Results 31 to 40 of about 50,235 (294)

Antithrombotic therapy for coronary artery disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

, 2004
This chapter about antithrombotic therapy for coronary artery disease (CAD) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do,
Christopher M. O'Connor, O'Connor, Christopher M, Meade, Thomas W, Guyatt, Gordon H, Becker, Richard C, David A. Vorchheimer, Harrington, Robert A, Michael Ezekowitz, Ezekowitz, Michael, Thomas W. Meade, Vorchheimer, David A, Gordon H. Guyatt, Robert A. Harrington, Richard C. Becker   +13 more
core   +1 more source

Hormonal therapies and venous thrombosis: Considerations for prevention and management

Research and Practice in Thrombosis and Haemostasis, 2022
Background Venous thromboses are well‐established complications of hormonal therapy. Thrombosis risk is seen with both hormonal contraceptive agents and with hormone replacement therapy for menopause and gender transition.
Corinne LaVasseur, Suvi Neukam, Thomas Kartika, Bethany Samuelson Bannow, Joseph Shatzel, Thomas G. DeLoughery   +5 more
doaj   +1 more source

WISDOM: history and early demise - was it inevitable?

, 2002
In 1989, the UK Medical Research Council (MRC) agreed that, if feasible, a randomized controlled trial to assess the long-term risks and benefits of hormone replacement therapy (HRT) was a priority.
Darbyshire, J, Meade, T, Vickers, M
core   +1 more source

Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes [PDF]

, 2007
Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen)
Sturdee, D. W., D. W. Sturdee, Palin, SL, Barnett, Anthony, S. L. Palin, K. C. McGee, Kumar, Sudhesh, McTernan, PG, McTernan, P. G., Barnett, A. H., Sturdee, David, Kumar, S, A. H. Barnett, McGee, K. C., McGee, KC, P. G. McTernan, Palin, S. L., S. Kumar   +17 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

High-Dose Estradiol-Replacement Therapy Enhances the Renal Vascular Response to Angiotensin II via an AT2-Receptor Dependent Mechanism

Advances in Pharmacological Sciences, 2015
Physiological levels of estrogen appear to enhance angiotensin type 2 receptor- (AT2R-) mediated vasodilatation. However, the effects of supraphysiological levels of estrogen, analogous to those achieved with high-dose estrogen replacement therapy in ...
Tahereh Safari, Mehdi Nematbakhsh, Roger G. Evans, Kate M. Denton   +3 more
doaj   +1 more source

Estrogen treatment and periodontal disease progression: an experimental study in ovariectomized rats

Brazilian Dental Science, 2012
The aim of this study was to investigate different periods of estrogen replacement therapy onset on the progression of experimental periodontitis in ovariectomized rats. MATERIAL AND METHODS: Sixty five female Wistar rats were ovariectomized and divided
Marianne Spalding, Priscila Ferreira Amschilnger, Marcela Almeida Prado, Ivan Balducci, Yasmin Rodarte Carvalho   +4 more
doaj   +1 more source

Antithrombotic treatment and the incidence of angina pectoris. [PDF]

, 2002
BACKGROUND: In primary prevention, anticoagulation with warfarin sodium to an international normalized ratio of 1.5 and 75 mg of aspirin per day each reduced the incidence of coronary heart disease (CHD). Effects on the development of angina pectoris and
Medical Research Council's General Practice Research Framework, Knottenbelt, Christine, Brennan, Patrick J, Meade, Tom W   +3 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source