Results 261 to 270 of about 90,675 (307)

Estrogen and hypoxia regulate estrogen receptor alpha in a synergistic manner

Biochemical and Biophysical Research Communications, 2009
Hypoxia activates and degrades estrogen receptor alpha (ERalpha) in human breast cancer cells, which may play an important role in the development and progression of breast cancer. In this study, the synergistic effects of estrogen (E(2)) and hypoxia on ERalpha-mediated transactivation and ERalpha degradation were investigated.
Youngjoo Lee
exaly   +3 more sources

Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium

Acta Histochemica, 2004
The endometrium expresses estrogen (ER) and progesterone receptors (PR), which are involved in autocrine and paracrine regulation processes in response to estrogen and progesterone. The aim of the present study was to evaluate immunohistochemical distribution patterns of estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta) and PR in ...
Ioannis Mylonas, Udo Jeschke, Naim Shabani   +2 more
exaly   +3 more sources

Transcriptional Suppression of the Estrogen Receptor by Truncated Estrogen Receptor-Alpha

Hormone and Metabolic Research, 2002
The estrogen receptor (ER) is composed of six major functional domains - the A/B domain as the activation function 1 domain, domain C as the DNA-binding domain, domain D as a hinge domain, and domain E/F as the ligand-dependent transcriptional domains. A novel protein (designated as SRB-RGS) that interacted with domains C and D of ER alpha (ER alpha C ...
M, Ikeda, M, Okai, T, Miyoshi, S, Tone, Y, Minatogawa   +4 more
openaire   +2 more sources

Estrogen Receptors alpha and beeta Two Receptors of a Kind

Current Medicinal Chemistry, 2000
Ever since the discovery of estradiol and the elucidation of its chemical structure, there has been a great deal of interest in its mechanism of action and its potential therapeutic value. It is now well established that estrogens have many different functions in many different cell-types.
K, Dechering, C, Boersma, S, Mosselman
openaire   +2 more sources

Estrogen receptor α is essential for induction of oxytocin receptor by estrogen

NeuroReport, 1998
The induction of oxytocin receptor (OTR) synthesis in the periphery and in the brain by estrogen is critical for reproductive success. Oxytocin receptors are involved in the control of parturition, milk ejection, and sexual and maternal behaviors.
L J, Young, Z, Wang, R, Donaldson, E F, Rissman   +3 more
openaire   +2 more sources

Estrogen receptor alpha and beta in health and disease

Best Practice & Research Clinical Endocrinology & Metabolism, 2015
Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation, and osteoporosis.
Jia M, Dahlman-Wright K, Gustafsson JÅ
openaire   +3 more sources

Polymorphisms of estrogen receptor alpha in prostate cancer

Molecular Carcinogenesis, 2003
AbstractEstrogen receptor (ER) α polymorphisms have been shown to be involved in the oncogenesis of several organs. We hypothesize that polymorphisms of the ERα gene are risk factors for prostate cancer. The genotypic distributions of six different loci (codons: 10 T → C, 87 G → C, 243 C → T, 325 C → G, 594 G → A, and intron 1 C → T) of the ERα gene ...
Yuichiro, Tanaka, Masahiro, Sasaki, Masanori, Kaneuchi, Hiroaki, Shiina, Mikio, Igawa, Rajvir, Dahiya   +5 more
openaire   +2 more sources

The multifunctional estrogen receptor-alpha F domain

Endocrine, 2008
The members of the nuclear receptor superfamily act as transcriptional regulatory factors and exhibit a multidomain structure characterized as domains A-E/F. This review focuses on a small, relatively understudied region at the extreme carboxy-terminus of the estrogen receptor (ER) alpha, the F domain.
Debra F, Skafar, Changqing, Zhao
openaire   +2 more sources

An estrogen receptor ?-dependent regulation of estrogen receptor?related receptor ? in the proliferation of endometrial carcinoma cells

International Journal of Gynecological Cancer, 2006
Estrogen receptor-related receptor alpha (ERRalpha) was reported to compete with estrogen receptor alpha (ERalpha) in a constitutive manner as an orphan nuclear closely related to (ERalpha). To discuss the role of ERRalpha in the endometrial carcinoma cells, this study was performed. ER-responsive endometrial carcinoma cells Ishikawa and ER-nonresponse
P-M, Sun, M, Gao, L-H, Wei, A, Mustea, J-L, Wang, D, Könsgen, W, Lichtenegger, J, Sehouli   +7 more
openaire   +2 more sources

Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen receptor alpha-mediated cell proliferation

Urologic Oncology: Seminars and Original Investigations, 2020
Estrogen-like metabolites have been identified in S. haematobium, the helminth parasite that causes urogenital schistosomiasis (UGS) and in patients´ blood and urine during UGS. Estrogen receptor (ER) activation is enriched in the luminal molecular subtype bladder cancer (BlaCa). To date, the significance of ER to these diseases remains elusive.
Bernardo, Carina, Santos, Júlio, Costa, Céu, Tavares, Ana, Amaro, Teresina, Marques, Igor, Gouveia, Maria João, Félix, Vítor, Afreixo, Vera, Brindley, Paul J., Costa, José Manuel, Amado, Francisco, Helguero, Luisa, Santos, Lúcio L.   +13 more
openaire   +3 more sources