factors for prostate cancer. The genotypic distributions of six different loci (codons: 10 T → C, 87 G → C, 243 C → T, 325 C → G, 594 G → A, and intron 1 C → T) of the ERα gene ...
Yuichiro, Tanaka +5 more
openaire +2 more sources