Results 31 to 40 of about 162,839 (298)

Algal extracellular organic matter mediated photocatalytic degradation of estrogens

Ecotoxicology and Environmental Safety, 2021
Estrogens are among the most concerned emerging contaminants in the wastewater treatment effluent due to their sexual disruption in aquatic wildlife. The use of microalgae for secondary wastewater effluent polishing is a promising approach due to the ...
Pei-Hsun Wu, Hsin-Yi Yeh, Pei-Hsin Chou, Wen-Wei Hsiao, Chang-Ping Yu   +4 more
doaj   +1 more source

Seasonal dynamics, sources, and ecological risk of estrogens in a freeze-thaw basin: Implications for aquatic ecosystems

Ecotoxicology and Environmental Safety
Estrogens have attracted extensive attention because of their harmful effects on organisms such as endocrine disturbance and reproductive toxicity. This study investigated the spatial and temporal distribution and ecological risk assessment of 7 targeted
Jiamei Wang, Tianzhi Li, Wei Ouyang, Xin Hao, Yan Bai, Shangwei Zhang, Chunye Lin, Mengchang He, Xitao Liu   +8 more
doaj   +1 more source

Signaling by estrogens [PDF]

Journal of Cellular Physiology, 2007
AbstractBy regulating activities and expression levels of key signaling molecules, estrogens control mechanisms that are responsible for crucial cellular functions. Ligand binding to estrogen receptor (ER) leads to conformational changes that regulate the receptor activity, its interaction with other proteins and DNA.
Boris J. Cheskis, Sunil Nagpal, James G. Greger, Leonard P. Freedman   +3 more
openaire   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Equine estrogens differentially inhibit DNA fragmentation induced by glutamate in neuronal cells by modulation of regulatory proteins involved in programmed cell death

BMC Neuroscience, 2003
Background Recent data indicate that excitotoxicity of high levels of neurotransmitter glutamate may be mediated via programmed cell death (apoptosis) and that it can be prevented in HT22 mouse hippocampal cells by various equine estrogens with Δ8,17β ...
Lu XiaoFeng, Zhang YueMei, Bhavnani Bhagu R   +2 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens

Biomedicines
The role of estrogens in prostate cancer (PCa) is shrouded in mystery, with its actions going from angelic to devilish. The findings by Huggins and Hodges establishing PCa as a hormone-sensitive cancer have provided the basis for using estrogens in ...
Marília I. Figueira, Tiago M. A. Carvalho, Joana Macário-Monteiro, Henrique J. Cardoso, Sara Correia, Cátia V. Vaz, Ana P. Duarte, Sílvia Socorro   +7 more
doaj   +1 more source

Metabolic alteration of circulating steroid hormones in women with gestational diabetes mellitus and the related risk factors

Frontiers in Endocrinology, 2023
BackgroundAbnormally changed steroid hormones during pregnancy are closely related to the pathological process of gestational diabetes mellitus (GDM). Our aim was to systematically profile the metabolic alteration of circulating steroid hormones in GDM ...
Na Yang, Na Yang, Wei Zhang, Cheng Ji, Jiajia Ge, Xiaoli Zhang, Meijuan Li, Min Wang, Tianqi Zhang, Jun He, Huaijun Zhu   +10 more
doaj   +1 more source