Results 121 to 130 of about 163,959 (310)

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals

, 1999
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens,
Andersson, AM, McLachlan, J, Steven F. Arnold, Arnold, SF, Philippe Grandjean, Andersen, HR, John P. Sumpter, Autrup, H, Henrik Leffers, Eva Bonefeld Jørgensen, Leffers, H, Ana M. Soto, Moller, A, Hummel, R, Oles-Karasko, A, Susan M. Thorpe, Beresford, NA, Perez, P, Thorpe, SM, Marianne Barfoed, Remy Le Guevel, Anette Møller, Nielsen, JB, Pakdel, F, Knud L. Pedersen, Pilar Perez, Christiansen, LB, Herman Autrup, Anita Oles-Karasko, Nicola A. Beresford, John McLachlan, Nicolas Olea, Skakkeboek, NE, Birgitte Gissel, Pedersen, KL, Korsgaard, B, Le Guevel, R, Grandjean, P, Lisette B. Christiansen, Bodil Korsgaard, Carlos Sonnenschein, Barfoed, M, Barfoed, N, Farzad Pakdel, René Hummel, Helle Raun Andersen, Gissel, B, Poul Bjerregaard, Bjerregaard, P, Soto, AM, Niels Erik Skakkebœk, Olea, N, Sumpter, JP, Anna-Maria Andersson, Jesper Bo Nielsen, Jorgensen, EB, Sonnenschein, C   +56 more
core   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

eLife, 2016
The association between pregnancy and altered cutaneous pigmentation has been documented for over two millennia, suggesting that sex hormones play a role in regulating epidermal melanocyte (MC) homeostasis.
Christopher A Natale, Elizabeth K Duperret, Junqian Zhang, Rochelle Sadeghi, Ankit Dahal, Kevin Tyler O'Brien, Rosa Cookson, Jeffrey D Winkler, Todd W Ridky   +8 more
doaj   +1 more source

Estrogen receptor co-regulators as prognostic and predictive markers of endocrine therapy in early breast cancer: the role of SMRT and p160 family

, 2010
Background: The estrogen receptor (ER) signaling pathway is the dominant driver of cell proliferation and survival in the majority of human breast cancers.
Migliaccio, Ilenia
core  

Estrogen-Induced Apoptosis of Breast Epithelial Cells Is Blocked by NO/cGMP and Mediated by Extranuclear Estrogen Receptors

, 2010
Estrogen action, via both nuclear and extranuclear estrogen receptors (ERs), induces a variety of cellular signals that are prosurvival or proliferative, whereas nitric oxide (NO) can inhibit apoptosis via caspase S-nitrosylation and via activation of ...
Gregory R. J. Thatcher, Praneeth D. Edirisinghe, Praneeth D. Edirisinghe (194640), Gihani T. Wijewickrama (1926958), Irida Kastrati, Gregory R. J. Thatcher (7942685), Gihani T. Wijewickrama, Irida Kastrati (194639)   +7 more
core   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues

Current Issues in Molecular Biology
Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1).
Ju Rong, Xiaojun Xie, Yongdong Niu, Zhongjing Su   +3 more
doaj   +1 more source

Mechanisms governing the protective effect of 17b-estradiol and estrogen receptors against cardiomyocyte injury

, 2012
[[abstract]]The sex hormone 17b-estradiol (E2) is the most abundant and active estrogen in premenopausal women. Studies have shown that high circulating levels of E2 are cardioprotective and are associated with reduced risk of developing heart disease in
黃志揚;HUANG, CHIH-YANG
core  

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source