Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. [PDF]
PLoS ONE, 2015 Human Ether á go-go Related Gene potassium channels form the rapid component of the delayed-rectifier (IKr) current in the heart. The N-terminal 'eag' domain, which is composed of a Per-Arnt-Sim (PAS) domain and a short PAS-cap region, is a critical ...
Qiang-Ni Liu, Matthew C Trudeau
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Structural modeling of hERG channel–drug interactions using Rosetta
Frontiers in Pharmacology, 2023 The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Aiyana M. Emigh Cortez +17 more
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The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. [PDF]
, 2011 The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death.
Anish Bali +6 more
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Eag1 Channels as Potential Cancer Biomarkers
Sensors, 2012 Cancer is a leading cause of death worldwide. New early tumor markers are needed to treat the disease at curable stages. In addition, new therapeutic targets are required to treat patients not responding to available treatments.
Javier Camacho +2 more
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Novel roles for hERG K+ channels in cell proliferation and apoptosis [PDF]
, 2011 The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular ...
Jehle, J +3 more
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Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]
, 2018 The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
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The molecular determinants of R-roscovitine block of hERG channels.
PLoS ONE, 2019 Human ether-à-go-go-related gene (Kv11.1, or hERG) is a potassium channel that conducts the delayed rectifier potassium current (IKr) during the repolarization phase of cardiac action potentials. hERG channels have a larger pore than other K+channels and
Bryan Cernuda +7 more
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Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance [PDF]
, 2013 Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of ...
Atkinson, Nigel S. +5 more
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Journal of Pharmacological Sciences, 2004 While aldosterone receptor blockers improve survival of patients with congestive heart failure, spironolactone and its derivatives were recently shown to block ether-a-go-go-related gene (HERG) channels and native IKs and IKr currents in guinea pig ...
Atsushi Sugiyama +7 more
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The Study on the hERG Blocker Prediction Using Chemical Fingerprint Analysis
Molecules, 2020 Human ether-a-go-go-related gene (hERG) potassium channel blockage by small molecules may cause severe cardiac side effects. Thus, it is crucial to screen compounds for activity on the hERG channels early in the drug discovery process.
Kwang-Eun Choi +2 more
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