Results 21 to 30 of about 30,487 (240)

Environment-Sensitive Fluorescent Probe for the Human Ether-a-go-go-Related Gene Potassium Channel [PDF]

Analytical Chemistry, 2016
A novel environment-sensitive probe S2 with turn-on switch for Human Ether-a-go-go-Related Gene (hERG) potassium channel was developed herein. After careful evaluation, this fluorescent probe showed high binding affinity with hERG potassium channel with an IC50 value of 41.65 nM and can be well applied to hERG channel imaging or cellular distribution ...
Liu, Zhenzhen, Jiang, Tianyu, Wang, Beilei, Ke, Bowen, Zhou, Yubin, Du, Lupei, Li, Minyong   +6 more
openaire   +2 more sources

The environmental toxicant ziram enhances neurotransmitter release and increases neuronal excitability via the EAG family of potassium channels

Neurobiology of Disease, 2020
Environmental toxicants have the potential to contribute to the pathophysiology of multiple complex diseases, but the underlying mechanisms remain obscure.
Jenna Harrigan, Daisy F. Brambila, Pratap Meera, David E. Krantz, Felix E. Schweizer   +4 more
doaj   +1 more source

Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1

Scientific Reports, 2022
Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has been a growing
Nirakar Sahoo, Kefan Yang, Ina Coburger, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann   +11 more
doaj   +1 more source

β-Arrestin-Mediated Regulation of the Human Ether-a-go-go-Related Gene Potassium Channel [PDF]

Molecular Pharmacology, 2017
The rapidly activating delayed rectifier K+ channel (IKr) is encoded by the human ether-a-go-go-related gene (hERG), which is important for the repolarization of the cardiac action potential. Mutations in hERG or drugs can impair the function or decrease the expression level of hERG channels, leading to long QT syndrome.
Matthew G, Sangoi, Shawn M, Lamothe, Jun, Guo, Tonghua, Yang, Wentao, Li, Ellen G, Avery, John T, Fisher, Shetuan, Zhang   +7 more
openaire   +2 more sources

Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility

Physiological Reports, 2023
In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle.
Vincenzo Barrese, Zena Wehbe, Alice Linden, Sarah McDowell, Elizabeth Forrester, Oleksander Povstyan, Karen D. McCloskey, Iain A. Greenwood   +7 more
doaj   +1 more source

Parallel Recordings of Transmembrane hERG Channel Currents Based on Solvent-Free Lipid Bilayer Microarray

Micromachines, 2021
The reconstitution of ion-channel proteins in artificially formed bilayer lipid membranes (BLMs) forms a well-defined system for the functional analysis of ion channels and screening of the effects of drugs that act on these proteins.
Ryusuke Miyata, Daisuke Tadaki, Daichi Yamaura, Shun Araki, Madoka Sato, Maki Komiya, Teng Ma, Hideaki Yamamoto, Michio Niwano, Ayumi Hirano-Iwata   +9 more
doaj   +1 more source

Eag and HERG potassium channels as novel therapeutic targets in cancer

World Journal of Surgical Oncology, 2010
Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential ...
Bali Anish, Shaw Robert, Sowter Heidi, Asher Viren, Khan Raheela   +4 more
doaj   +1 more source

Rac and Rho Mediate Opposing Hormonal Regulation of the Ether-A-Go-Go-Related Potassium Channel [PDF]

Current Biology, 2002
Previous studies of ion channel regulation by G proteins have focused on the larger, heterotrimeric GTPases, which are activated by heptahelical membrane receptors. In contrast, studies of the Rho family of smaller, monomeric, Ras-related GTPases, which are activated by cytoplasmic guanine nucleotide exchange factors, have focused on their role in ...
Storey, N.M., O'Bryan, J.P., Armstrong, D.L.   +2 more
openaire   +3 more sources

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. [PDF]

PLoS ONE, 2017
The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization.
Dahai Yu, Lin Lv, Li Fang, Bo Zhang, Junnan Wang, Ge Zhan, Lei Zhao, Xin Zhao, Baoxin Li   +8 more
doaj   +1 more source

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
core   +1 more source