Results 41 to 50 of about 131,688 (382)
WISDOM: history and early demise - was it inevitable?
, 2007 In 1989, the UK Medical Research Council (MRC) agreed that, if feasible, a randomized controlled trial to assess the long-term risks and benefits of hormone replacement therapy (HRT) was a priority.
Darbyshire, J, Meade, T, Vickers, M
core +1 more source
Effect of tibolone on breast cancer cell proliferation in postmenopausal ER+ patients: Results from STEM trial [PDF]
, 2007 Purpose: Tibolone is a selective tissue estrogenic activity regulator, approved for the treatment of vasomotor symptoms in postmenopausal women. We have done an exploratory, double-blind, randomized, placebo-controlled pilot trial to investigate the ...
Dowsett, Mitch +10 more
core +2 more sources
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie, EarlyView.Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker +3 more
wiley +2 more sources
Effects of estrogen replacement therapy on symptoms and clinical parameters in post menopausal women [PDF]
المجلة العراقية للصيدلة, 2011 Objective: To evaluate the effect of oral estrogen replacement therapy (ERT) in healthy postmenopausal women on lipid profile, body mass index (BMI), blood pressure, and blood glucose; and on postmenopausal symptoms.
Norjihan Ali Shaban, Kawa Dizaye
doaj +1 more source
Double robust estimation of partially adaptive treatment strategies [PDF]
arXiv, 2021 Precision medicine aims to tailor treatment decisions according to patients' characteristics. G-estimation and dynamic weighted ordinary least squares (dWOLS) are double robust statistical methods that can be used to identify optimal adaptive treatment strategies.
arxiv
Male and female sex hormones in primary headaches [PDF]
, 2018 Background: The three primary headaches, tension-type headache, migraine and cluster headache, occur in both genders, but all seem to have a sex-specific prevalence.
Alberto Terrin +9 more
core +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation [PDF]
Phys. Rev. Lett. 96, 198102 (2006), 2006 In human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with random kinetic rates.
arxiv +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Hormonal therapies and venous thrombosis: Considerations for prevention and management
Research and Practice in Thrombosis and Haemostasis, 2022 Background Venous thromboses are well‐established complications of hormonal therapy. Thrombosis risk is seen with both hormonal contraceptive agents and with hormone replacement therapy for menopause and gender transition.
Corinne LaVasseur +5 more
doaj +1 more source