Results 271 to 280 of about 165,250 (305)
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The Journal of Steroid Biochemistry and Molecular Biology, 2008
Clinical management of breast cancer is increasingly guided by assessment of tumor phenotypic parameters. One of these is estrogen receptor (ER) status, currently defined by ERalpha expression. However with the discovery of a second ER, ERbeta and its variant isoforms, the definition of ER status is potentially more complex.
George P, Skliris +3 more
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Clinical management of breast cancer is increasingly guided by assessment of tumor phenotypic parameters. One of these is estrogen receptor (ER) status, currently defined by ERalpha expression. However with the discovery of a second ER, ERbeta and its variant isoforms, the definition of ER status is potentially more complex.
George P, Skliris +3 more
openaire +2 more sources
Estrogen Receptor Alpha mRNA in Human Skeletal Muscles
Medicine & Science in Sports & Exercise, 2003To explain the effect of estrogen on skeletal muscle, the presence of estrogen receptor alpha mRNA (ERalpha mRNA) was investigated in human skeletal muscle.The highly sensitive technique of nested reverse transcriptase-polymerase chain reaction (nested RT-PCR) was applied on a variety of tissue samples of both sexes: women (deltoid, pectoral, and ...
Sophie, Lemoine +5 more
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Nutritional flavonoids modulate estrogen receptor alpha signaling.
IUBMB life, 2004Estrogen receptor alpha (ERalpha) mediates 17beta-estradiol (E2) actions through the transcription of E2-sensitive target genes. In addition, rapid non-genomic signaling (e.g., MAPK/ERK) occurs. It is now well accepted that these rapid membrane-initiated responses account for E2-related cancer.
Virgili F +5 more
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Acta Histochemica, 2004
The endometrium expresses estrogen (ER) and progesterone receptors (PR), which are involved in autocrine and paracrine regulation processes in response to estrogen and progesterone. The aim of the present study was to evaluate immunohistochemical distribution patterns of estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta) and PR in ...
Ioannis, Mylonas +7 more
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The endometrium expresses estrogen (ER) and progesterone receptors (PR), which are involved in autocrine and paracrine regulation processes in response to estrogen and progesterone. The aim of the present study was to evaluate immunohistochemical distribution patterns of estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta) and PR in ...
Ioannis, Mylonas +7 more
openaire +2 more sources
Cancer Research, 2011
Abstract Introduction: Alcohol consumption is an established risk factor for breast cancer development and contributes to mammary tumorigenesis through the regulation of estrogen receptor alpha (ERα) expression. Previously, we reported that alcohol consumption in the MMTV-neu ERα-negative mouse model of human breast cancer resulted in ...
AW Wong, N Nunez
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Abstract Introduction: Alcohol consumption is an established risk factor for breast cancer development and contributes to mammary tumorigenesis through the regulation of estrogen receptor alpha (ERα) expression. Previously, we reported that alcohol consumption in the MMTV-neu ERα-negative mouse model of human breast cancer resulted in ...
AW Wong, N Nunez
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Binding studies on estrogen receptor alpha
2009Die wachsende Anzahl an charakterisierten molekularen Rezeptoren liefert die Basis für das struktur-basierte Design von aktiven Verbindungen zur Entwicklung eines neuen Medikamentes. Ausgehend von einer bekannten oder hypothetischen Wirkungsweise oder einem Bindungsmechanismus wird eine vernünftige Vorlage entworfen, die später experimentell getestet ...
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Cancer research, 2001
4-Hydroxytamoxifen (4-OHT), a selective estrogen receptor modulator, is an agonist at a transforming growth factor-alpha (TGF-alpha) target gene in situ in MDA-MB-231 human breast cancer cells stably transfected with wild-type human ERalpha. In contrast, raloxifene (Ral) is a complete antiestrogen silencing activation function (AF) 1 and AF2 in this ...
H, Liu +4 more
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4-Hydroxytamoxifen (4-OHT), a selective estrogen receptor modulator, is an agonist at a transforming growth factor-alpha (TGF-alpha) target gene in situ in MDA-MB-231 human breast cancer cells stably transfected with wild-type human ERalpha. In contrast, raloxifene (Ral) is a complete antiestrogen silencing activation function (AF) 1 and AF2 in this ...
H, Liu +4 more
openaire +1 more source
Estrogen receptor-related receptor-alpha (ERR-alpha) is dysregulated in inflammatory arthritis.
Rheumatology (Oxford, England), 2008Subchondral bone loss is a characteristic feature of inflammatory arthritis. Recently, estrogen receptor-related receptor-alpha (ERR-alpha), an orphan nuclear receptor, has been found to be involved in activation of macrophages. We hypothesized that ERR-alpha which is expressed and also functional in articular chondrocytes, osteoblasts and osteoclasts,
E, Bonnelye +4 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
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