Results 31 to 40 of about 5,276 (141)

EUCAST Technical Note on tigecycline

, 2006
Tigecycline is an injectable antibacterial agent derived from the tetracyclines and classified by the manufacturer as a glycylcycline. Tigecycline was registered by the European Medicines Agency (EMEA) in May 2006 for parenteral use in complicated ...
HRYNIEWICZ W., VARALDO, Pietro, RODLOFF A., CANTON R., MACGOWAN A. P., BROWN D. F. J., GOLDSTEIN F., MOUTON J. W., STEINBAKK M., KAHLMETER G., ODENHOLT I.   +10 more
core   +1 more source

Time to switch from CLSI to EUCAST? A Southeast Asian perspective. [PDF]

, 2019
Despite the importance of antimicrobial susceptibility testing (AST) to clinical management of infection and to antimicrobial resistance (AMR) surveillance, methodologies and breakpoints of the two most commonly used systems worldwide, CLSI and EUCAST ...
Dance, DAB, Turner, Paul, Cusack, TP, Wangrangsimakul, Tri, Roberts, T, Ashley, Elizabeth, Cusack, T-P, Wangrangsimakul, T, Ashley, EA, Ling, CL, Turner, P   +10 more
core   +1 more source

Ceftolozane/Tazobactam Activity Against Drug-Resistant Pseudomonas aeruginosa and Enterobacterales Causing Healthcare-Associated Infections in Eight Asian Countries: Report from an Antimicrobial Surveillance Program (2016–2018)

Infection and Drug Resistance, 2022
Michael Pfaller,1,2 Dee Shortridge,1 Wei-Ting Chen,3 Helio Sader,1 Mariana Castanheira1 1JMI Laboratories, North Liberty, IA, USA; 2University of Iowa College of Medicine, Iowa City, IA, USA; 3Merck & Co., Inc, Kenilworth, NJ, USACorrespondence: Dee ...
Pfaller M, Shortridge D, Chen WT, Sader H, Castanheira M   +4 more
doaj  

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

CLSI – EUCAST: Comparison of antibiotic-susceptibility profile of Enterobacteriaceae of animal origin according to the standards [PDF]

, 2019
Antimicrobial resistance is a relevant “One Health” issue that shows the need of comparison of isolates of different origins. In this way, guidelines for antimicrobial-resistance evaluation in animals are relevant in relation to human sources.
Josman Dantas Palmeira, Palmeira, Josman Dantas, Helena Ferreira, Ferreira, Helena   +3 more
core   +1 more source

EUCAST Ibrexafungerp MICs and Wild-Type Upper Limits for Contemporary Danish Yeast Isolates

Journal of Fungi, 2022
Ibrexafungerp is a novel triterpenoid antifungal that inhibits glucan synthase and thus fungal cell wall synthesis. We examined the in vitro activity against contemporary clinical yeast, investigated inter-laboratory and intra-laboratory variability ...
Karin M. Jørgensen, Karen M. T. Astvad, Rasmus K. Hare, Maiken C. Arendrup   +3 more
doaj   +1 more source

Relationship between continuous infusion meropenem PK/PD target attainment and C‐reactive protein dynamics in onco‐haematologic patients with febrile neutropenia

British Journal of Clinical Pharmacology, EarlyView.
Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu, Pier Giorgio Cojutti, J. G. Coen van Hasselt, Michele Bartoletti, Maddalena Giannella, Pierluigi Zinzani, Pierluigi Viale, Federico Pea   +7 more
wiley   +1 more source

MIC of amoxicillin/clavulanate according to CLSI and EUCAST: Discrepancies and clinical impact in patients with bloodstream infections due to Enterobacteriaceae

, 2017
Objectives: To compare results of amoxicillin/clavulanate susceptibility testing using CLSI and EUCAST methodologies and to evaluate their impact on outcome in patients with bacteraemia caused by Enterobacteriaceae.
Borrell, Nuria, Valiente-Mendez, Adoración, Causse, Manuel, Almela, Manel, Corzo, J. Enrique [0000-0001-9687-4009], Lepe, Jose Antonio [0000-0002-3635-4930], Peña, Carmen, Martínez-Martínez, Luis [0000-0002-6091-4045], Shan, Adriana, Cisneros, José Miguel [0000-0001-5001-672X], Galán, María Elvira, García-Álvarez, Lara [0000-0002-6518-9698], Delgado-Valverde, Mercedes [0000-0002-2961-2620], Gurgui, Mercedes, de Alegría, Carlos Ruíz, Bou, Germán [0000-0001-8837-0062], Torres, Eva, Gutiérrez-Gutiérrez, Belén [0000-0002-9668-0770], Torre-Cisneros, Julián [0000-0002-5095-2398], Sanz, Mercedes, Cueto, Marina de, Prim, Núria, Cantón, Rafael, Planes-Reig, Ana María, Rodríguez-Baño, Jesús [0000-0001-6732-9001], Tubau-Quintano, Fe [0000-0002-6416-6451], Almirante, Benito, Morosini, M. Isabel, Pascual, Álvaro [0000-0002-8672-5891], Gómez-Zorrilla, Silvia, Gracia-Ahufinger, Irene [0000-0001-7714-6620], Guzmán-Puche, Julia, Aller-García, Ana Isabel   +32 more
core   +1 more source

Population-based inference of aminoglycoside resistance mechanisms in Escherichia coliResearch in context

EBioMedicine, 2019
Background: Interpretative reading of antimicrobial susceptibility test (AST) results allows inferring biochemical resistance mechanisms from resistance phenotypes.
Stefano Mancini, Martina Marchesi, Frank Imkamp, Karoline Wagner, Peter M. Keller, Chantal Quiblier, Elias Bodendoerfer, Patrice Courvalin, Erik C. Böttger   +8 more
doaj   +1 more source