Results 21 to 30 of about 22,847 (294)
Ether-a-go-go Related Gene Potassium Channels: What's All the Buzz About? [PDF]
Schizophrenia Bulletin, 2006 Antipsychotic drugs are thought to exert their therapeutic action by antagonizing dopamine receptors but are also known to produce side effects in the heart by inhibiting cardiac ether-a-go-go-related gene (ERG) K(+) channels. Recently, it has been discovered that the same channels are present in the brain, including midbrain dopamine neurons.
Donald S. Shepard +2 more
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Andrologia, 2021 In recent studies, it has been reported that ion channels play an important role in cancer formation. Therefore, it is possible that the use of pharmacological agents targeting ion channels will allow the development of new strategies for cancer treatment.
Fatma Söğüt +5 more
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NBD-Based Environment-Sensitive Fluorescent Probes for the Human Ether-a-Go-Go–Related Gene Potassium Channel [PDF]
Frontiers in Molecular Biosciences, 2021 Three environment-sensitive probes were developed for the hERG channel based on the nitrobenzoxadiazole fluorophore herein. After careful evaluation, probes M1 and M3 were found to have a high affinity for imaging the hERG channel in the cell-based experiment.
Qi Li +4 more
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Ether ℵ go-go Potassium Channels KCNH1 and KCNH5 Have Four Functional Orthologs in Danio Rerio [PDF]
Biophysical Journal, 2010 The human ether a go-go channels KCNH1 and KCNH5 form a subgroup with unique functional properties within the eight-membered KCNH family of voltage-gated potassium channels. In mammals, the expression of both genes is mainly restricted to the brain, implying a role in electrical signaling of neurons.
Rayk Stengel +4 more
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Human Ether á-go-go Gene Potassium Channels Are Regulated by EGFR Tyrosine Kinase [PDF]
Biophysical Journal, 2009 Human ether á-go-go gene potassium channels (hEAG1) are expressed in brain and several types of human cancers and play a critical role in neuronal excitement and tumor progression. However, functional regulation of hEAG1 channels is not understood. The present study was designed to determine whether hEAG1 channels are regulated by EGFR kinase in HEK ...
Weihua Wu, C.P. Lau, H.F. Tse, G.R. Li
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Intracellular Potassium Stabilizes HumanEther-à-go-go-Related Gene Channels for Export from Endoplasmic Reticulum [PDF]
Molecular Pharmacology, 2009 Several therapeutic compounds have been identified that prolong the QT interval on the electrocardiogram and cause torsade de pointes arrhythmias not by direct block of the cardiac potassium channel human ether-à-go-go-related gene (hERG) but via disruption of hERG trafficking to the cell surface membrane. One example of a clinically important compound
Lu Wang +7 more
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Aberrant expression of ether à go-go potassium channel in colorectal cancer patients and cell lines [PDF]
World Journal of Gastroenterology, 2007 To study the expression of ether à go-go (Eag1) potassium channel in colorectal cancer and the relation-ship between their expression and clinico-pathological features.The expression levels of Eag1 protein were determined in 76 cancer tissues with paired non-cancerous matched tissues as well as 9 colorectal adenoma tissues by immunohistochemistry. Eag1
Xiangwu Ding
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BMC Bioinformatics, 2017 Background Blockage of some ion channels and in particular, the hERG (human Ether-a’-go-go-Related Gene) cardiac potassium channel delays cardiac repolarization and can induce arrhythmia.
Mohsen Sharifi +3 more
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Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma [PDF]
Biologics: Targets & Therapy, 2016 María de Guadalupe Chávez-López,1 Violeta Zúñiga-García,1 Julio Isael Pérez-Carreón,2 Arturo Avalos-Fuentes,3 Yesenia Escobar,4 Javier Camacho1 1Department of Pharmacology, Centro de Investigaci ...
Chávez-López MG +5 more
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Toxins, 2021 The Colombian scorpion Centruroides margaritatus produces a venom considered of low toxicity. Nevertheless, there are known cases of envenomation resulting in cardiovascular disorders, probably due to venom components that target ion channels. Among them,
José Beltrán-Vidal +7 more
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