Results 81 to 90 of about 6,190 (242)
Molecular Cloning, Expression, And Characterization Of Glutathione-Stransferase As A Novel Target In Antimalarial Drug Design And Discovery [PDF]
, 2015 Glutation-S-transferase (GSTs) adalah sekumpulan enzim detoksifikasi. Plasmodium falciparum mempunyai isoform tunggal GST (PfGST) yang terlibat dalam bagi detoksifikasi heme. The Glutathione-S-transferases (GSTs) are group of detoxification enzymes.
Al-Qattan, Mohammed Nooraldeen Mahmod
core
Increased nitric oxide activity compensates for increased oxidative stress to maintain endothelial function in rat aorta in early type 1 diabetes [PDF]
, 2012 Hyperglycaemia and oxidative stress are known to acutely cause endothelial dysfunction in vitro, but in the initial stages of diabetes, endothelium-dependent relaxation is preserved.
Joshi, A, Woodman, O
core +1 more source
Cancer Medicine, Volume 13, Issue 18, September 2024.A new mechanism of cancer initiation that involves the transformation of hepatocytes into preneoplastic single hepatocytes and minifoci positive for GST‐P was identified in the rat liver on the key finding of “rapid excretion of GST‐P into bile” obtained from 3D immunochemistry using a vibratome for the first time.
Kimihiko Satoh
wiley +1 more source
Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin
Biochemistry Research International, 2016 Glutathione transferases (GSTs) are part of a major family of detoxifying enzymes that can catalyze the reductive dehydrochlorination of dichlorodiphenyltrichloroethane (DDT).
Patience Marimo +2 more
doaj +1 more source
Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo
Redox Biology, 2019 Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH utilization during development remains understudied. Monochlorobimane (MCB), a dye conjugated
Archit Rastogi +4 more
doaj +1 more source
Ethacrynic Acid Ototoxicity Potentiation by Kanamycin [PDF]
Annals of Otology, Rhinology & Laryngology, 1973 The ototoxicity of ethacrynic acid and kanamycin in combination has been investigated during acute and chronic conditions of exposure. The effect of the combination of 10 mg/kg of ethacrynic acid and 100 mg/kg of kanamycin during both exposure conditions is manifested by a significantly greater drop in measured potentials than is present in the ...
J, Prazma, J P, Browder, N D, Fischer
openaire +2 more sources
Paediatric and Perinatal Epidemiology, Volume 38, Issue 6, Page 495-504, August 2024.Abstract Background Off‐label treatment of extremely preterm infants with diuretics and inhaled corticosteroids (ICS) for evolving bronchopulmonary dysplasia (BPD) is common. Their effectiveness in reducing mortality or BPD severity, and optimal treatment timing, are unclear.
Jonathan L. Slaughter +2 more
wiley +1 more source
Glutathione-conjugating and membrane-remodeling activity of GDAP1 relies on amphipathic C-terminal domain [PDF]
, 2016 Mutations in the ganglioside-induced differentiation associated protein 1 (GDAP1) cause severe peripheral motor and sensory neuropathies called Charcot-Marie-Tooth disease.
Berger, Imre +6 more
core +2 more sources
Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins
Acta Physiologica, Volume 240, Issue 6, June 2024.Abstract A disturbed mitochondrial function contributes to the pathology of many common diseases. These organelles are therefore important therapeutic targets. On the contrary, many adverse effects of drugs can be explained by a mitochondrial off‐target effect, in particular, due to an interaction with carrier proteins in the inner membrane.
Charlotte A. Hoogstraten +2 more
wiley +1 more source
FEBS Open Bio, Volume 14, Issue 5, Page 726-739, May 2024.Glutathione transferases (GST) are involved in detoxification and immunomodulation, allowing the establishment and development of cestodes in the host. Taenia solium has a 24‐kDa GST sigma class inducible gene that encodes a stable enzyme in a wide range of pHs and temperatures. Its enzymatic activity differs from other GSTs in the parasite, suggesting
Ricardo Miranda‐Blancas +7 more
wiley +1 more source