The binding of estrogen and estrogen antagonists to the estrogen receptor
The model of the estrogen receptor as a dimer of identical, interacting subunits and data obtained by Sasson and Notides (1988, Mol. Endocrinol. 2, 307-312) were used to find the standard free energy changes that describe the binding of estradiol and 4-hydroxytamoxifen to the estrogen receptor.
J P, Bond, S, Sasson, A C, Notides
openaire +2 more sources
Estrogen-Receptor Expression and Function in Female Reproductive Disease
Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ...
Zi-Run Tang +4 more
doaj +1 more source
Immunoekspresi Reseptor α pada Poket Periodontal Lebih Banyak daripada Reseptor Estrogen β
Studies have been reported on the association between menopause and periodontal disease related to estrogen deficiency. Although the estrogen receptor has been demonstrated on some oral tissues, the presence of estrogen receptors on periodontal pockets ...
Yuliana Mahdiyah Da’at Arina
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Sex differences in the nervous system have gained recent academic interest. While the prominent differences are observed in mood and anxiety disorders, growing number of evidences also suggest sex difference in pain perception.
Seon-Hong Seol, Gehoon Chung
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Endometrial Progesterone and Estrogen Receptors in Relation to Hormonal Levels in Women with Unexplained Recurrent Miscarriage [PDF]
Objective Recurrent miscarriage has been linked to hormonal disturbance due to dysregulation of its receptors rather than to the availability of the hormone.
Ihab Adel Gomaa +4 more
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Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin [PDF]
Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes.
Beatrice E. Bachmeier +19 more
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Neuroprotection and Estrogen Receptors [PDF]
This review is intended to assess the state of current knowledge on the role of estrogen receptors (ERs) in the neuroprotective effects of estrogens in models for acute neuronal injury and death. We evaluate the overall evidence that estrogens are neuroprotective in acute injury and critically assess the role of ERα, ERβ, GPR 30, and nonreceptor ...
James W, Simpkins +3 more
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The Role of Estrogen Receptors in Urothelial Cancer
Epidemiological data have indicated that there are some sex-related differences in bladder cancer. Indeed, the incidence of bladder cancer in men has been substantially higher than that in women throughout the world, while women tend to have higher stage
Takuro Goto +4 more
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A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen [PDF]
SynthSys is a Centre for Integrative Systems Biology (CISB) funded by BBSRC and EPSRC, reference BB/D019621/1.Background: Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy ...
Harrison, David J +11 more
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Estrogen-dependent dynamic profile of eNOS-DNA associations in prostate cancer [PDF]
In previous work we have documented the nuclear translocation of endothelial NOS (eNOS) and its participation in combinatorial complexes with Estrogen Receptor Beta (ERβ) and Hypoxia Inducible Factors (HIFs) that determine localized chromatin remodeling ...
Arturo Londono-Vallejo +55 more
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