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The Role of Estrogen Receptor Beta in Neonatal Oocyte Development
, 2007 Kelsey Breen
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Estrogen receptor beta and neural development
Vitamins and hormones, 2021The female sex hormone estradiol (E2, 17β-estradiol) has important functions in the developing brain. In addition to regulating sexual differentiation of the brain, E2 participates in the development of brain areas involved in functions unrelated to reproduction, such as cognition.
Ivan Nalvarte +4 more
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Estrogen receptor alpha and beta in health and disease
Best Practice & Research Clinical Endocrinology & Metabolism, 2015Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation, and osteoporosis.
Jan-Åke Gustafsson +3 more
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Estrogen Receptor Beta in Cancer: an Attractive Target for Therapy
Current Pharmaceutical Design, 2012While it is well documented that the mitogenic actions of estrogens are critical in the development and progression of human breast and some gynecologic cancers, only latest data demonstrate a crucial involvement of estrogen-signaling in the carcinogenesis of non-classical estrogen target tissues, as colon, prostate, lung, skin, and brain.
Gallo, Daniela +4 more
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Antibody Validation for Estrogen Receptor Beta
2022Antibodies can cross-react with proteins other than their intended targets, and antibody-based applications can, if not properly validated, lead to flawed interpretations. When evaluating 13 anti-estrogen receptor beta (ERβ) antibodies in 2017, we concluded that only one of them was specific.
Madeleine, Birgersson +4 more
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Role of Estrogen Receptor Beta in Estrogen Action
Annual Review of Physiology, 2001▪ Abstract There was a time when the classification of sex hormones was simple. Androgens were male and estrogens female. What remains true today is that in young adults androgen levels are higher in males and estrogen levels higher in females. More recently we have learned that estrogens are necessary in males for regulation of male sexual behavior ...
Katarina Pettersson, Jan-Åke Gustafsson
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Estrogen receptor beta expression correlates with proliferation in desmoid tumors
Journal of Surgical Oncology, 2019Estrogen receptor signaling and cyclin D1 have a major role in tumor cell proliferation in breast cancer. Desmoid tumors are rare neoplasms that may respond to endocrine treatment.
Kirsi Santti +7 more
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Estrogen receptor beta in breast cancer.
Endocrine-related cancer, 2002Estrogen is essential for normal growth and differentiation in the mammary gland. It also supports growth of approximately 50% of primary breast cancers. For this reason, removal of estrogen or blocking of its action with the anti-estrogen, tamoxifen, is the main treatment for estrogen receptor alpha (ERalpha)-positive tumors. In 1996, when oncologists
Margaret Warner +10 more
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Alfa and beta estrogen receptors and the biliary tree
Molecular and Cellular Endocrinology, 2002This manuscript summarizes recent data showing that estrogens and their receptors play an important role in modulating cholangiocyte proliferation. We have recently demonstrated that rat cholangiocytes express both estrogen receptors (ER)-alpha and -beta subtypes, while hepatocytes only express ER-alpha.
ALVARO, Domenico +8 more
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2002
When the discovery of ERβ was reported in 1996 [1], many endocrinologists thought that, since this receptor had gone unnoticed for so long, it must be some sort of vestigial receptor with no function in the endocrinology of estrogen. This idea was quickly dispelled when ERβ-/- mice were created and found to have severely compromised ovarian function ...
Zhang Weihua +5 more
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When the discovery of ERβ was reported in 1996 [1], many endocrinologists thought that, since this receptor had gone unnoticed for so long, it must be some sort of vestigial receptor with no function in the endocrinology of estrogen. This idea was quickly dispelled when ERβ-/- mice were created and found to have severely compromised ovarian function ...
Zhang Weihua +5 more
openaire +2 more sources