Results 41 to 50 of about 22,847 (294)

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR

Nature Communications, 2022
Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic development and adult tissue homeostasis. Improving our understanding of this transition would facilitate our ability to manipulate pluripotent cells into ...
Emily Sempou, Valentyna Kostiuk, Jie Zhu, M. Cecilia Guerra, Leonid Tyan, Woong Hwang, Elena Camacho-Aguilar, Michael J. Caplan, David Zenisek, Aryeh Warmflash, Nick D. L. Owens, Mustafa K. Khokha   +11 more
doaj   +1 more source

Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating. [PDF]

PLoS ONE, 2011
A conserved eag domain in the cytoplasmic amino terminus of the human ether-a-go-go-related gene (hERG) potassium channel is critical for its slow deactivation gating.
Jorge Fernández-Trillo, Francisco Barros, Angeles Machín, Luis Carretero, Pedro Domínguez, Pilar de la Peña   +5 more
doaj   +1 more source

Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. [PDF]

PLoS ONE, 2015
Human Ether á go-go Related Gene potassium channels form the rapid component of the delayed-rectifier (IKr) current in the heart. The N-terminal 'eag' domain, which is composed of a Per-Arnt-Sim (PAS) domain and a short PAS-cap region, is a critical ...
Qiang-Ni Liu, Matthew C Trudeau
doaj   +1 more source

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
core   +1 more source

APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1

Marine Drugs, 2017
The human ether-à-go-go channel (hEag1 or KV10.1) is a cancer-relevant voltage-gated potassium channel that is overexpressed in a majority of human tumors. Peptides that are able to selectively inhibit this channel can be lead compounds in the search for
Lien Moreels, Steve Peigneur, Diogo T. Galan, Edwin De Pauw, Lászlo Béress, Etienne Waelkens, Luis A. Pardo, Loïc Quinton, Jan Tytgat   +8 more
doaj   +1 more source

Novel roles for hERG K+ channels in cell proliferation and apoptosis [PDF]

, 2011
The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular ...
Jehle, J, Katus, H A, Schweizer, P A, Thomas, D   +3 more
core   +2 more sources

Structural modeling of hERG channel–drug interactions using Rosetta

Frontiers in Pharmacology, 2023
The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Aiyana M. Emigh Cortez, Aiyana M. Emigh Cortez, Kevin R. DeMarco, Kevin R. DeMarco, Kazuharu Furutani, Kazuharu Furutani, Slava Bekker, Slava Bekker, Jon T. Sack, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Colleen E. Clancy, Colleen E. Clancy, Igor Vorobyov, Igor Vorobyov, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy   +17 more
doaj   +1 more source

Blockade of the human ether-a-go-go-related gene potassium channel by ketamine

Journal of Pharmacy and Pharmacology, 2013
Abstract Objectives The inhibition of the cardiac rapid delayed rectifier potassium current (IKr) and its cloned equivalent human ether-a-go-go-related gene (hERG) channel illustrate QT interval prolonging effects of a wide range of clinically used drugs.
Antao Luo, Chenghao Gao, Zhipei Liu, Junlian Xing, Juan Feng, Jihua Ma, Peihua Zhang   +6 more
openaire   +2 more sources

Case report: Ivabradine induced Torsades de Pointes

IHJ Cardiovascular Case Reports, 2023
Ivabradine is used to control heart rate in patients of heart failure with reduced ejection fraction. Although considered safe, it is reported to prolong QTc interval when given with other QTc prolonging drugs or in setting of hypokalemia or ...
Mohit M. Bhagwati, K.K. Talwar, Amitabh Yaduvanshi   +2 more
doaj  

Environment-Sensitive Fluorescent Probe for the Human Ether-a-go-go-Related Gene Potassium Channel [PDF]

Analytical Chemistry, 2016
A novel environment-sensitive probe S2 with turn-on switch for Human Ether-a-go-go-Related Gene (hERG) potassium channel was developed herein. After careful evaluation, this fluorescent probe showed high binding affinity with hERG potassium channel with an IC50 value of 41.65 nM and can be well applied to hERG channel imaging or cellular distribution ...
Minyong Li, Yubin Zhou, Lupei Du, Zhenzhen Liu, Bowen Ke, Beilei Wang, Tianyu Jiang   +6 more
openaire   +3 more sources