Results 71 to 80 of about 828,897 (303)

Mechanism of Estrogen and Estrogen Receptors in Pathologic Pain [PDF]

Zhongguo quanke yixue
Pathologic pain is a serious chronic disease, including inflammatory pain, neuropathic pain and cancer pain. Previous studies have proved a close correlation of estrogen and its receptors with pathologic pain, which plays an important role in its ...
HE Bangjing, ZHOU Mingwang, ZHANG Pengwei
doaj   +1 more source

Epigenetics and the Estrogen Receptor

Annals of the New York Academy of Sciences, 2006
Abstract:  The position effect variegation in Drosophila and Schizosaccharomyces pombe, and higher‐order chromatin structure regulation in yeast, is orchestrated by modifier genes of the Su(var) group, (e.g., histone deacetylases ([HDACs]), protein phosphatases) and enhancer E(Var) group (e.g., ATP [adenosine 5′‐triphosphate]‐dependent nucleosome ...
Leader, Jennifer E., Wang, Chenuang, Popov, Vladimir M., Fu, Maofu, Pestell, Richard G.   +4 more
openaire   +3 more sources

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cardiac myocytes and fibroblasts contain functional estrogen receptors. [PDF]

, 1997
peer reviewedGender-based differences found in cardiovascular diseases raise the possibility that estrogen may have direct effects on cardiac tissue. Therefore we investigated whether cardiac myocytes and fibroblasts express functional estrogen receptors.
Karas, Richard H., Stimpel, Michael, Richard H. Karas, Ludwig Neyses, Vetter, Hans, Kahlert, S., Karas, R. H., Kerstin Löbbert, Lobbert, K., Vetter, H., Kahlert, Stefan, Grohe, C., Löbbert, Kerstin, Christian Grohé, Grohé, Christian, Michael Stimpel, Hans Vetter, NEYSES, Ludwig, Stimpel, M., Stefan Kahlert   +19 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Estrogen Receptors in the Male [PDF]

Archives of Andrology, 1981
Estrogens in the male are secreted by the testes and derived extragonadally from the aromatization of certain androgens. In some brain regions critical for the control of gonadotropin secretion and behavior, androgens may be aromatized to estrogens within the cells that are regulated. Estrogen may have other physiological roles on the testes to control
R B, Dickson, C R, Clark
openaire   +2 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Effects of estrogen receptor and estrogen on the chromatin structure in estrogen receptor stable transfectants [PDF]

Experimental & Molecular Medicine, 2002
The estrogen receptor (ER), a member of the nuclear hormone receptor superfamily recruits coactivators that modify local chromatin structure. Here we investigated the effect of the estrogen receptor and estrogen on the global chromatin structure and the local chromatin structure of the progesterone receptor gene during the process of transcriptional ...
Young Joo, Lee, Won Chung, Lim, Ying Hua, Jin, Seung Ki, Lee   +3 more
openaire   +2 more sources

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source