Results 211 to 220 of about 150,800 (299)

The novel estrogen receptor beta agonist EGX358 and <i>APOE</i> genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer's mouse model. [PDF]

Front Aging Neurosci
Schwabe MR, Fleischer AW, Kuehn RK, Chaudhury S, York JM, Sem DS, Donaldson WA, LaDu MJ, Frick KM.   +8 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Estrous Cycle-Dependent Modulation of Sexual Receptivity in Female Mice by Estrogen Receptor Beta-Expressing Cells in the Dorsal Raphe Nucleus. [PDF]

J Neurosci
Murakawa T, Kogure L, Hata K, Hasunuma K, Takenawa S, Sano K, Ogawa S.   +6 more
europepmc   +1 more source

Probiotic‐based strategies in vulvovaginal candidiasis management: A comprehensive review of mechanisms and future directions

Interdisciplinary Medicine, EarlyView.
This review focuses on vulvovaginal candidiasis (VVC), examining its epidemiology, the pathogenesis of Candida albicans, and its relationships with vaginal microbiota. It comprehensively reviews probiotic‐based management strategies and their mechanisms of action, and concludes by discussing current limitations, challenges and future research ...
Tong Chen, Yuwei Wu, Ya Chen, Ying Li, Hui Zhao, Lei Wu, He Gao, Tong Jiang, Xiaohong Wang, Moutong Chen, Jumei Zhang, Xinqiang Xie, Tingting Liang, Qingping Wu   +13 more
wiley   +1 more source

Development of the external genitalia. [PDF]

, 2020
Baskin, Laurence S, Cunha, Gerald R
core  

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex- and region-specific manner. [PDF]

Transl Psychiatry
Carter JS, Costa CC, Lewandowski SI, Nelson KH, Goldsmith ST, Scofield MD, Reichel CM.   +6 more
europepmc   +1 more source

Synthesis of an Estrogen Receptor Beta Agonist [PDF]

Synfacts, 2014
openaire   +1 more source

Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini, Francesca Caloni, Paola Fossati, Giancarlo Ruffo, Luciana Rossi   +4 more
wiley   +1 more source

Targeting Estrogen Receptor Beta Ameliorates Diminished Ovarian Reserve via Suppression of the FOXO3a/Autophagy Pathway. [PDF]

Aging Dis
Li F, Zhu J, Liu J, Hu Y, Wu P, Zeng C, Lu R, Wu N, Xue Q.   +8 more
europepmc   +1 more source