Results 111 to 120 of about 163,959 (310)
Advanced Science, EarlyView.This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou +12 more
wiley +1 more source
Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus
Reproductive Biology and Endocrinology, 2009 Background In the mouse uterus, pregnancy is accompanied by changes in tachykinin and tachykinin receptor gene expression and in the uterotonic effects of endogenous tachykinins. In this study we have investigated whether changes in tachykinin expression
Patak Eva +4 more
doaj +1 more source
, 2010 The nuclear hormone receptors, ERα and ERβ, are known to regulate the transcriptional response programs of their target cells, including breast cancer cells.
Charn, Tze Howe
core
, 2022 Knox, DayanPost traumatic stress disorder (PTSD) is a debilitating psychiatric disorder which stems from fear memory persistence after exposure to a traumatic experience. PTSD is associated with a high socioeconomic cost, as well as a higher prevalence
Biddle, Matthew
core +1 more source
Advanced Science, EarlyView.This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley +1 more source
Molecules, 2018 Background: The aim of this study was to explore the estrogenic effects of the extracts from Chinese yam and its effective compounds. Methods: The activity of the yam was investigated by the uterine weight gain of mice and a proliferation assay of breast
Mengnan Zeng +7 more
doaj +1 more source
, 2016 Introduction : The hormone leptin, which is produced in the adipose tissue, may influence tumorigenesis directly via its receptor (Ob-R). Thus, a role for Ob-R in endometrial carcinogenesis has been proposed.
Luis Fernando Méndez-López +4 more
core +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Alfa and beta estrogen receptors and the biliary tree
, 2002 This manuscript summarizes recent data showing that estrogens and their receptors play an important role in modulating cholangiocyte proliferation. We have recently demonstrated that rat cholangiocytes express both estrogen receptors (ER)-alpha and -beta
ALVARO, Domenico +8 more
core +2 more sources
Estrogen and Progesterone Receptors in the Endometrium
Annals of the New York Academy of Sciences, 1997 The endometrium, as a target of estrogens and progestins, possesses the respective receptor proteins. These receptors belong to the superfamily of nuclear receptors, having important functional domains required for steroid ligand binding, for dimer formation, for interaction with HREs of DNA, for transcription modulation, for association with other ...
Moutsatsou, P., Sekeris, C.E.
openaire +4 more sources