Results 31 to 40 of about 50,421 (294)

Cardiovascular disease--linking pathology and epidemiology. [PDF]

, 2001
BACKGROUND: Coronary heart disease (CHD) in the form of myocardial infarction first came to attention early in the 20th century. Mortality from CHD increased dramatically after the First World War and had assumed epidemic proportions, particularly in the
Meade, TW
core   +1 more source

Influence of sexual dimorphism on satellite cell regulation and inflammatory response during skeletal muscle regeneration

Physiological Reports, 2023
After injury, skeletal muscle regenerates thanks to the key role of satellite cells (SC). The regeneration process is supported and coordinated by other cell types among which immune cells. Among the mechanisms involved in skeletal muscle regeneration, a
Charline Jomard, Julien Gondin
doaj   +1 more source

Frequency of the Causes of Postmenopausal Bleeding, Results of a Tertiary Referral Center in Turkey

Gynecology Obstetrics & Reproductive Medicine, 2021
OBJECTIVE: In this study, we aimed to determine the frequency of etiologic factors that causes postmenopausal bleeding. STUDY DESIGN: For the purpose, a total number of 200 women with postmenopausal bleeding were included in the study.
Umit Yasemin Sert, Ismail Guler, Tuncay Nas   +2 more
doaj   +1 more source

Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions

Biomedicines, 2022
Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and complications of ...
Szidónia Farkas, Adrienn Szabó, Anita Emőke Hegyi, Bibiána Török, Csilla Lea Fazekas, Dávid Ernszt, Tamás Kovács, Dóra Zelena   +7 more
doaj   +1 more source

Hormonal therapies and venous thrombosis: Considerations for prevention and management

Research and Practice in Thrombosis and Haemostasis, 2022
Background Venous thromboses are well‐established complications of hormonal therapy. Thrombosis risk is seen with both hormonal contraceptive agents and with hormone replacement therapy for menopause and gender transition.
Corinne LaVasseur, Suvi Neukam, Thomas Kartika, Bethany Samuelson Bannow, Joseph Shatzel, Thomas G. DeLoughery   +5 more
doaj   +1 more source

Distinct roles of estrone and estradiol in endothelial colony‐forming cells

Physiological Reports, 2023
Our current understanding of the relationship between estrogen and human endothelial colony‐forming cell (hECFC) function is based almost exclusively on studies investigating estradiol action at nuclear estrogen receptors.
Alicia Ivory, Andrew S. Greene
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes [PDF]

, 2007
Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen)
Sturdee, D. W., D. W. Sturdee, Palin, SL, Barnett, Anthony, S. L. Palin, K. C. McGee, Kumar, Sudhesh, McTernan, PG, McTernan, P. G., Barnett, A. H., Sturdee, David, Kumar, S, A. H. Barnett, McGee, K. C., McGee, KC, P. G. McTernan, Palin, S. L., S. Kumar   +17 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

High-Dose Estradiol-Replacement Therapy Enhances the Renal Vascular Response to Angiotensin II via an AT2-Receptor Dependent Mechanism

Advances in Pharmacological Sciences, 2015
Physiological levels of estrogen appear to enhance angiotensin type 2 receptor- (AT2R-) mediated vasodilatation. However, the effects of supraphysiological levels of estrogen, analogous to those achieved with high-dose estrogen replacement therapy in ...
Tahereh Safari, Mehdi Nematbakhsh, Roger G. Evans, Kate M. Denton   +3 more
doaj   +1 more source