Results 61 to 70 of about 828,897 (303)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Supplementary Figure from Modulation of the Estrogen/erbB2 Receptors Cross-talk by CDK4/6 Inhibition Triggers Sustained Senescence in Estrogen Receptor– and ErbB2-positive Breast Cancer

, 2022
Supplementary Figure from Modulation of the Estrogen/erbB2 Receptors Cross-talk by CDK4/6 Inhibition Triggers Sustained Senescence in Estrogen Receptor– and ErbB2-positive Breast ...
Stefania Zambelli (15045897), Carlo Tacchetti (252415), Giampaolo Bianchini (15033890), Milvia Zambetti (14988543), Barbara Galbardi (15033896), Tiziana Daniele (14936204), Alberta Locatelli (15045891), Lucia Viganò (15045888), Matteo Dugo (136516), Balázs Győrffy (110652), Lorenzo Sica (15025347), Luca Gianni (15033911), Adele Ulisse (15045894), Diego Tosi (5626166), Marina Macchini (9913896)   +14 more
core   +3 more sources

Estrogen Actions in Triple-Negative Breast Cancer

Cells, 2020
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC.
Oliver Treeck, Susanne Schüler-Toprak, Olaf Ortmann   +2 more
doaj   +1 more source

A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen [PDF]

, 2012
SynthSys is a Centre for Integrative Systems Biology (CISB) funded by BBSRC and EPSRC, reference BB/D019621/1.Background: Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy ...
Harrison, David J, Kenneth Macleod, Yamaguchi, Azusa, Macleod, Kenneth, Galina Lebedeva, David J Harrison, Lebedeva, Galina, Langdon, Simon P., Langdon, Simon P, Azusa Yamaguchi, Harrison, David J., Simon P Langdon, Harrison, David J.; id_orcid   +12 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Estrogen Receptors and Endothelium [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2010
Estrogens, and in particular 17β-estradiol (E2), play a pivotal role in sexual development and reproduction and are also implicated in a large number of physiological processes, including the cardiovascular system. Both acetylcholine-induced and flow-dependent vasodilation are preserved or potentiated by estrogen treatment in both animal models and ...
Arnal, Jean-François, Fontaine, Coralie, Billon-Galés, Audrey, Favre, Julie, Laurell, Henrik, Lenfant, Françoise, Gourdy, Pierre   +6 more
openaire   +3 more sources

Estrogen receptors molecular action mechanisms [PDF]

, 2021
The article provides an overview of studies on estrogen receptors and their mechanisms of action. The article focuses on the structure of nuclear receptors (ERα and ERβ), as well as the main cellular reactions associated with them.
Izmozherova, N. V., Харина, Е. А., Korotkova, E. A., Короткова, Е. А., Бахтин, В. М., Kharina, E. A., Bakhtin, V. M., Изможерова, Н. В.   +7 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

The role of estrogen receptors in intestinal homeostasis and disease [PDF]

, 2016
Estrogen has a pivotal role in many biological functions in both reproductive and non-reproductive organs, mediating actions through its receptors, estrogen receptor ? (ER?) and ER?.
Narantsog Choijookhuu, Shin-ichiro Hino, Phyu Synn Oo, Baatarsuren Batmunkh, Yoshitaka Hishikawa
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source