Isoenzyme- and Allozyme-Specific Inhibitors: 2,20-Dihydroxybenzophenones and Their Carbonyl N-Analogues that Discriminate between Human Glutathione Transferase A1-1 and P1-1 Allozymes [PDF]
, 2015 The selectivity of certain benzophenones and their carbonyl N-analogues was investigated towards the human GSTP1-1 allozymes A, B and C involved in MDR. The allozymes were purified from extracts derived from E.
Clonis, Yannis D. +5 more
core +1 more source
Journal of Cellular and Molecular Medicine, Volume 28, Issue 8, April 2024.Abstract Liver hepatocellular carcinoma (LIHC) is a significant global health issue with limited treatment options. In this study, single‐cell RNA sequencing (scRNA‐seq) data were used to explore the molecular mechanisms of LIHC development and identify potential targets for therapy.
Yumeng Wang +5 more
wiley +1 more source
The potential of mid-infrared photoacoustic spectroscopy for the detection of various doping agents used by athletes [PDF]
, 2018 The feasibility of laser-photoacoustic measurements for the detection and the analysis of different isolated doping agents in the vapour phase is discussed. To the best of our knowledge, this is the first time that photoacoustic vapour-phase measurements
Bartlome, R., Fischer, C., Sigrist, M.W.
core
The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43 [PDF]
, 2014 Pathological aggregates of phosphorylated TDP-43 characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), two devastating groups of neurodegenerative disease.
Bird, Thomas D. +11 more
core +4 more sources
Supplementary Figure 7 from Ethacrynic Acid and a Derivative Enhance Apoptosis in Arsenic Trioxide–Treated Myeloid Leukemia and Lymphoma Cells: The Role of Glutathione S-Transferase P1-1 [PDF]
, 2023 Rui Wang +6 more
openalex +1 more source
Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 152-167, February 2024.Abstract Background The antineoplastic drug busulfan can induce different hepatic lesions including cholestasis and sinusoidal obstruction syndrome. However, hepatic steatosis has never been reported in patients. Objectives This study aimed to determine whether busulfan could induce steatosis in primary human hepatocytes (PHH) and differentiated HepaRG
Julien Allard +4 more
wiley +1 more source
Purification and Characterization of Glutathione S-Transferase from rabbit liver [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعيةGlutathione S-transferases (GSTs) are essential enzymes involved in the detoxification process in animals. They catalyze the conjugation of the antioxidant glutathione (GSH) to various electrophilic compounds, such as environmental toxins, carcinogens ...
Abdelrahim A. Hunaiti, Ahmad Al hadidi
doaj +1 more source
Partial Purification and Characterization of Glutathione S-Transferase from the Livers of Malaysian Catfish (Clarias Batrachus) and Malaysian Red Tilapia (Oreochromis Sp.) [PDF]
, 2005 The present study is concerned mainly with partial purification and characterization of cytosolic GST from livers of Malaysian catfish and Malaysian red tilapia as both species are of economic and commercial importance in Malaysia being the major ...
Chin, Chee Meng
core
A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers. [PDF]
, 2016 Aberrant WNT signaling underlies cancerous transformation and growth in many tissues, such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired mode of development of targeted therapies against these cancers.
Ahmed, K. +3 more
core +3 more sources
Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines [PDF]
, 2014 BACKGROUND: Chemotherapy response in ovarian cancer patients is frequently compromised by drug resistance, possibly due to altered drug metabolism. Platinum drugs are metabolised by glutathione S-transferase P1 (GSTP1), which is abundantly, but variably ...
A De Luca +67 more
core +2 more sources