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Expression of matrix metalloproteinase-9 associated with ets-1 proto-oncogene in rat tubulointerstitial cells [PDF]
Nephrology Dialysis Transplantation, 2005 Ets-1 proto-oncogene exhibits multiple activities in the transcriptional regulation of numerous genes including metalloproteinase (MMP)-1, -3 and -9. MMPs play an important role in the remodelling of extracellular matrix in various renal diseases. However, the role of the Ets-1-MMP axis in advanced renal diseases is uncertain.
, Taguchi Takashi
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Renal Expression of the Ets-1 Proto-oncogene during Progression of Rat Crescentic Glomerulonephritis [PDF]
Journal of the American Society of Nephrology: JASN, 2000 The ets-1 proto-oncogene is a member of the transcriptional factor family and was identified by homology to the v-ets oncogene. It was recently demonstrated that Ets-1 protein interacts with the promoter region of the genes coding for proteinases, including matrix metalloproteinase-1 (MMP-1), MMP-3, and urokinase-type plasminogen activator, suggesting ...
Takehiko Koji, , Mohammed S Razzaque
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Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas
Histopathology, 2005Aims : The high incidence of clinically diagnosed prostatic cancer is exceeded by the frequency of tumours detected at autopsy. The Ets‐1 proto‐oncogene is expressed by a variety of malignant and normal tissues. Therefore, in this study, expression of Ets‐1 protein was investigated in ‘latent’ prostatic cancer detected at autopsy, compared with benign ...
G, Alipov +7 more
exaly +3 more sources
ETS-1 proto-oncogene as a key newcomer molecule to predict invasiveness in laryngeal carcinoma
Pathology Research and Practice, 2011ETS-1 protein is one of the key regulators in tumor invasion and progression. We aimed to evaluate the role of ETS-1 in the invasiveness and progression of laryngeal squamous carcinoma, as well as to determine the correlations between clinicopathological characteristics and expression of this molecule.
Aysegul Sári, Aysegul Aksoy Altinboga
exaly +4 more sources
Renal expression of proto-oncogene Ets-1 on matrix remodeling in experimental diabetic nephropathy
Acta Histochemica, 2011The molecular mechanisms of glomerulosclerosis and tubulointerstitial fibrosis in diabetic nephropathy (DN) have received scant attention. Ets-1 proto-oncogene plays a role in matrix remodeling by regulating matrix-degrading enzymes. We investigated the possible role of Ets-1 in the pathogenesis of DN.
Xiao-Min Liu
exaly +3 more sources
The c-ets-1 proto-oncogenes in Xenopus laevis: expression during oogenesis and embryogenesis
Mechanisms of Development, 1993We previously reported the cloning and sequencing of two cDNAs derived from the Xenopus laevis ets-1 gene (Stiegler et al., 1990). The Xl-ets-1a cDNA encodes a polypeptide highly homologous to known ets-1 proteins. The 3'-UTR contains two AATAAA polyadenylation signals together with three copies of the TTTTTAT sequence thought to confer a maturation ...
P, Stiegler +7 more
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The Journal of Immunology, 1991
Abstract Recent studies have demonstrated that the nuclear protein, Ets-1, which is preferentially expressed in lymphocytes, binds to the long terminal repeat of Moloney murine sarcoma virus and HTLV-1 and regulates gene expression. The association of Ets-1 with DNA has been shown to be lost when the protein is phosphorylated.
C L, Fisher, J, Ghysdael, J C, Cambier
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Abstract Recent studies have demonstrated that the nuclear protein, Ets-1, which is preferentially expressed in lymphocytes, binds to the long terminal repeat of Moloney murine sarcoma virus and HTLV-1 and regulates gene expression. The association of Ets-1 with DNA has been shown to be lost when the protein is phosphorylated.
C L, Fisher, J, Ghysdael, J C, Cambier
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Polymorphism of the proto-oncogene ETS-1 in hematological malignancies.
Leukemia, 1990We studied a novel restriction fragment length polymorphism (RFLP) of the proto-oncogenes ETS-1 that we detected in a patient with an acute monocytic leukemia by the presence of two, 3.7 and 10 kb, Xbal fragments on Southern blots of DNA from blast cells and remission blood samples. RFLP analysis of a series of 114 normal donors revealed that only four
J P, Kerckaert +9 more
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The International Journal of Developmental Biology, 1993
Many of the Ets proteins have been shown to be transcription activators. In vitro, Ets 1 proteins are involved in the transcriptional induction of genes such as stromelysin 1, collagenase 1 or urokinase type plasminogen activator, which are proteases responsible for extracellular matrix degradation.
D, Grevin +5 more
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Many of the Ets proteins have been shown to be transcription activators. In vitro, Ets 1 proteins are involved in the transcriptional induction of genes such as stromelysin 1, collagenase 1 or urokinase type plasminogen activator, which are proteases responsible for extracellular matrix degradation.
D, Grevin +5 more
openaire +2 more sources
Expression of the ets-1 proto-oncogene in human pancreatic carcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1998The proto-oncogene, ets-1, is a transcription factor that controls the expression of a number of genes involved in extracellular matrix remodeling. It might play a role in cell migration and tumor invasion. To elucidate the involvement of Ets-1 in human pancreatic carcinoma, we performed immunohistochemical analysis on tissue from 10 normal pancreases ...
T, Ito +5 more
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