Results 221 to 230 of about 87,687 (260)

Regulation of Metabolism by Estrogen Receptor Alpha

The FASEB Journal, 2016
Postmenopausal estrogen deficiency increases the risk for metabolic syndrome, obesity, and type 2 diabetes. Estrogen treatment improves metabolic function in postmenopausal women, and estrogen receptor α (ERα) is thought to be the primary player in these protective metabolic effects.
Ashley E. Archer, Robert S. Rogers, Joshua L. Wheatley, Kathleen White, M.A. Karim Rumi, Michael J. Soares, Paige C. Geiger   +6 more
openaire   +1 more source

Glycosylation of the murine estrogen receptor-α

The Journal of Steroid Biochemistry and Molecular Biology, 2000
O-linked N-acetylglucosamine (O-GlcNAc) is a highly dynamic and abundant modification found on nuclear and cytoplasmic proteins of nearly all eukaryotes. O-GlcNAc addition is required for life at the single cell level and is analogous to protein phosphorylation in most respects. In a previous study (M.S. Jiang, G.W.
X, Cheng, G W, Hart
openaire   +2 more sources

p33ING1b and estrogen receptor (ER) α

Breast Cancer, 2004
The ING1 gene was originally cloned as a candidate tumor suppressor of human breast cancer, and recent studies suggest that ING1 proteins are involved in chromatin remodeling functions via physical association with both histone acetyltransferases (HATs) and histone deacetylases (HDACs). Both CREB binding protein (CBP) and the related p300 proteins show
Tatsuya, Toyama, Hirotaka, Iwase
openaire   +2 more sources

Role of estrogen receptor-α in pharmacogenetics of estrogen action

Current Opinion in Lipidology, 2003
To summarize recent data regarding the role of estrogen receptor-alpha polymorphisms in determining the response to estrogen therapy or the risk of clinical cardiovascular events.Recent clinical trials of hormone replacement therapy for cardiovascular disease have yielded surprisingly negative results, shifting clinical opinions from a position of ...
openaire   +2 more sources

[Expression of estrogen receptor-related receptor alpha and estrogen receptor alpha in endometrial carcinoma and the primary investigation of their clinical significance].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2008
To explore the roles of estrogen receptor-related receptor (ERR) alpha and estrogen receptor alpha in endometrial carcinoma and their clinical values.Thirty-five cases of endometrial carcinoma were examined by immunohistochemistry. Clinicopathologic features including FIGO stage, histological grade, myometrial invasion and nodal metastasis were ...
Min, Gao, Li-hui, Wei, Peng-ming, Sun, Dan, Zhao, Xiao-ping, Li   +4 more
openaire   +1 more source

LATS2 is a modulator of estrogen receptor alpha.

Anticancer research, 2013
Estrogen Receptor α (ERα), a member of the nuclear receptor superfamily of transcription factors, plays a central role in breast cancer development. More than two-thirds of patients with breast cancer are ERα-positive; however, a proportion becomes resistant.
Lei Cheng, Lit, Susan, Scott, Hua, Zhang, Justin, Stebbing, Andrew, Photiou, Georgios, Giamas   +5 more
openaire   +1 more source

[Estrogen receptor alpha in obesity and diabetes].

Revista medica del Instituto Mexicano del Seguro Social, 2017
Estradiol (E2) is an important hormone in reproductive physiology, cardiovascular, skeletal and in the central nervous system (CNS). In human and rodents, E2 and its receptors are involved in the control of energy and glucose metabolism in health and metabolic diseases.
José Ángel, Cahua-Pablo, Eugenia, Flores-Alfaro, Miguel, Cruz   +2 more
openaire   +1 more source

Systemic therapy for hormone receptor-positive/human epidermal growth factor receptor 2-negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Hope Rugo, Özge Gümüşay, Laura A Huppert   +2 more
exaly  

Binding studies on estrogen receptor alpha

2009
Die wachsende Anzahl an charakterisierten molekularen Rezeptoren liefert die Basis für das struktur-basierte Design von aktiven Verbindungen zur Entwicklung eines neuen Medikamentes. Ausgehend von einer bekannten oder hypothetischen Wirkungsweise oder einem Bindungsmechanismus wird eine vernünftige Vorlage entworfen, die später experimentell getestet ...
openaire   +1 more source

α-Mangostin and its derivatives against estrogen receptor alpha

Journal of Biomolecular Structure and Dynamics, 2022
Maywan Hariono, Richa Mardianingrum, Muchtaridi Muchtaridi   +2 more
exaly