Results 51 to 60 of about 15,180 (187)

Consensus on the Management of Anesthetic Agents During Digestive Motility Measurements and Proposal of a Standardized Protocol for Anesthesia (French Neuro Gastroenterology Group GFNG and Committee of Anesthetic French Experts)

Neurogastroenterology &Motility, EarlyView.
Anesthesia can alter measurements during digestive endoscopies, yet no standardized protocol currently exists. Two expert groups—the French Neuro‐Gastroenterology Group (GFNG) and anesthesiologists—used the Delphi method to reach a consensus on which drugs have an influence (91 amendments), ultimately resulting in a proposed anesthesia protocol (28 ...
Domitille Renard, Thomas Clavier, Osama Abou‐Arab, Gérard Amarenco, Emmanuel Besnier, Alice Blet, Matthieu Boisson, Charlène Brochard, Benoit Coffin, Audrey De Jong, Denis Frasca, Marc Garnier, Aurelie Gouel, Jérémie Jacques, Arthur James, Yoann Launey, Anne‐Marie Leroi, Chloé Melchior, Daphné Michelet, François Mion, Maxime Nguyen, Emmanuel Rineau, Amélie Rollé, Sabine Roman, Stéphanie Sigaut, Heithem Soliman, Fabien Wuestenberghs, Frank Zerbib, Guillaume Gourcerol, Charlotte Desprez   +29 more
wiley   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors [PDF]

, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav, Bracamontes, John R, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F, Evers, Alex S, Germann, Allison L, Kathiresan, Krishnan, Manion, Brad, Qian, Ming-Xing, Reichert, David E, Shin, Daniel J   +12 more
core   +3 more sources

Emerging methods for subtype differentiation in primary aldosteronism

Journal of Internal Medicine, Volume 299, Issue 2, Page 178-195, February 2026.
Abstract Primary aldosteronism (PA) is a common cause of hypertension. Compared to patients with essential hypertension, untreated PA is associated with a two‐ to fourfold greater risk of cardiovascular disease, renal failure, and death. PA is caused by increased secretion of aldosterone from one adrenal gland in 30% of the patients and both adrenal ...
Oskar Ragnarsson, C. Christofer Juhlin, Tobias Åkerström, Per Dahlqvist, Henrik Falhammar, Per Hellman   +5 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Selective inhibition of extra-synaptic α5-GABA_A receptors by S44819, a new therapeutic agent [PDF]

, 2017
In the mammalian central nervous system (CNS) GABAA receptors (GABAARs) mediate neuronal inhibition and are important therapeutic targets. GABAARs are composed of 5 subunits, drawn from 19 proteins, underpinning expression of 20-30 GABAAR subtypes.
Adam R. Brown, Adrienn Pálvölgyi, Atack, Balázs Mihalik, Barker, Belelli, Ben G. Gunn, Bergmann, Bolognani, Bonin, Botta, Brown, Brown, Brown, Capogna, Caraiscos, Clarkson, Cobb, Darmani, Delia Belelli, Drexel, Ferenc A. Antoni, Fisahn, Fritschy, Gacsályi, Gacsályi, Hausrat, Herd, Herd, Huerta, István Gacsályi, István Ling, Jeremy J. Lambert, Jones, József Barkóczy, Karayannis, Katalin Pallagi, Keene, Kinnavane, Knust, Lake, Lerma, Ling, Ling, Lori-An Etherington, Lüddens, Maconochie, Martin, Matthew R. Livesey, Mendez, Michael Spedding, Mihalik, Milic, Neves, Olivia Monteiro, Olsen, Peden, Pirker, Prenosil, Péter Varga, Redrobe, Rudolph, Salesse, Salmon, Serwanski, Szabolcs Kertész, Thompson, Ueno, Wang, Wisden, Wlodarczyk, Wu, Zarnowska, Zhang, Zurek   +74 more
core   +2 more sources

Exception from Informed Consent and Waiver of Informed Consent for Comparative Effectiveness Trials in Emergency Care Research

Ethics &Human Research, Volume 48, Issue 1, Page 31-41, January–February 2026.
ABSTRACT For many of the decisions made in the clinical care setting, clinicians lack evidence to inform which treatment would result in the best patient outcomes. This problem is particularly common in emergency care, a field in which the condition of the patient and the urgent nature of the treatment often preclude research conducted using ...
Jonathan D. Casey, Matthew W. Semler, Jeremy Brown, Clifton W. Callaway, Stephanie C. DeMasi, Neal W. Dickert, Luke Gelinas, Francis X. Guyette, Ann R. Johnson, Wesley H. Self, Todd W. Rice, Stephanie R. Morain   +11 more
wiley   +1 more source

Comparing the Effect of Sodium Thiopental, Magnesium Sulfate, Midazolam, Prime Etomidate, and Remifentanil on Myoclonus Incidence and Pain Induced by Anesthesia with Etomidate

مجله دانشکده پزشکی اصفهان, 2018
Background: This study aimed to compare premedication with sodium thiopental, magnesium sulfate, midazolam, prime etomidate dosage, remifentanil, and normal saline on decreasing myoclonus incidence and pain induced by anesthesia with etomidate. Methods:
Mohammadreza Safavi, Azim Honarmand, Shahrbanoo Zolfaghari   +2 more
doaj   +1 more source

Perioperative management of septic peritonitis in small animals: A review

Veterinary Surgery, Volume 55, Issue 1, Page 39-58, January 2026.
Abstract Background Septic peritonitis (SP) is a complex, life‐threatening disease, driven by peritoneal inflammation and microbial contamination, requiring timely and dynamic perioperative management. Aims The aim of this review was to synthesize current knowledge on the perioperative management of SP in dogs and cats.
Shana K. O'Marra, Bonnie G. Campbell
wiley   +1 more source

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. [PDF]

, 2019
Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity-a phenomenon known as paradoxical excitation.
Bruni, Giancarlo, Carbajal, Amanda, Gendelev, Leo, Gong, Jung Ho, Helsell, Cole, Kang, Hye Jin, Keiser, Michael J, Kinser, Reid, Kokel, David, McCarroll, Matthew N, Myers-Turnbull, Douglas, Peterson, Randall T, Rinaldi, Capria, Sello, Jason K, Taylor, Jack, Tomita, Susumu   +15 more
core   +1 more source

The Efficacy of Clove Seed Aqueous Extract as an Anesthetic Agent on the Stress Response of Mystus cavasius During Transportation

Aquaculture Research, Volume 2026, Issue 1, 2026.
Mystus cavasius (locally known as Gulsha) is a commercially important catfish in Bangladesh, typically transported live in oxygenated polythene bags without anesthetics, often resulting in severe stress, injuries, and high mortality. This study evaluated the efficacy of clove seed aqueous extract (CAE) as a natural anesthetic at different ...
Nafisa Khatun, Nusrat Jahan Sumaiya, Nishat Sultana, Shajjad Hossian, Mohammad Matiur Rahman   +4 more
wiley   +1 more source