Results 131 to 140 of about 12,286,533 (342)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Ethical Leadership: Conceptualization and Measurement

, 2017
The construct of ethical leadership has garnered much research attention in recent years. However, researchers have not reached consensus on the conceptualization and measurement of ethical leadership.
Sun, Jianmin, Lu, X
core  

The contribution of ethical concepts to the development of professional applied psychology [PDF]

, 2009
In this PhD by publication, the author’s work concerning what it is to be a psychologist operating - sometimes simultaneously - within different ethical domains will be examined using conference papers, journal publications and book chapters.
Kwiatkowski, Richard
core  

Ethical Review Challenges and Practices of Brain-Computer Interfaces Research in Psychiatry

Yixue yu zhexue
In psychiatric research involving brain-computer interface (BCI) technologies, most participants are individuals with severe, treatment-resistant conditions, whose urgent desire for relief may compromise their decision-making capacity.
Li LI, Lingling YE, Weimin YANG
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Review: Thomas Albrecht, The Ethical Vision of George Eliot

, 2020
Article from the George Eliot Review, digitized and hosted by the George Eliot Review Online ...
Brooks-Ward, Issy
core   +1 more source

Solving the riddle by puzzling it out: overcoming the challenges of harm–benefit analysis by assembling a compound model and practice-oriented tool

Frontiers in Veterinary Science
The practical application of harm–benefit analysis (HBA), a requirement mandated by European Union Directive 2010/63/EU, has been extensively examined. However, reviewing bodies can access only sparse and often incomplete HBA guidance.
Dominik Hajosi, Dominik Hajosi, Herwig Grimm   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Intellectual Property Protection of New Animal Breeds in China: Theoretical Justification, International Comparison, and Institutional Construction

Animals
As vital outcomes of agricultural technological innovation, new animal breeds are not only foundational to rural revitalization but also central to preserving ecological diversity.
Wenfei Zhang, Xinyi Chen
doaj   +1 more source

A narrative review on the development of the ethical review mode of multicenter clinical trials in China. [PDF]

Ann Transl Med, 2022
Ding J, Yin Y, Fang K, Zhang W, Luo S.
europepmc   +1 more source