Ether-a-go-go related gene-1a potassium channel abundance varies within specific skeletal muscle fiber type [PDF]
European Journal of Translational Myology, 2019 The ERG1A K+ channel, which is partially responsible for repolarization of the cardiac action potential, has also been reported in skeletal muscle where it modulates ubiquitin proteolysis. Because ERG1A protein appears variably expressed in muscles composed of mixed fiber types, we hypothesized that its abundance in skeletal muscle might differ with ...
Anderson, Luke B. +5 more
core +8 more sources
Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin. [PDF]
EMBO J, 2000 Intracellular Ca(2+) inhibits voltage-gated potassium channels of the ether à go-go (EAG) family. To identify the underlying molecular mechanism, we expressed the human version hEAG1 in Xenopus oocytes. The channels lost Ca(2+) sensitivity when measured in cell-free membrane patches.
Schönherr R, Löber K, Heinemann SH.
europepmc +6 more sources
Natural antisense transcripts regulate the neuronal stress response and excitability [PDF]
eLife, 2014 Neurons regulate ionic fluxes across their plasma membrane to maintain their excitable properties under varying environmental conditions. However, the mechanisms that regulate ion channels abundance remain poorly understood.
Xingguo Zheng +3 more
doaj +4 more sources
Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator. [PDF]
PLoS ONE, 2018 We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel ...
Ancy Joseph +3 more
doaj +4 more sources
Aggregation-Induced Emission: Lighting Up hERG Potassium Channel [PDF]
Frontiers in Chemistry, 2019 Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE).
Xiaomeng Zhang +4 more
doaj +3 more sources
Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating. [PDF]
PLoS ONE, 2011 A conserved eag domain in the cytoplasmic amino terminus of the human ether-a-go-go-related gene (hERG) potassium channel is critical for its slow deactivation gating.
Jorge Fernández-Trillo +5 more
doaj +4 more sources
Potassium dependent structural changes in the selectivity filter of HERG potassium channels [PDF]
Nature CommunicationsThe fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go related gene (HERG) potassium channels have uniquely rapid
Carus H. Y. Lau +10 more
doaj +2 more sources
Discovery of a novel broad-spectrum inhibitor against influenza virus A [PDF]
Virology JournalThe pandemic of influenza A virus (IAV) is on the rise worldwide, however, drug resistance to anti-influenza drugs has been widely found. The viral mutation of IAV highlights the necessitate for discovery of new antiviral agents with broad-spectrum ...
Ran Yu, Peng Li, Rong Shen, Wenting Fei
doaj +2 more sources
BMC Bioinformatics, 2017 Background Blockage of some ion channels and in particular, the hERG (human Ether-a’-go-go-Related Gene) cardiac potassium channel delays cardiac repolarization and can induce arrhythmia.
Mohsen Sharifi +3 more
doaj +3 more sources
Case report: Ivabradine induced Torsades de Pointes
IHJ Cardiovascular Case Reports, 2023 Ivabradine is used to control heart rate in patients of heart failure with reduced ejection fraction. Although considered safe, it is reported to prolong QTc interval when given with other QTc prolonging drugs or in setting of hypokalemia or ...
Mohit M. Bhagwati +2 more
doaj +1 more source