Results 241 to 250 of about 165,250 (305)

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design

Verhoef CJA, Crowe C, Nakasone MA, DeLaCuadra-Basté A, Harzing T, Span NAS, Sathe G, Iso K, Ottmann C, Brunsveld L, Ciulli A, Cossar PJ.   +11 more
europepmc   +1 more source

Salivary gland protective and antiinflammatory effects of genistein in Sjögren's syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha. [PDF]

Cell Mol Biol Lett
Mao T, Wei W, Chen B, Chen Y, Liang S, Chen G, Liu Z, Wu X, Wu L, Li X, Watanabe N, Mayo KH, Pathak JL, Li J.   +13 more
europepmc   +1 more source

Epigenetic Regulation of Immune Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome

The Prostate, EarlyView.
ABSTRACT Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating condition with unclear etiology. Increasing evidence implicates immune dysregulation, yet the molecular mechanisms underlying impaired immune regulation remain poorly defined. This study investigated the role of altered immune responses within
Praveen Thumbikat, Goutham Pattabiraman, Farzaneh Sharifzad, Yongyong Yang, Zhiqiang Liu, Catherine V. Osborn, Stephen F. Murphy, Qi Cao, Anthony J. Schaeffer   +8 more
wiley   +1 more source

LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer. [PDF]

Cell Death Dis
Melone V, Palumbo D, Palo L, Brusco N, Salvati A, Tarallo A, Giurato G, Rizzo F, Nassa G, Weisz A, Tarallo R.   +10 more
europepmc   +1 more source

Trends and Patterns for the Use of Herbal Medicinal Products for Gynaecological Ailments

Phytotherapy Research, EarlyView.
ABSTRACT Most Germans consider herbal medicinal products (HMPs) to be an important supplement to conventional medicine. Despite existing clinical evidence for safety and efficacy, they are still not sufficiently integrated into drug therapy of gynaecological complaints in everyday practice.
Alexandra Drebka, Annika J. Scholl, Teresa Ochs, Olaf Kelber, Ralph Mösges, Beatrice E. Bachmeier   +5 more
wiley   +1 more source

RNA fine-tunes estrogen receptor-alpha binding on low-affinity DNA motifs for transcriptional regulation. [PDF]

EMBO J
Soota D, Saravanan B, Mann R, Kharbanda T, Notani D.   +4 more
europepmc   +1 more source

GatorST: A Versatile Contrastive Meta‐Learning Framework for Spatial Transcriptomic Data Analysis

Small Methods, EarlyView.
GatorST learns spatially informed embeddings for spatial transcriptomics by coupling two‐hop subgraph graph convolutions with cluster‐aware pseudo‐label supervision and episodic contrastive meta‐learning. The framework captures neighbor‐level topology and tissue‐wide expression semantics without heavy augmentations, delivering robust representations ...
Zhenhao Zhang, Yuxi Liu, Song Wang, Qin Ma, Qianqian Song, Jiang Bian   +5 more
wiley   +1 more source

Association of Inflammation and Immune Cell Infiltration with Estrogen Receptor Alpha in an Estrogen and Ionizing Radiation-Induced Breast Cancer Model. [PDF]

Int J Mol Sci
Koning T, Calaf GM.
europepmc   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source