Results 51 to 60 of about 30,487 (240)
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue
Pharmaceuticals, 2023 hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of ...
Matthew V. Helliwell +4 more
doaj +1 more source
CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning [PDF]
, 2013 Calcium (Ca2+)/calmodulin (CaM)-dependent kinase II (CaMKII) activity plays a fundamental role in learning and memory. A key feature of CaMKII in memory formation is its ability to be regulated by autophosphorylation, which switches its activity on and ...
Gillespie, John M, Hodge, James J L
core +3 more sources
BMC Molecular and Cell Biology, 2021 Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1.
Kazuki Matsumura +14 more
doaj +1 more source
Anti-Ro/SSA Antibodies and the Autoimmune Long-QT Syndrome
Frontiers in Medicine, 2021 Autoimmunity is increasingly recognized as a novel pathogenic mechanism for cardiac arrhythmias. Several arrhythmogenic autoantibodies have been identified, cross-reacting with different types of surface proteins critically involved in the cardiomyocyte ...
Pietro Enea Lazzerini +4 more
doaj +1 more source
Proliferative role of Kv11 channels in murine arteries [PDF]
, 2017 K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1 and ERG1b) were identified in murine portal vein and distinctive voltage-gated K ...
Abbott +35 more
core +3 more sources
Post-Transcriptional Control of Human Ether-a-go-go-Related Gene Potassium Channel Protein by α-Adrenergic Receptor Stimulation [PDF]
Molecular Pharmacology, 2010 Stimulation of alpha1-adrenoreceptors (alpha1-AR) acutely alters ion channel behavior via several signaling pathways [calcium and protein kinase C (PKC)]. Little is known about sustained alpha1-adrenergic/PKC signaling and channel regulation as may occur during cardiovascular disease states.
Jian, Chen +6 more
openaire +2 more sources
14-3-3θ is a binding partner of rat Eag1 potassium channels. [PDF]
PLoS ONE, 2012 The ether-à-go-go (Eag) potassium (K(+)) channel belongs to the superfamily of voltage-gated K(+) channel. In mammals, the expression of Eag channels is neuron-specific but their neurophysiological role remains obscure.
Po-Hao Hsu +7 more
doaj +1 more source
In silico mechanisms of arsenic trioxide-induced cardiotoxicity
Frontiers in Physiology, 2022 It has been found that arsenic trioxide (ATO) is effective in treating acute promyelocytic leukemia (APL). However, long QT syndrome was reported in patients receiving therapy using ATO, which even led to sudden cardiac death.
Yacong Li +7 more
doaj +1 more source
Frontiers in Immunology, 2023 The functional relevance of K+ and Ca2+ ion channels in the “Store Operated Calcium Entry” (SOCE) during B and T lymphocyte activation is well proven. However, their role in the process of T- and B- cell development and selection is still poorly defined.
Cesare Sala +6 more
doaj +1 more source
BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells [PDF]
, 2012 INTRODUCTION: Bone marrow–derived mesenchymal stem cells (MSCs) are a promising cell source for regenerative medicine. However, cellular physiology is not fully understood in human MSCs.
Lau, CP, Li, GR, Tse, HF, Zhang, Y
core