Results 81 to 90 of about 1,339,863 (299)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Identification of neuropathogenic Varicellovirus equidalpha1 as a potential cause of respiratory disease outbreaks among horses in North Xinjiang, China, from 2021-2023

BMC Veterinary Research
Background Varicellovirus equidalpha1 (formerly Equid alphaherpesvirus 1, EqAHV-1) is among the most important viruses responsible for respiratory disease outbreaks among horses throughout the world.
Panpan Tong, Enhui Yang, Bin Liu, Shuyao tian, Youtu Suo, JuanJuan Pan, Yueyi Dang, Nuerlan Palidan, Chenyang Jia, Ling Kuang, Jinxin Xie   +10 more
doaj   +1 more source

Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study

Frontiers in Oral Health
AimTo investigate the effect of periodontal therapy on endothelial function of subjects with periodontitis in stages III or IV and established cardiovascular disease.Materials and methodsA triple-blinded, parallel groups, randomized clinical trial of 6 ...
Ana Molina, Nagore Ambrosio, María Molina, Eduardo Montero, Leire Virto, David Herrera, Elena Figuero, Mariano Sanz   +7 more
doaj   +1 more source

Mortality Trends of Stomach Cancer in Qidong City, 1972—2016

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate the mortality trends of stomach cancer from 1972 to 2016 in Qidong, Jiangsu Province. Methods We collected and analyzed the mortality of stomach cancer in Qidong from 1972 to 2016 by gender and age from the cancer registry data ...
DING Lulu, ZHU Jian, ZHANG Yonghui, CHEN Yongsheng, WANG Jun, CHEN Jianguo   +5 more
doaj   +1 more source

Disc disease: A summary and review [PDF]

, 1993
A review of the etiology, clinical, radiological and laboratory presentation, differential diagnosis and management goals of disc disease is presented.
Walker, B.F.
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Etiology of Severe Non-malaria Febrile Illness in Northern Tanzania: A Prospective Cohort Study. [PDF]

, 2013
The syndrome of fever is a commonly presenting complaint among persons seeking healthcare in low-resource areas, yet the public health community has not approached fever in a comprehensive manner.
AJ Bouley, Anne B. Morrissey, B Nadjm, B Nadjm, B Pastorino, BM Greenwood, CA Petti, Charles Muiruri, CIR Chandler, CJ Murray, CJ Murray, DC Clifton, DR Feikin, EA Reddy, Eng Eong Ooi, Grace D. Kinabo, H Reyburn, HM Biggs, JA Berkley, JA Crump, JA Crump, JA Crump, JA Crump, John A. Bartlett, John A. Crump, JT Hertz, K Baltzell, LE Scott, LK Archibald, M Amexo, M Prabhu, Mathieu Picardeau, MD Bajani, MK Mayhood, MM Levine, N Scaramozzino, OS Levine, PA Connolly, PL Petit, R Lozano, Renee L. Galloway, Robert F. Massung, Robyn A. Stoddard, SI Hay, SJ Olsen, SL Brown, SM Graham, SM Lofgren, TJ O'Dempsey, Venance P. Maro, Wilbrod Saganda, William L. Nicholson, YL Lai   +52 more
core   +6 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

SLC transporters as metalloptotic gatekeepers in tumorigenesis: From molecular mechanisms to clinical potential

Pharmacological Research
Solute carrier (SLC) transporters exert a crucial effect on metalloptosis in tumors via governing the translocation of ions and amino acids across cellular and organelle membranes.
Bingchen Pan, Tan Li, Na Deng, Xin Zhang, Yangjie Peng, Yanke Li, Jingjing Jing, Liping Sun   +7 more
doaj   +1 more source

Antimicrobial activity of red wine and oenological extracts against periodontal pathogens in a validated oral biofilm model

BMC Complementary and Alternative Medicine, 2019
Background Previous research findings support an antimicrobial effect of polyphenols against a variety of pathogens, but there is no evidence of this effect against periodontal pathogens in complex biofilms.
María C. Sánchez, Honorato Ribeiro-Vidal, Adelaida Esteban-Fernández, Begoña Bartolomé, Elena Figuero, María V. Moreno-Arribas, Mariano Sanz, David Herrera   +7 more
doaj   +1 more source