Results 51 to 60 of about 22,847 (294)
Eag1 Channels as Potential Cancer Biomarkers
Sensors, 2012 Cancer is a leading cause of death worldwide. New early tumor markers are needed to treat the disease at curable stages. In addition, new therapeutic targets are required to treat patients not responding to available treatments.
Javier Camacho +2 more
doaj +1 more source
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]
, 2016 Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia +17 more
core +1 more source
Cyclic nucleotide-regulated channels (CNG) in GtoPdb v.2021.3 [PDF]
, 2021 Cyclic nucleotide-gated (CNG) channels are responsible for signalling in the primary sensory cells of the vertebrate visual and olfactory systems. CNG channels are voltage-independent cation channels formed as tetramers.
Becirovic, Elvir +5 more
core +2 more sources
Cyclic nucleotide-regulated channels (CNG) in GtoPdb v.2023.1 [PDF]
, 2023 Cyclic nucleotide-gated (CNG) channels are responsible for signalling in the primary sensory cells of the vertebrate visual and olfactory systems. CNG channels are voltage-independent cation channels formed as tetramers.
Becirovic, Elvir +5 more
core +2 more sources
The molecular determinants of R-roscovitine block of hERG channels.
PLoS ONE, 2019 Human ether-à-go-go-related gene (Kv11.1, or hERG) is a potassium channel that conducts the delayed rectifier potassium current (IKr) during the repolarization phase of cardiac action potentials. hERG channels have a larger pore than other K+channels and
Bryan Cernuda +7 more
doaj +1 more source
The Study on the hERG Blocker Prediction Using Chemical Fingerprint Analysis
Molecules, 2020 Human ether-a-go-go-related gene (hERG) potassium channel blockage by small molecules may cause severe cardiac side effects. Thus, it is crucial to screen compounds for activity on the hERG channels early in the drug discovery process.
Kwang-Eun Choi +2 more
doaj +1 more source
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue
Pharmaceuticals, 2023 hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of ...
Matthew V. Helliwell +4 more
doaj +1 more source
BMC Molecular and Cell Biology, 2021 Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1.
Kazuki Matsumura +14 more
doaj +1 more source
Anti-Ro/SSA Antibodies and the Autoimmune Long-QT Syndrome
Frontiers in Medicine, 2021 Autoimmunity is increasingly recognized as a novel pathogenic mechanism for cardiac arrhythmias. Several arrhythmogenic autoantibodies have been identified, cross-reacting with different types of surface proteins critically involved in the cardiomyocyte ...
Pietro Enea Lazzerini +4 more
doaj +1 more source
The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. [PDF]
, 2011 The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death.
Anish Bali +6 more
core +5 more sources