Results 111 to 120 of about 16,101,585 (240)

The Supreme Bioethics Committee in the new clinical trial ethics assessment system. Comments de lege ferenda and de lege lata

Journal of Modern Science
The aim of this article is to present the issues concerning the role and constitutional position of the Supreme Bioethics Commission in the system of ethical evaluation of clinical trials in Poland.
Monika Urbaniak
doaj   +1 more source

Ethical review of off-label drugs during the COVID-19 pandemic. [PDF]

World J Clin Cases, 2022
Li QY, Lv Y, An ZY, Dai NN, Hong X, Zhang Y, Liang LJ.   +6 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Ethical Review Challenges and Practices of Brain-Computer Interfaces Research in Psychiatry

Yixue yu zhexue
In psychiatric research involving brain-computer interface (BCI) technologies, most participants are individuals with severe, treatment-resistant conditions, whose urgent desire for relief may compromise their decision-making capacity.
Li LI, Lingling YE, Weimin YANG
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Addressing ethical issues in peer review - new guidelines available from COPE [PDF]

, 2017
Ethical issues related to the peer review process are increasingly complex and can be tricky to navigate and resolve. This Peer Review Week 2017, COPE (the Committee on Publication Ethics) released a revised, updated version of its guidelines for editors,
Moylan, Elizabeth, Pierson, Charon
core   +2 more sources

Solving the riddle by puzzling it out: overcoming the challenges of harm–benefit analysis by assembling a compound model and practice-oriented tool

Frontiers in Veterinary Science
The practical application of harm–benefit analysis (HBA), a requirement mandated by European Union Directive 2010/63/EU, has been extensively examined. However, reviewing bodies can access only sparse and often incomplete HBA guidance.
Dominik Hajosi, Dominik Hajosi, Herwig Grimm   +2 more
doaj   +1 more source

Ethical review procedures in international internet-based intervention studies. [PDF]

Internet Interv, 2022
Looijmans A, Spahrkäs SS, Sanderman R, Hagedoorn M.   +3 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Intellectual Property Protection of New Animal Breeds in China: Theoretical Justification, International Comparison, and Institutional Construction

Animals
As vital outcomes of agricultural technological innovation, new animal breeds are not only foundational to rural revitalization but also central to preserving ecological diversity.
Wenfei Zhang, Xinyi Chen
doaj   +1 more source